N. Jonckheere, N. Skrypek, and I. Van-seuningen, Mucins and Pancreatic Cancer, Cancers, vol.2, issue.4, pp.1794-1812, 2010.
DOI : 10.3390/cancers2041794
URL : https://hal.archives-ouvertes.fr/inserm-00807873

N. Jonckheere and I. Van-seuningen, The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers, Biochimie, vol.92, issue.1, pp.1-11, 2010.
DOI : 10.1016/j.biochi.2009.09.018

D. W. Kufe, Mucins in cancer: function, prognosis and therapy, Nature Reviews Cancer, vol.34, issue.12, pp.874-885, 2009.
DOI : 10.1038/nrc2761
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951677

N. Jonckheere and I. Van-seuningen, The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies, Critical Reviews??? in Oncogenesis, vol.14, issue.2-3, pp.177-196, 2008.
DOI : 10.1615/CritRevOncog.v14.i2-3.30

M. A. Hollingsworth and B. J. Swanson, Mucins in cancer: protection and control of the cell surface, Nature Reviews Cancer, vol.4, issue.1, pp.45-60, 2004.
DOI : 10.1038/nrc1251

I. Van-seuningen, P. Pigny, M. Perrais, N. Porchet, and J. P. Aubert, Transcriptional regulation of the 11p15 mucin genes towards new biological tools in human therapy in inflammatory diseases and cancer, Frontiers in Bioscience, vol.6, issue.3, pp.1216-1234, 2001.
DOI : 10.2741/A675

S. K. Linden, P. Sutton, N. G. Karlsson, V. Korolik, and M. A. Mcguckin, Mucins in the mucosal barrier to infection, Mucosal Immunology, vol.68, issue.3, pp.183-197, 2008.
DOI : 10.1038/mi.2008.5

N. Jonckheere and I. Van-seuningen, The ever growing family of membrane-bound mucins

I. Van-seuningen, The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, Research Signpost, vol.9, pp.17-38, 2008.

J. L. Desseyn, D. Tetaert, and V. Gouyer, Architecture of the large membrane-bound mucins, Gene, vol.410, issue.2, pp.215-222, 2008.
DOI : 10.1016/j.gene.2007.12.014

Y. Kobashi, Y. Taguchi, A. Azuma, S. Kudoh, and N. Keicho, Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis, Hum Genet, vol.12911, pp.117-128, 2011.

J. Dekker, J. W. Rossen, H. A. Buller, and A. W. Einerhand, The MUC family: an obituary, Trends in Biochemical Sciences, vol.27, issue.3, pp.126-131, 2002.
DOI : 10.1016/S0968-0004(01)02052-7

N. Moniaux, F. Escande, N. Porchet, J. P. Aubert, and S. K. Batra, Structural organization and classification of the human mucin genes, Frontiers in Bioscience, vol.6, issue.1, pp.1192-1206, 2001.
DOI : 10.2741/Moniaux

S. Duraisamy, S. Ramasamy, S. Kharbanda, and D. Kufe, Distinct evolution of the human carcinoma-associated transmembrane mucins, Gene, vol.37314, pp.28-34, 2006.

S. Duraisamy, T. Kufe, S. Ramasamy, and D. Kufe, Evolution of the human MUC1 oncoprotein, International Journal of Oncology, vol.3115, pp.671-677, 2007.
DOI : 10.3892/ijo.31.3.671

J. Fowler, L. Vinall, D. Swallow, S. Groux-degroote, A. Harduin-lepers et al., Polymorphism of the human muc genes Biosynthesis of mucin O-glycan chains in normal and pathological states The Epithelial Mucins: Structure/Function, Roles in Cancer and Inflammatory Diseases, pp.1207-1215, 2001.

H. S. Silverman, M. Sutton-smith, K. Mcdermott, P. Heal, S. H. Leir et al., The contribution of tandem repeat number to the O-glycosylation of mucins Tumour-associated antigens of mucin Oglycans . Clinical relevance of glycobiology in cancer and inflammatory diseases of the epithelium, The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, pp.265-277, 2003.

