N. Bardeesy and R. A. Depinho, Pancreatic cancer biology and genetics, Nature Reviews Cancer, vol.2, issue.12, pp.897-909, 2002.
DOI : 10.1038/nrc949

G. Schneider, J. T. Siveke, F. Eckel, and R. M. Schmid, Pancreatic Cancer: Basic and Clinical Aspects, Gastroenterology, vol.128, issue.6, pp.1606-1625, 2005.
DOI : 10.1053/j.gastro.2005.04.001

E. Maalouf, G. Le-tourneau, C. Batty, G. N. Faivre, S. Raymond et al., Markers involved in resistance to cytotoxics and targeted therapeutics in pancreatic cancer, Cancer Treatment Reviews, vol.35, issue.2, pp.167-174, 2009.
DOI : 10.1016/j.ctrv.2008.10.002

S. P. Kang and M. W. Saif, Pharmacogenomics and pancreatic cancer treatment. Optimizing current therapy and individualizing future therapy, JOP: J. Pancreas, vol.9, pp.251-266, 2008.

R. H. Hruban, A. Maitra, S. E. Kern, and M. Goggins, Precursors to Pancreatic Cancer, Gastroenterology Clinics of North America, vol.36, issue.4, pp.831-849, 2007.
DOI : 10.1016/j.gtc.2007.08.012

R. H. Hruban, R. E. Wilentz, and S. E. Kern, Genetic Progression in the Pancreatic Ducts, The American Journal of Pathology, vol.156, issue.6, pp.1821-1825, 2000.
DOI : 10.1016/S0002-9440(10)65054-7

F. A. Figueiredo, M. Giovannini, G. Monges, S. Charfi, E. Bories et al., Pancreatic Endocrine Tumors, Pancreas, vol.38, issue.8, pp.936-940, 2009.
DOI : 10.1097/MPA.0b013e3181b365db

J. Dekker, J. W. Rossen, H. A. Buller, and A. W. Einerhand, The MUC family: an obituary, Trends in Biochemical Sciences, vol.27, issue.3, pp.126-131, 2002.
DOI : 10.1016/S0968-0004(01)02052-7

J. L. Desseyn, V. Gouyer, and D. Tetaert, Architecture of the gel-forming mucins, The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, pp.1-16, 2008.

S. Yamazoe, H. Tanaka, T. Sawada, R. Amano, N. Yamada et al., RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells, Journal of Experimental & Clinical Cancer Research, vol.29, issue.1, pp.29-53, 2010.
DOI : 10.1186/1756-9966-29-53

N. Jonckheere, Van Seuningen, I. The ever growing family of membrane-bound mucins In The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, pp.17-38, 2008.

N. Jonckheere, The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies, Critical Reviews??? in Oncogenesis, vol.14, issue.2-3, pp.177-196, 2008.
DOI : 10.1615/CritRevOncog.v14.i2-3.30

N. Jonckheere, The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers, Biochimie, vol.92, issue.1, pp.1-11, 2010.
DOI : 10.1016/j.biochi.2009.09.018

M. S. Lan, S. K. Batra, W. N. Qi, R. S. Metzgar, and M. A. Hollingsworth, Cloning and sequencing of a human pancreatic tumor mucin cDNA, J. Biol. Chem, vol.265, pp.15294-15299, 1990.

M. J. Ligtenberg, H. L. Vos, A. M. Gennissen, and J. Hilkens, Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini, J. Biol. Chem, vol.265, pp.5573-5578, 1990.

D. M. Swallow, S. Gendler, B. Griffiths, G. Corney, J. Taylor-papadimitriou et al., The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM, Nature, vol.328, issue.6125, pp.82-84, 1987.
DOI : 10.1038/328082a0

M. A. Hollingsworth and B. J. Swanson, Mucins in cancer: protection and control of the cell surface, Nature Reviews Cancer, vol.4, issue.1, pp.45-60, 2004.
DOI : 10.1038/nrc1251

D. Meerzaman, P. S. Shapiro, and K. C. Kim, Involvement of the MAP kinase ERK2 in MUC1 mucin signaling, Am. J. Physiol. Lung Cell Mol. Physiol, vol.281, pp.86-91, 2001.

