Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study.: single-item of depression and mortality

Thomas Lefèvre 1, 2 Archana Singh-Manoux 2, 3, 4 Silvia Stringhini 2 Aline Dugravot 2 Cédric Lemogne 5, 6, 7 Silla Consoli 5, 6 Marcel Goldberg 2 Marie Zins 2 Hermann Nabi 2, *
* Auteur correspondant
1 LaTIM - Laboratoire de Traitement de l'Information Medicale
2 CESP - Centre de recherche en épidémiologie et santé des populations
3 Department of Epidemiology and Public Health
4 Centre de Gérontologie
5 UPD5 - Université Paris Descartes - Paris 5
6 Service Universitaire de Psychiatrie de l'Adulte et du sujet âgé
7 Centre Emotion
Abstract : BACKGROUND: It remains unknown whether short measures of depression perform as well as long measures in predicting adverse outcomes such as mortality. The present study aims to examine the predictive value of a single-item measure of depression for mortality. METHODS: A total of 14,185 participants of the GAZEL cohort completed the 20-item Center-for-Epidemiologic-Studies-Depression (CES-D) scale in 1996. One of these items (I felt depressed) was used as a single-item measure of depression. All-cause mortality data were available until 30 September 2009, a mean follow-up period of 12.7 years with a total of 650 deaths. RESULTS: In Cox regression model adjusted for baseline socio-demographic characteristics, a one-unit increase in the single-item score (range 0-3) was associated with a 25% higher risk of all-cause mortality (95% CI: 13-37%, P<0.001). Further adjustment for health-related behaviours and physical chronic diseases reduced this risk by 36% and 8%, respectively. After adjustment for all these variables, every one-unit increase in the single-item score predicted a 15% increased risk of death (95% CI: 5-27%, P<0.01). There is also an evidence of a dose-reponse relationship between reponse scores on the single-item measure of depression and mortality. CONCLUSION: This study shows that a single-item measure of depression is associated with an increased risk of death. Given its simplicity and ease of administration, a very simple single-item measure of depression might be useful for identifying middle-aged adults at risk for elevated depressive symptoms in large epidemiological studies and clinical settings.
Keywords : depression single-item mortality
Type de document :
Article dans une revue
European Journal of Public Health, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2012, 22 (5), pp.643-7. 〈10.1093/eurpub/ckr103〉
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http://www.hal.inserm.fr/inserm-00816922
Contributeur : Annie Schmaus <>
Soumis le : mardi 23 avril 2013 - 11:39:46
Dernière modification le : jeudi 20 septembre 2018 - 15:03:32
Document(s) archivé(s) le : jeudi 25 juillet 2013 - 11:23:04

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Thomas Lefèvre, Archana Singh-Manoux, Silvia Stringhini, Aline Dugravot, Cédric Lemogne, et al.. Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study.: single-item of depression and mortality. European Journal of Public Health, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2012, 22 (5), pp.643-7. 〈10.1093/eurpub/ckr103〉. 〈inserm-00816922〉

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