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Outcome of patients with advanced solitary fibrous tumors: the Centre Léon Bérard experience.

Abstract : BACKGROUND: Solitary Fibrous Tumor is a rare type of soft tissue tumor of intermediate malignant potential which may recur or metastasize in 15-20% of cases. Data on the management of patients with advanced SFT is scarce: chemotherapy has been described as ineffective, while recent data suggests that anti-angiogenic therapies may be more efficient. METHODS: We conducted a retrospective study on patients treated for advanced SFT at a single institution: from January 1994 to December 2011, 30 patients were treated in the Centre Léon Bérard for an advanced SFT. RESULTS: Twenty-three patients received cytotoxic chemotherapy as first-line therapy. Best responses were 2 (9%) partial responses, 13 (57%) stable diseases (SD) and 8 (35%) progressive diseases (PD). Median Progression Free Survival (PFS) was 5.2 (95% CI: 3.2-7.1) months and 9 patients were free of progression at 6 months. Ten patients received an anti-angiogenic treatment (sunitinib or pazopanib) as a 2nd, 3rd or 4th line. Best responses were 5 SD and 5 PD; median PFS was 5.1 months (95% CI 0.7-9.6). Four patients (36%) were progression-free for more than 6 months. Two patients receiving pazopanib were without progression at 6 and 8 months and two patients receiving sunitinib were free of progression at 30 months. CONCLUSION: Response rate with standard chemotherapy was low and PFS appear similar between cytotoxic chemotherapy and anti-angiogenic agents.
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Submitted on : Thursday, April 11, 2013 - 1:03:13 PM
Last modification on : Monday, October 13, 2014 - 3:43:25 PM
Long-term archiving on: : Friday, July 12, 2013 - 4:06:30 AM

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Alice Levard, Olfa Derbel, Pierre Méeus, Dominique Ranchère, Isabelle Ray-Coquard, et al.. Outcome of patients with advanced solitary fibrous tumors: the Centre Léon Bérard experience.. BMC Cancer, BioMed Central, 2013, 13 (1), pp.109. ⟨10.1186/1471-2407-13-109⟩. ⟨inserm-00811931⟩

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