J. J. Ho and Y. S. Kim, Serological Pancreatic Tumor Markers and the MUC1 Apomucin, Pancreas, vol.9, issue.6, pp.674-691, 1994.
DOI : 10.1097/00006676-199411000-00002

J. A. Schroeder, M. C. Adriance, M. C. Thompson, T. D. Camenisch, and S. J. Gendler, MUC1 alters ??-catenin-dependent tumor formation and promotes cellular invasion, Oncogene, vol.22, issue.9, pp.1324-1332, 2003.
DOI : 10.1038/sj.onc.1206291

H. Tsutsumida, B. J. Swanson, P. K. Singh, T. C. Caffrey, S. Kitajima et al., RNA Interference Suppression of MUC1 Reduces the Growth Rate and Metastatic Phenotype of Human Pancreatic Cancer Cells, Clinical Cancer Research, vol.12, issue.10, pp.2976-2987, 2006.
DOI : 10.1158/1078-0432.CCR-05-1197

N. Moniaux, S. Nollet, N. Porchet, P. Degand, A. Laine et al., Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin, Biochem. J, issue.2, pp.338-325, 1999.

S. Nollet, N. Moniaux, J. Maury, D. Petitprez, P. Degand et al., Human mucin gene MUC4: organization of its 5???-region and polymorphism of its central tandem repeat array, Biochemical Journal, vol.332, issue.3, pp.332-739, 1998.
DOI : 10.1042/bj3320739

N. Porchet, V. C. Nguyen, J. Dufosse, J. P. Audie, V. Guyonnet-duperat et al., Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs, Biochemical and Biophysical Research Communications, vol.175, issue.2, pp.414-422, 1991.
DOI : 10.1016/0006-291X(91)91580-6

K. L. Carraway, G. Theodoropoulos, and G. Kozloski, Muc4/MUC4 functions and regulation in cancer, Future Oncology, vol.5, issue.10, pp.1631-1640, 2009.
DOI : 10.2217/fon.09.125

S. Jepson, M. Komatsu, B. Haq, M. E. Arango, D. Huang et al., Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27kip, but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways, Oncogene, vol.21, issue.49, pp.7524-7532, 2002.
DOI : 10.1038/sj.onc.1205970

K. L. Carraway, V. P. Ramsauer, and B. Haq, Cell signaling through membrane mucins, BioEssays, vol.2, issue.1, pp.66-71, 2003.
DOI : 10.1002/bies.10201

P. Chaturvedi, A. P. Singh, S. Chakraborty, S. C. Chauhan, S. Bafna et al., MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells, MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells, pp.2065-2070, 2008.
DOI : 10.1158/0008-5472.CAN-07-6041

N. Moniaux, P. Chaturvedi, G. C. Varshney, J. L. Meza, J. F. Rodriguez-sierra et al., Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells, British Journal of Cancer, vol.265, issue.3, pp.345-357, 2007.
DOI : 10.1093/nar/30.4.e15

C. Balague, G. Gambus, C. Carrato, N. Porchet, J. P. Aubert et al., Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines, Gastroenterology, vol.106, issue.4, pp.1054-1061, 1994.
DOI : 10.1016/0016-5085(94)90767-6

D. A. Cano, N. S. Murcia, G. J. Pazour, and M. Hebrok, Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization, pp.3457-3467, 2004.

C. E. Pierreux, A. V. Poll, C. R. Kemp, F. Clotman, M. A. Maestro et al., The Transcription Factor Hepatocyte Nuclear Factor-6 Controls the Development of Pancreatic Ducts in the Mouse, Gastroenterology, vol.130, issue.2, pp.532-541, 2006.
DOI : 10.1053/j.gastro.2005.12.005

G. E. Kim, H. I. Bae, H. U. Park, S. F. Kuan, S. C. Crawley et al., Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas, Gastroenterology, vol.123, issue.4, pp.1052-1060, 2002.
DOI : 10.1053/gast.2002.36018

I. Van-seuningen, E. Leteurtre, and P. Pigny, Mucins in pancreas and hepato-biliary tract. Expression, regulation, biomarkers and therapy, The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, pp.233-248, 2008.

