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Structural organization of the polysomes adjacent to mammalian processing bodies (P-bodies).

Abstract : A finely tuned balance of translation, storage and decay of mRNAs (mRNAs) is important for the regulation of gene expression. In eukaryotic cells, this takes place in dynamic cytoplasmic RNA-protein granules termed Processing bodies (P-bodies). In this study, by using immunoelectron tomography, 3D modeling and template matching, we analyze the size and the organization of the polysomes in the vicinity of human P-bodies. Our results show the presence of several polysomes that are compatible with a translational activity around P-bodies. Therefore, movement of mRNAs between polysomes and P-bodies can take place when the two compartments are in close contact. The presence of initiation factors in the proximity of P-bodies also suggests that translation of mRNAs can resume at the periphery of these granules.
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https://www.hal.inserm.fr/inserm-00813732
Contributor : Véronique Touya <>
Submitted on : Tuesday, April 16, 2013 - 10:52:26 AM
Last modification on : Thursday, June 4, 2020 - 12:32:07 AM

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Nicolas Cougot, Anne-Elisabeth Molza, Emmanuel Giudice, Annie Cavalier, Daniel Thomas, et al.. Structural organization of the polysomes adjacent to mammalian processing bodies (P-bodies).. RNA Biology, Taylor & Francis, 2013, 10 (2), pp.314-20. ⟨10.4161/rna.23342⟩. ⟨inserm-00813732⟩

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