J. Abel and T. Haarmann-stemmann, An introduction to the molecular basics of aryl 318 hydrocarbon receptor biology, Biological chemistry, vol.391, pp.1235-1283, 2010.

R. Barouki, X. Coumoul, and P. M. Fernandez-salguero, The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein, FEBS Letters, vol.21, issue.182, pp.3608-3623, 2007.
DOI : 10.1016/j.febslet.2007.03.046

M. Benahmed, [Role of tumor necrosis factor in the male gonad]. Contraception, 322 fertilite, sexualite, pp.569-71, 1992.

B. Bilinska, C. Genissel, and S. Carreau, Paracrine effect of seminiferous tubule 324 factors on rat Leydig cell testosterone production: role of cytoskeleton, under the auspices of the European Cell Biology Organization, pp.435-477, 1997.

P. C. Boutros, K. A. Bielefeld, R. Pohjanvirta, and P. A. Harper, Dioxin-dependent 327 and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice, Toxicol Sci, vol.112, pp.328-245, 2009.

M. M. Garcia, A. B. Acquier, M. Cooke, C. F. Mendez, E. J. Podesta et al., 334 MAPK phosphatase-1 (MKP-1) expression is up-regulated by hCG/cAMP and modulates 335 steroidogenesis in MA-10 Leydig cells, Endocrinology, vol.152, pp.2665-77, 2011.

J. M. Ward, C. R. Jefcoate, and F. J. Gonzalez, Cytochrome P450 CYP1B1 338 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas, 339 Proceedings of the National Academy of Sciences of the United States of America 96, pp.1977-340, 1999.

S. Carreau, V. Papadopoulos, and M. A. Drosdowsky, Stimulation of Adult Rat Leydig Cell Aromatase Activity by a Sertoli Cell Factor*, Endocrinology, vol.122, issue.3, pp.1103-1112, 1988.
DOI : 10.1210/endo-122-3-1103

C. J. Lee, Y. D. Yoon, Y. H. Yoo, K. , and J. M. , Cellular defense mechanisms 345 against benzo[a]pyrene in testicular Leydig cells: implications of p53, aryl-hydrocarbon 346 receptor, and cytochrome P450 1A1 status, Endocrinology, vol.148, pp.6134-6178, 2007.

O. Ciftci, S. Tanyildizi, and A. Godekmerdan, Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), Immunopharmacology and Immunotoxicology, vol.73, issue.1, pp.99-104, 2010.
DOI : 10.1016/0041-008X(84)90357-0

S. Deb and S. M. Bandiera, Regulation of Cytochrome P450 1B1 Expression by 351 Luteinizing Hormone in Mouse MA-10 and Rat R2C Leydig Cells: Role of Protein Kinase A. 352 Biology of reproduction, p.353, 2011.

S. Deb, M. Kawai, T. K. Chang, and S. M. Bandiera, CYP1B1 expression in rat 354 testis and Leydig cells is not inducible by aryl hydrocarbon receptor agonists. Xenobiotica; 355 the fate of foreign compounds in biological systems, pp.447-57, 2010.

E. Diamanti-kandarakis, J. P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins et al., Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement, Endocrine Reviews, vol.30, issue.4, pp.293-342, 2009.
DOI : 10.1210/er.2009-0002

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726844

R. S. Ge, Q. Dong, C. M. Sottas, H. Chen, B. R. Zirkin et al., Gene Expression in Rat Leydig Cells During Development from the Progenitor to Adult Stage: A Cluster Analysis1, Biology of Reproduction, vol.72, issue.6, pp.1405-1420, 2005.
DOI : 10.1095/biolreprod.104.037499

D. T. Graves and Y. Jiang, Chemokines, a Family of Chemotactic Cytokines, Critical Reviews in Oral Biology & Medicine, vol.6, issue.2, pp.109-127, 1995.
DOI : 10.1177/10454411950060020101

V. A. Guazzone, P. Jacobo, M. S. Theas, and L. Lustig, Cytokines and chemokines 365 in testicular inflammation: A brief review, Microscopy research and technique 72, pp.620-628, 2009.

T. Haarmann-stemmann, H. Bothe, A. , and J. , Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways, Biochemical Pharmacology, vol.77, issue.4, pp.508-528, 0368.
DOI : 10.1016/j.bcp.2008.09.013

C. Y. Hong, J. H. Park, R. S. Ahn, S. Y. Im, H. S. Choi et al., Molecular mechanism of suppression of testicular steroidogenesis by 371 proinflammatory cytokine tumor necrosis factor alpha, Molecular and cellular biology, vol.370, issue.372, pp.2593-604, 2004.

P. M. Foster, C. L. Gray, and L. E. Gray, Fifteen years after "Wingspread"-- 375 environmental endocrine disrupters and human and wildlife health: where we are today and 376 where we need to go, Toxicol Sci, vol.105, pp.235-59, 2008.

O. Hankinson, A proposed mechanism for the protective effect of dioxin against 379 breast cancer, Toxicol Sci, vol.98, pp.436-480, 2007.

A. V. Huber, L. Saleh, J. Prast, P. Haslinger, and M. Knofler, Human chorionic gonadotrophin attenuates NF-??B activation and cytokine expression of endometriotic stromal cells, Molecular Human Reproduction, vol.13, issue.8, pp.595-604, 2007.
DOI : 10.1093/molehr/gam032

L. Johnson, C. E. Wilker, S. H. Safe, B. Scott, D. D. Dean et al., -Tetrachlorodibenzo-p-dioxin reduces the number, size, and organelle content of 385 Leydig cells in adult rat testes, Toxicology, vol.38437, issue.89, pp.49-65, 1994.
URL : https://hal.archives-ouvertes.fr/jpa-00210025

J. M. Kleeman, R. W. Moore, and R. E. Peterson, Inhibition of testicular 387 steroidogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats: evidence that the key 388 lesion occurs prior to or during pregnenolone formation, pp.112-137, 1990.