M. J. Swartz, S. K. Batra, G. C. Varshney, M. A. Hollingsworth, C. J. Yeo et al., MUC4 Expression Increases Progressively in Pancreatic Intraepithelial Neoplasia, MUC4 expression increases progressively in pancreatic intraepithelial neoplasia, pp.791-796, 2002.
DOI : 10.1309/7Y7N-M1WM-R0YK-M2VA

V. Fauquette, S. Aubert, S. Groux-degroote, B. Hemon, and N. Porchet, Transcription factor AP-2?? represses both the mucin MUC4 expression and pancreatic cancer cell proliferation, Carcinogenesis, vol.28, issue.11, pp.2305-2312, 2007.
DOI : 10.1093/carcin/bgm158
URL : https://hal.archives-ouvertes.fr/hal-00164934

C. A. Iacobuzio-donahue, R. Ashfaq, A. Maitra, N. V. Adsay, G. L. Shen-ong et al., Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies, Cancer Res, vol.63, pp.8614-8622, 2003.

N. Moniaux, W. M. Junker, A. P. Singh, A. M. Jones, and S. K. Batra, Characterization of Human Mucin MUC17: COMPLETE CODING SEQUENCE AND ORGANIZATION, Journal of Biological Chemistry, vol.281, issue.33, pp.23676-23685, 2006.
DOI : 10.1074/jbc.M600302200

N. Adsay, Role of MUC Genes and Mucins in Pancreatic Neoplasia, The American Journal of Gastroenterology, vol.10, issue.10, pp.2330-2332, 2006.
DOI : 10.1038/sj.onc.1207769

H. Ito, T. Endo, T. Oka, T. Matumoto, T. Abe et al., Mucin Expression Profile Is Related to Biological and Clinical Characteristics of Intraductal Papillary-Mucinous Tumors of the Pancreas, Pancreas, vol.30, issue.4, pp.96-102, 2005.
DOI : 10.1097/01.mpa.0000163358.90111.ab

N. V. Adsay, K. Merati, O. Basturk, C. Iacobuzio-donahue, E. Levi et al., Pathologically and Biologically Distinct Types of Epithelium in Intraductal Papillary Mucinous Neoplasms, The American Journal of Surgical Pathology, vol.28, issue.7, pp.839-848, 2004.
DOI : 10.1097/00000478-200407000-00001

A. Nakamura, M. Horinouchi, M. Goto, K. Nagata, K. Sakoda et al., New classification of pancreatic intraductal papillary-mucinous tumour by mucin expression: its relationship with potential for malignancy, The Journal of Pathology, vol.39, issue.12, pp.201-210, 2002.
DOI : 10.1002/path.1109

J. Luttges, B. Feyerabend, T. Buchelt, M. Pacena, and G. Kloppel, The Mucin Profile of Noninvasive and Invasive Mucinous Cystic Neoplasms of the Pancreas, The American Journal of Surgical Pathology, vol.26, issue.4, pp.466-471, 2002.
DOI : 10.1097/00000478-200204000-00008

T. Terada, T. Ohta, M. Sasaki, Y. Nakanuma, and Y. S. Kim, EXPRESSION OF MUC APOMUCINS IN NORMAL PANCREAS AND PANCREATIC TUMOURS, The Journal of Pathology, vol.145, issue.2, pp.160-165, 1996.
DOI : 10.1002/(SICI)1096-9896(199610)180:2<160::AID-PATH625>3.0.CO;2-A

M. Perrais, P. Pigny, M. P. Ducourouble, D. Petitprez, N. Porchet et al., Characterization of Human Mucin Gene MUC4 Promoter. IMPORTANCE OF GROWTH FACTORS AND PROINFLAMMATORY CYTOKINES FOR ITS REGULATION IN PANCREATIC CANCER CELLS, Journal of Biological Chemistry, vol.276, issue.33, pp.30923-30933, 2001.
DOI : 10.1074/jbc.M104204200

N. Jonckheere, V. Fauquette, L. Stechly, N. Saint-laurent, S. Aubert et al., Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2?? overexpression, British Journal of Cancer, vol.7, issue.4, pp.637-644, 2009.
DOI : 10.1158/0008-5472.CAN-07-5953
URL : https://hal.archives-ouvertes.fr/inserm-00410436

T. Oikawa and T. Yamada, Molecular biology of the Ets family of transcription factors, Gene, vol.303, pp.11-34, 2003.
DOI : 10.1016/S0378-1119(02)01156-3

V. Fauquette, M. Perrais, S. Cerulis, N. Jonckheere, M. P. Ducourouble et al., genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells, Biochemical Journal, vol.386, issue.1, pp.35-45, 2005.
DOI : 10.1042/BJ20040706

M. Andrianifahanana, A. P. Singh, C. Nemos, M. P. Ponnusamy, N. Moniaux et al., IFN-??-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-?? response, Oncogene, vol.60, issue.51, pp.7251-7261, 2007.
DOI : 10.1038/sj.onc.1210532

R. J. Akhurst and R. Derynck, TGF-beta signaling in cancer--a double-edged sword, Trends Cell. Biol, vol.11, pp.44-51, 2001.

