A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity, Science, vol.316, issue.5826, pp.889-894, 2007. ,
DOI : 10.1126/science.1141634
Variation in FTO contributes to childhood obesity and severe adult obesity, Nature Genetics, vol.165, issue.6, pp.724-726, 2007. ,
DOI : 10.1073/pnas.0400782101
URL : https://hal.archives-ouvertes.fr/hal-00173651
Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related Traits, PLoS Genetics, vol.16, issue.7, p.115, 2007. ,
DOI : 10.1371/journal.pgen.0030115.st005
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis, The Journal of Lipid Research, vol.49, issue.3, pp.607-611, 2008. ,
DOI : 10.1194/jlr.M700448-JLR200
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans, Diabetologia, vol.39, issue.4, pp.641-647, 2008. ,
DOI : 10.1007/s00125-008-0928-9
Regulation of Fto/Ftm gene expression in mice and humans, AJP: Regulatory, Integrative and Comparative Physiology, vol.294, issue.4, pp.1185-1196, 2008. ,
DOI : 10.1152/ajpregu.00839.2007
Inactivation of the Fto gene protects from obesity, Nature, vol.134, issue.7240, pp.894-898, 2009. ,
DOI : 10.1038/nature07848
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene, PLoS Genetics, vol.13, issue.4, p.1000599, 2009. ,
DOI : 10.1371/journal.pgen.1000599.s016
Genes Confer Risk of Type 2 Diabetes Independently of BMI in the German KORA Studies, Hormone and Metabolic Research, vol.40, issue.10, pp.722-726, 2008. ,
DOI : 10.1055/s-2008-1078730
FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians, Diabetologia, vol.51, issue.2, pp.247-252, 2009. ,
DOI : 10.1007/s00125-008-1186-6
Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians, pp.2226-2233, 2008. ,
DOI : 10.2337/db07-1583
Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study, Metabolism, vol.58, issue.7, pp.971-975, 2009. ,
DOI : 10.1016/j.metabol.2009.02.019
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTOvariants confer a significant risk, BMC Medical Genetics, vol.40, issue.2, p.59, 2008. ,
DOI : 10.1038/ng.75
Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI, Diabetes, vol.57, issue.5, pp.1419-1426, 2008. ,
DOI : 10.2337/db07-1466
The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain, Endocrinology, vol.149, issue.5, pp.2062-2071, 2008. ,
DOI : 10.1210/en.2007-1457
The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase, Science, vol.318, issue.5855, pp.1469-1472, 2007. ,
DOI : 10.1126/science.1151710
Regulation and Function of FTO mRNA Expression in Human Skeletal Muscle and Subcutaneous Adipose Tissue, Diabetes, vol.58, issue.10, pp.2402-2408, 2009. ,
DOI : 10.2337/db09-0205
Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes, Diabetes, vol.50, issue.5, pp.1134-1142, 2001. ,
DOI : 10.2337/diabetes.50.5.1134
Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle., Journal of Clinical Investigation, vol.98, issue.1, pp.43-49, 1996. ,
DOI : 10.1172/JCI118775
Regulation of gene expression by glucose, Current Opinion in Clinical Nutrition and Metabolic Care, vol.10, issue.4, pp.518-522, 2007. ,
DOI : 10.1097/MCO.0b013e3281298fef
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients, Diabetologia, vol.10, issue.Suppl 2, pp.512-521, 2008. ,
DOI : 10.1007/s00125-007-0913-8
Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells, Diabetologia, vol.47, issue.5, pp.990-999, 2006. ,
DOI : 10.1007/s00125-006-0140-8
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice, Journal of Clinical Investigation, vol.118, pp.789-800, 2008. ,
DOI : 10.1172/JCI32601
URL : https://hal.archives-ouvertes.fr/inserm-00808486
in Insulin-Stimulated Glucose Transport, Molecular Endocrinology, vol.17, issue.12, pp.2448-2460, 2003. ,
DOI : 10.1210/me.2003-0261
Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs, Biochemical Journal, vol.400, issue.1, pp.179-188, 2006. ,
DOI : 10.1042/BJ20060499
URL : https://hal.archives-ouvertes.fr/hal-00478570
Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes, Diabetes, vol.52, issue.6, pp.1319-1325, 2003. ,
DOI : 10.2337/diabetes.52.6.1319
A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, vol.226, pp.497-509, 1957. ,
Microarray background correction: maximum likelihood estimation for the normal-exponential convolution, Biostatistics, vol.10, issue.2, pp.352-363, 2009. ,
DOI : 10.1093/biostatistics/kxn042
Bioconductor: open software development for computational biology and bioinformatics, Genome Biology, vol.5, issue.10, p.80, 2004. ,
DOI : 10.1186/gb-2004-5-10-r80
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments, Statistical Applications in Genetics and Molecular Biology, vol.3, issue.1, p.3, 2004. ,
DOI : 10.2202/1544-6115.1027
Assay of Mitochondrial ATP Synthesis in Animal Cells and Tissues, Methods Cell Biol, vol.80, pp.155-171, 2007. ,
DOI : 10.1016/S0091-679X(06)80007-5
The role of intramuscular lipid in insulin resistance, Acta Physiologica Scandinavica, vol.50, issue.2, pp.373-383, 2003. ,
DOI : 10.1074/jbc.M200958200
The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO-MCBN, the American Diabetes Association and the German Diabetes Society, Diabetes/Metabolism Research and Reviews, vol.26, issue.3, pp.189-212, 2001. ,
DOI : 10.1002/dmrr.196
rs9939609, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.2, pp.596-602, 2009. ,
DOI : 10.1210/jc.2008-1592
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations, The American Journal of Human Genetics, vol.85, issue.1, pp.106-111, 2009. ,
DOI : 10.1016/j.ajhg.2009.06.002
Prevalence of Loss-of-Function FTO Mutations in Lean and Obese Individuals, Diabetes, vol.59, issue.1, pp.311-318, 2010. ,
DOI : 10.2337/db09-0703
Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes, Diabetes, vol.53, issue.6, pp.1412-1417, 2004. ,
DOI : 10.2337/diabetes.53.6.1412
Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha, Int J Obes (Lond), vol.1, pp.5-9, 2005. ,
Non-CpG Methylation of the PGC-1?? Promoter through DNMT3B Controls Mitochondrial Density, Cell Metabolism, vol.10, issue.3, pp.189-198, 2009. ,
DOI : 10.1016/j.cmet.2009.07.011
Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients, Diabetologia, vol.47, issue.5, pp.917-925, 2004. ,
DOI : 10.1007/s00125-004-1394-7
PGC-1??-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes, Nature Genetics, vol.34, issue.3, pp.267-273, 2003. ,
DOI : 10.1038/ng1180
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1, Proceedings of the National Academy of Sciences, vol.100, issue.14, pp.8466-8471, 2003. ,
DOI : 10.1073/pnas.1032913100