 |
Journal articles
Role of a short tandem leucine/arginine repeat in strong mutator phenotype acquisition in a clinical isolate of Salmonella Typhimurium.
Abstract : In this prospective study, a strong mutator strain of Salmonella Typhimurium was isolated from a collection of 130 human clinical strains of Salmonella. Sequence analysis of the mutS, mutL, and mutH genes, which encode three proteins that are essential for initiation of methyl-directed DNA mismatch repair, revealed insertion of a short tandem repeat (STR) of leucine/alanine in the histidine kinase-like ATPase domain of MutL. The role of this STR in the acquisition of the strong mutator phenotype was confirmed by the construction of an isogenic mutant (6bpinsmutL) from a normomutator strain of Salmonella Heidelberg. This result adds to the sparse body of knowledge about strong mutators and highlights the role of this STR as a hotspot for the acquisition of a strong mutator phenotype in Salmonella.
https://www.hal.inserm.fr/inserm-00814119
Contributor : Véronique Touya <>
Submitted on : Tuesday, April 16, 2013 - 3:30:19 PM
Last modification on : Thursday, January 14, 2021 - 11:26:34 AM
Contributor : Véronique Touya <>
Submitted on : Tuesday, April 16, 2013 - 3:30:19 PM
Last modification on : Thursday, January 14, 2021 - 11:26:34 AM
Links full text