A. Choudhury, R. K. Singh, N. Moniaux, T. H. El-metwally, J. P. Aubert et al., Retinoic Acid-dependent Transforming Growth Factor-??2-mediated Induction of MUC4 Mucin Expression in Human Pancreatic Tumor Cells Follows Retinoic Acid Receptor-?? Signaling Pathway, Journal of Biological Chemistry, vol.275, issue.43, pp.33929-33936, 2000.
DOI : 10.1074/jbc.M005115200

N. Jonckheere, M. Perrais, C. Mariette, S. K. Batra, J. P. Aubert et al., A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-?? in pancreatic carcinogenesis, Oncogene, vol.23, issue.34, pp.5729-5738, 2004.
DOI : 10.1038/sj.onc.1207769

M. Andrianifahanana, A. Agrawal, A. P. Singh, N. Moniaux, I. Van-seuningen et al., Synergistic induction of the MUC4 mucin gene by interferon-?? and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways, Oncogene, vol.269, issue.40, pp.6143-6154, 2005.
DOI : 10.1074/jbc.M011488200

R. Mcwilliams, W. E. Highsmith, K. G. Rabe, M. De-andrade, L. A. Tordsen et al., Cystic fibrosis transmembrane regulator gene carrier status is a risk factor for young onset pancreatic adenocarcinoma, Gut, vol.54, issue.11, pp.1661-1662, 2005.
DOI : 10.1136/gut.2005.074534

A. P. Singh, S. C. Chauhan, M. Andrianifahanana, N. Moniaux, J. L. Meza et al., MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms, Oncogene, vol.29, issue.1, pp.30-41, 2007.
DOI : 10.1038/sj.onc.1209764

J. J. Ho, S. Crawley, P. L. Pan, E. R. Farrelly, and Y. S. Kim, Secretion of MUC5AC mucin from pancreatic cancer cells in response to forskolin and VIP, Biochemical and Biophysical Research Communications, vol.294, issue.3, pp.680-686, 2002.
DOI : 10.1016/S0006-291X(02)00529-6

N. B. Prasad, A. V. Biankin, N. Fukushima, A. Maitra, S. Dhara et al., Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells, Cancer Research, vol.65, issue.5, pp.1619-1626, 2005.
DOI : 10.1158/0008-5472.CAN-04-1413

N. Jonckheere, M. Van-der-sluis, A. Velghe, M. P. Buisine, M. Sutmuller et al., Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1, Biochemical Journal, vol.377, issue.3, pp.797-808, 2004.
DOI : 10.1042/bj20030948

N. Jonckheere, A. Vincent, M. Perrais, M. P. Ducourouble, A. K. Male et al., The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells, Journal of Biological Chemistry, vol.282, issue.31, pp.22638-22650, 2007.
DOI : 10.1074/jbc.M700905200

M. Van-der-sluis, M. H. Melis, N. Jonckheere, M. P. Ducourouble, H. A. Buller et al., The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells, Biochemical and Biophysical Research Communications, vol.325, issue.3, pp.952-960, 2004.
DOI : 10.1016/j.bbrc.2004.10.108

M. Van-der-sluis, A. Vincent, J. Bouma, A. Korteland-van-male, J. B. Van-goudoever et al., Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells, Biochemical and Biophysical Research Communications, vol.369, issue.4, pp.1108-1113, 2008.
DOI : 10.1016/j.bbrc.2008.02.158

I. Van-seuningen, Qu???est ce que l?????pig??n??tique??? Strat??gies d?????tude et application au cancer, Annales de Pathologie, vol.29, issue.5, pp.28-30, 2009.
DOI : 10.1016/j.annpat.2009.07.009

A. Vincent, Van Seuningen, I. Mucins, epigenetics and cancer. In The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, pp.95-108, 2008.