M. Korkalainen, J. Tuomisto, and R. Pohjanvirta, Primary structure and inducibility 391 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a 392 TCDD-sensitive and a TCDD-resistant rat strain, Biochemical and biophysical research 393 communications 315, pp.123-154, 2004.

K. P. Lai, M. H. Wong, and C. K. Wong, Inhibition of CYP450scc expression in dioxin-exposed rat Leydig cells, Journal of Endocrinology, vol.185, issue.3, pp.519-546, 2005.
DOI : 10.1677/joe.1.06054

G. S. Leung, M. Kawai, J. K. Tai, J. Chen, S. M. Bandiera et al., 397 Developmental expression and endocrine regulation of CYP1B1 in rat testis. Drug 398 metabolism and disposition: the biological fate of chemicals, pp.523-531, 2009.

C. Lundqvist, M. Zuurbier, M. Leijs, C. Johansson, S. Ceccatelli et al., The effects of PCBs and dioxins on child 401 health, Acta Paediatr, pp.55-64, 2006.

. Dimethylbenz, anthracene inhibition of steroid production in MA-10 mouse Leydig tumor 404 cells is not directly linked to induction of CYP1B1, Toxicology and applied pharmacology, vol.405, pp.175-200

M. Guittot, S. Verot, A. Odet, F. Chauvin, M. A. Le-magueresse-battistoni et al., A comprehensive survey of the laminins and collagens type IV expressed in mouse 408, 2008.

A. S. Midzak, H. Chen, V. Papadopoulos, and B. R. Zirkin, Leydig cell aging and the mechanisms of reduced testosterone synthesis, Molecular and Cellular Endocrinology, vol.299, issue.1, pp.23-31, 2009.
DOI : 10.1016/j.mce.2008.07.016

J. Mimura, M. Ema, K. Sogawa, and Y. Fujii-kuriyama, Identification of a novel mechanism of regulation of Ah (dioxin) receptor function, Genes & Development, vol.13, issue.1, pp.20-25, 1999.
DOI : 10.1101/gad.13.1.20

J. Mimura and Y. Fujii-kuriyama, Functional role of AhR in the expression of toxic effects by TCDD, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1619, issue.3, pp.263-271, 2003.
DOI : 10.1016/S0304-4165(02)00485-3

M. Diaye, L. Ferrec, and E. , 8-tetrachlorodibenzo-p-dioxin. 419 Toxicology and applied pharmacology 79, Androgenic deficiency in male rats treated with 2, pp.99-111

P. Monteiro, C. Rauch, M. D. Galibert, and O. Fardel, Aryl hydrocarbon receptor- 422 and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant 423 benzo, pp.19906-19921, 2006.

S. Nishiumi, M. Yoshida, T. Azuma, K. Yoshida, and H. Ashida, 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Impairs an Insulin Signaling Pathway through the Induction of Tumor Necrosis Factor-?? in Adipocytes, Toxicological Sciences, vol.115, issue.2, pp.482-91, 2008.
DOI : 10.1093/toxsci/kfq052

H. Nomiyama, N. Osada, Y. , and O. , The evolution of mammalian chemokine genes, Cytokine & Growth Factor Reviews, vol.21, issue.4, pp.253-62, 2010.
DOI : 10.1016/j.cytogfr.2010.03.004

H. Dechaud, S. Magre, L. Magueresse-battistoni, and B. , The effects of an in utero 431 exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification 432 of Ccl5 as a potential marker, International journal of andrology, vol.33, pp.413-437, 2010.

M. Huikko, Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor 435 nuclear translocator messenger ribonucleic acids and proteins in rat and human testis, 436 Endocrinology, vol.144, pp.767-76, 2003.

T. Shimada and Y. Fujii-kuriyama, Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1, Cancer Science, vol.12, issue.1, pp.1-6, 2004.
DOI : 10.1126/science.275.5297.218

N. E. Skakkebaek, E. Rajpert-de-meyts, and K. M. Main, Testicular dysgenesis 440 syndrome: an increasingly common developmental disorder with environmental aspects, Human reproduction, vol.441, issue.16, pp.972-980, 2001.
DOI : 10.1111/j.1600-0463.2001.tb05770.x

J. Muller, E. Rajpert-de-meyts, T. Scheike, R. Sharpe, J. Sumpter et al., Male reproductive health and environmental xenoestrogens, Environmental health 446 perspectives 104, pp.741-803, 1996.

C. F. Vogel, N. Nishimura, E. Sciullo, P. Wong, W. Li et al., 448 Modulation of the chemokines KC and MCP-1 by 2, TCDD) in mice. Archives of biochemistry and biophysics 461, pp.8-449, 2007.

J. Yu, Y. Wang, W. H. Zhou, L. Wang, Y. Y. He et al., Combination of 451 estrogen and dioxin is involved in the pathogenesis of endometriosis by promoting chemokine 452 secretion and invasion of endometrial stromal cells, Human reproduction, vol.23, pp.453-1614, 2008.

D. Zhao, E. A. Pritts, V. A. Chao, J. F. Savouret, T. et al., Dioxin 455 stimulates RANTES expression in an in-vitro model of endometriosis, Molecular human 456 reproduction, pp.849-54, 2002.