Skip to Main content Skip to Navigation
Journal articles

Mucins and Pancreatic Cancer

Nicolas Jonckheere 1, * Nicolas Skrypek 1 Isabelle van Seuningen 1
* Corresponding author
1 Inserm UMR837 Team 5
Centre de recherche Jean-Pierre Aubert-Neurosciences et Cancer
Abstract : Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting the epithelia whereas membrane-bound mucins are thought to play important biological roles in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cells. In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. Moreover, we will discuss the recent advances about the biology of both secreted and membrane-bound mucins and their key roles in pancreatic carcinogenesis and resistance to therapy. Finally, we will discuss exciting opportunities that mucins offer as potential therapeutic targets in pancreatic cancer.
Document type :
Journal articles
Complete list of metadatas

Cited literature [98 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00807873
Contributor : Nicolas Jonckheere <>
Submitted on : Thursday, April 4, 2013 - 3:10:38 PM
Last modification on : Tuesday, November 24, 2020 - 9:58:03 AM
Long-term archiving on: : Friday, July 5, 2013 - 4:18:20 AM

File

cancers-02-01794-manuscript-v2...
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Nicolas Jonckheere, Nicolas Skrypek, Isabelle van Seuningen. Mucins and Pancreatic Cancer. Cancers, MDPI, 2010, 2, pp.1794-1812. ⟨10.3390/cancers2041794⟩. ⟨inserm-00807873⟩

Share

Metrics

Record views

310

Files downloads

439