I. Van-seuningen and A. Vincent, Mucins: a new family of epigenetic biomarkers in epithelial cancers, Expert Opinion on Medical Diagnostics, vol.22, issue.4, pp.411-427, 2009.
DOI : 10.1042/bj3480675

N. Yamada, Y. Nishida, H. Tsutsumida, T. Hamada, M. Goto et al., MUC1 Expression Is Regulated by DNA Methylation and Histone H3 Lysine 9 Modification in Cancer Cells, Cancer Research, vol.68, issue.8, pp.2708-2716, 2008.
DOI : 10.1158/0008-5472.CAN-07-6844

A. Vincent and M. P. Ducourouble, Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases, The FASEB Journal, vol.22, issue.8, pp.3035-3045, 2008.
DOI : 10.1096/fj.07-103390

N. Yamada, Y. Nishida, H. Tsutsumida, M. Goto, M. Higashi et al., Promoter CpG methylation in cancer cells contributes to the regulation of MUC4, British Journal of Cancer, vol.20, issue.2, pp.344-351, 2009.
DOI : 10.1111/j.1440-1827.1997.tb03713.x

A. De-bustros, B. D. Nelkin, A. Silverman, G. Ehrlich, B. Poiesz et al., The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia., Proc. Natl. Acad. Sci, pp.5693-5697, 1988.
DOI : 10.1073/pnas.85.15.5693

J. J. Ho, S. W. Han, P. L. Pan, G. Deng, S. F. Kuan et al., Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells, International Journal of Oncology, vol.22, pp.273-279, 2003.
DOI : 10.3892/ijo.22.2.273

A. Vincent, M. Perrais, J. L. Desseyn, J. P. Aubert, and P. Pigny, Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells, epithelial cancer cells, pp.6566-6576, 2007.
DOI : 10.1002/ijc.22047

T. Hamada, M. Goto, H. Tsutsumida, M. Nomoto, M. Higashi et al., Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. Cancer Lett, pp.175-184, 2005.

N. Yamada, Y. Nishida, S. Yokoyama, H. Tsutsumida, I. Houjou et al., Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells, Journal of Hepato-Biliary-Pancreatic Sciences, vol.7, issue.6, pp.844-854, 2010.
DOI : 10.1007/s00534-010-0278-0

N. Yamada, T. Hamada, M. Goto, H. Tsutsumida, M. Higashi et al., MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer, International Journal of Cancer, vol.64, issue.8, pp.1850-1857, 2006.
DOI : 10.1002/ijc.22047

C. Jin and H. Rajabi, Kufe, D. miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death, Int. J. Oncol, vol.37, pp.61-69, 2010.

H. Rajabi, C. Jin, R. Ahmad, C. Mcclary, M. D. Joshi et al., Mucin 1 Oncoprotein Expression Is Suppressed by the miR-125b Oncomir, Genes & Cancer, vol.1, issue.1, pp.62-68, 2010.
DOI : 10.1177/1947601909357933

M. Sachdeva and Y. Mo, MicroRNA-145 Suppresses Cell Invasion and Metastasis by Directly Targeting Mucin 1, Cancer Research, vol.70, issue.1, pp.378-387, 2010.
DOI : 10.1158/0008-5472.CAN-09-2021

L. C. Fry, K. Monkemuller, and P. Malfertheiner, Molecular markers of pancreatic cancer: development and clinical relevance, Langenbeck's Archives of Surgery, vol.49, issue.6, pp.883-890, 2008.
DOI : 10.1007/s00423-007-0276-0

W. Grizzle, Biomarkers in Diagnosis of pancreatic carcinoma in fine-needle aspirates, Am. J. Clin. Pathol, vol.126, pp.572-579, 2006.

D. V. Gold, Z. Karanjawala, D. E. Modrak, D. M. Goldenberg, and R. H. Hruban, PAM4-Reactive MUC1 Is a Biomarker for Early Pancreatic Adenocarcinoma, Clinical Cancer Research, vol.13, issue.24, pp.7380-7387, 2007.
DOI : 10.1158/1078-0432.CCR-07-1488

B. B. Haab, A. Porter, T. Yue, L. Li, J. Scheiman et al., Glycosylation Variants of Mucins and CEACAMs As Candidate Biomarkers for the Diagnosis of Pancreatic Cystic Neoplasms, Annals of Surgery, vol.251, issue.5, pp.937-945, 2010.
DOI : 10.1097/SLA.0b013e3181d7738d

C. K. Tang and V. Apostolopoulos, Strategies used for MUC1 immunotherapy: preclinical studies, Expert Review of Vaccines, vol.7, issue.7, pp.951-962, 2008.
DOI : 10.1586/14760584.7.7.951

