Social stress models in depression research: what do they tell us? - Archive ouverte HAL Access content directly
Journal Articles Cell and Tissue Research Year : 2013

Social stress models in depression research: what do they tell us?

(1)
1

Abstract

Interest has recently surged in the use of social stress models, especially social defeat. Such interest lies both in the recognition that stressors of social origin play a major role in human psychopathologies and in the acknowledgement that natural and hence ethologically-based stress models have important translational value. The use of the most recent technology has allowed the recognition of the mechanisms through which social defeat might have enduring psychoneuroendocrine effects, especially social avoidance and anhedonia, two behaviours relevant to human depression. In view of the sensitivity of these behavioural outcomes to repeated antidepressant treatments, the social defeat model has been proposed as a possible animal model of depression. The present survey is aimed at examining the limits of such an interpretation and focuses on methodological aspects and on the relevance of social defeat to the study of anxiety-related pathologies.
Fichier principal
Vignette du fichier
Review_Chaouloff_CTR_13_0012_REVISED.pdf (224.06 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

inserm-00813556 , version 1 (15-04-2014)

Identifiers

Cite

Francis Chaouloff. Social stress models in depression research: what do they tell us?. Cell and Tissue Research, 2013, epub ahead of print. ⟨10.1007/s00441-013-1606-x⟩. ⟨inserm-00813556⟩

Collections

INSERM
134 View
285 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More