Role of a short tandem leucine/arginine repeat in strong mutator phenotype acquisition in a clinical isolate of Salmonella Typhimurium.

Hervé Le Bars 1 Latifa Bousarghin 1 Martine Bonnaure-Mallet 1 Anne Jolivet-Gougeon 1
1 Microbiologie : Risques Infectieux
Abstract : In this prospective study, a strong mutator strain of Salmonella Typhimurium was isolated from a collection of 130 human clinical strains of Salmonella. Sequence analysis of the mutS, mutL, and mutH genes, which encode three proteins that are essential for initiation of methyl-directed DNA mismatch repair, revealed insertion of a short tandem repeat (STR) of leucine/alanine in the histidine kinase-like ATPase domain of MutL. The role of this STR in the acquisition of the strong mutator phenotype was confirmed by the construction of an isogenic mutant (6bpinsmutL) from a normomutator strain of Salmonella Heidelberg. This result adds to the sparse body of knowledge about strong mutators and highlights the role of this STR as a hotspot for the acquisition of a strong mutator phenotype in Salmonella.
Keywords : short tandem repeat Salmonella mutator mismatch repair mutL short tandem repeat.
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Article dans une revue
FEMS Microbiology Letters, Wiley-Blackwell, 2013, 338 (1), pp.101-6. 〈10.1111/1574-6968.12039〉
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Soumis le : mardi 16 avril 2013 - 15:30:19
Dernière modification le : mercredi 16 mai 2018 - 11:23:28

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BIOSIT | NUMECAN | NUMECAN-CIMIAD | UR1-UFR-SVE | UNIV-RENNES

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Hervé Le Bars, Latifa Bousarghin, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon. Role of a short tandem leucine/arginine repeat in strong mutator phenotype acquisition in a clinical isolate of Salmonella Typhimurium.. FEMS Microbiology Letters, Wiley-Blackwell, 2013, 338 (1), pp.101-6. 〈10.1111/1574-6968.12039〉. 〈inserm-00814119〉

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