C. K. Tang, M. Katsara, and V. Apostolopoulos, Strategies used for MUC1 immunotherapy: human clinical studies, Expert Review of Vaccines, vol.7, issue.7, pp.963-975, 2008.
DOI : 10.1586/14760584.7.7.963

B. G. Bitler, I. Menzl, C. L. Huerta, B. Sands, W. Knowlton et al., Intracellular MUC1 Peptides Inhibit Cancer Progression, Clinical Cancer Research, vol.15, issue.1, pp.100-109, 2009.
DOI : 10.1158/1078-0432.CCR-08-1745

L. Chen, Q. Liu, R. Qin, H. Le, R. Xia et al., Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro, International Journal of Molecular Medicine, vol.15, pp.617-626, 2005.
DOI : 10.3892/ijmm.15.4.617

J. Wei, W. Gao, J. Wu, K. Meng, J. Zhang et al., Dendritic Cells Expressing a Combined PADRE/MUC4-Derived Polyepitope DNA Vaccine Induce Multiple Cytotoxic T-Cell Responses, Cancer Biotherapy & Radiopharmaceuticals, vol.23, issue.1, pp.121-128, 2008.
DOI : 10.1089/cbr.2007.0427

S. Bafna, S. Kaur, N. Momi, and S. K. Batra, Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin, British Journal of Cancer, vol.65, issue.7, pp.1155-1161, 2009.
DOI : 10.1016/0092-8674(95)90411-5

M. Mimeault, S. L. Johansson, S. Senapati, N. Momi, S. Chakraborty et al., MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. Cancer Lett, 2010.

A. V. Kalra and R. B. Campbell, Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain, British Journal of Cancer, vol.7, issue.7, pp.910-918, 2007.
DOI : 10.1007/s005340200037

A. V. Kalra and R. B. Campbell, Mucin overexpression limits the effectiveness of 5-FU by reducing intracellular drug uptake and antineoplastic drug effects in pancreatic tumours, European Journal of Cancer, vol.45, issue.1, pp.164-173, 2008.
DOI : 10.1016/j.ejca.2008.10.008

T. L. Tinder, D. B. Subramani, G. D. Basu, J. M. Bradley, J. Schettini et al., MUC1 Enhances Tumor Progression and Contributes Toward Immunosuppression in a Mouse Model of Spontaneous Pancreatic Adenocarcinoma, The Journal of Immunology, vol.181, issue.5, pp.3116-3125, 2008.
DOI : 10.4049/jimmunol.181.5.3116

A. P. Spicer, T. Duhig, B. S. Chilton, and S. J. Gendler, Analysis of mammalian MUC1 genes reveals potential functionally important domains, Mammalian Genome, vol.356, issue.12, pp.885-888, 1995.
DOI : 10.1007/BF00292441

E. N. Lalani, F. Berdichevsky, M. Boshell, M. Shearer, D. Wilson et al., Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity, J. Biol. Chem, vol.266, pp.15420-15426, 1991.

A. J. Aguirre, N. Bardeesy, M. Sinha, L. Lopez, D. A. Tuveson et al., Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma, Genes & Development, vol.17, issue.24, pp.3112-3126, 2003.
DOI : 10.1101/gad.1158703

S. R. Hingorani, E. F. Petricoin, A. Maitra, V. Rajapakse, C. King et al., Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse, Cancer Cell, vol.4, issue.6, pp.437-450, 2003.
DOI : 10.1016/S1535-6108(03)00309-X

S. R. Hingorani, L. Wang, A. S. Multani, C. Combs, T. B. Deramaudt et al., Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice, Cancer Cell, vol.7, issue.5, pp.469-483, 2005.
DOI : 10.1016/j.ccr.2005.04.023

K. Izeradjene, C. Combs, M. Best, A. Gopinathan, A. Wagner et al., KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas, Cancer Cell, vol.11, issue.3, pp.229-243, 2007.
DOI : 10.1016/j.ccr.2007.01.017

A. Velcich, W. Yang, J. Heyer, A. Fragale, C. Nicholas et al., Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2, Science, vol.295, issue.5560, pp.1726-1729, 2002.
DOI : 10.1126/science.1069094

D. J. Cheon, Y. Wang, J. M. Deng, Z. Lu, L. Xiao et al., CA125/MUC16 Is Dispensable for Mouse Development and Reproduction, PLoS ONE, vol.93, issue.10, p.4675, 2009.
DOI : 10.1371/journal.pone.0004675.s003