I. Brockhausen, Pathways of O-glycan biosynthesis in cancer cells, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1473, issue.1, pp.67-95, 1999.
DOI : 10.1016/S0304-4165(99)00170-1

I. Brockhausen, Sulphotransferases acting on mucin-type oligosaccharides, Biochemical Society Transactions, vol.31, issue.2, pp.318-325, 2003.
DOI : 10.1042/bst0310318

J. J. Rahn, J. W. Chow, G. J. Horne, B. K. Mah, J. T. Emerman et al., MUC1 Mediates Transendothelial Migration in vitro by Ligating Endothelial Cell ICAM-1, Clinical & Experimental Metastasis, vol.272, issue.Pt 1, pp.475-483, 2005.
DOI : 10.1007/s10585-005-3098-x

S. Senapati, S. Das, and S. K. Batra, Mucin-interacting proteins: from function to therapeutics, Trends in Biochemical Sciences, vol.35, issue.4, pp.236-245, 2010.
DOI : 10.1016/j.tibs.2009.10.003
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030310

S. Senapati, P. Chaturvedi, W. G. Chaney, S. Chakraborty, V. S. Gnanapragassam et al., Novel Interaction of MUC4 and Galectin: Potential Pathobiological Implications for Metastasis in Lethal Pancreatic Cancer, Clinical Cancer Research, vol.17, issue.2, pp.267-274, 2011.
DOI : 10.1158/1078-0432.CCR-10-1937

Q. Zhao, X. Guo, G. B. Nash, P. C. Stone, J. Hilkens et al., Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface, Cancer Research, vol.69, issue.17, pp.69-6799, 2009.
DOI : 10.1158/0008-5472.CAN-09-1096
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741610

Q. Zhao, M. Barclay, J. Hilkens, X. Guo, H. Barrow et al., Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis, Molecular Cancer, vol.9, issue.1, 2010.
DOI : 10.1186/1476-4598-9-154
URL : http://doi.org/10.1186/1476-4598-9-154

J. Merlin, L. Stechly, S. De-beauce, D. Monte, E. Leteurtre et al., Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells, Oncogene, vol.9, issue.1, pp.2514-2525, 2011.
DOI : 10.1038/onc.2010.631

K. L. Carraway, V. P. Ramsauer, B. Haq, C. Carraway, and C. A. , Cell signaling through membrane mucins, BioEssays, vol.2, issue.1, pp.66-71, 2003.
DOI : 10.1002/bies.10201

J. L. Desseyn, C. Susini, F. Frenois, and I. Van-seuningen, The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways, PLoS One, vol.729, p.32232, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00807830

Y. Luu, W. Junker, S. Rachagani, S. Das, S. K. Batra et al., Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis, The International Journal of Biochemistry & Cell Biology, vol.42, issue.6, pp.996-1006, 2010.
DOI : 10.1016/j.biocel.2010.03.001

S. B. Ho, Y. Luu, L. L. Shekels, S. K. Batra, B. Kandarian et al., Activity of recombinant cysteine-rich domain proteins derived from the membrane-bound MUC17/Muc3 family mucins, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1800, issue.7, pp.1800-629, 2010.
DOI : 10.1016/j.bbagen.2010.03.010

L. A. Kelley and M. J. Sternberg, Protein structure prediction on the Web: a case study using the Phyre server, Nature Protocols, vol.5, issue.3, pp.363-371, 2009.
DOI : 10.1093/nar/gkm977

S. Parry, H. S. Silverman, K. Mcdermott, A. Willis, M. A. Hollingsworth et al., Identification of MUC1 proteolytic cleavage sites in vivo The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins, Biochem Biophys Res Commun Febs J, vol.2837203334, issue.715, pp.272-2901, 2001.

P. Bork and L. Patthy, The SEA module: a new extracellular domain associated with Oglycosylation, Protein Sci, vol.435, pp.1421-1425, 1995.

B. Macao, D. G. Johansson, G. C. Hansson, and T. Hard, Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin, Nature Structural & Molecular Biology, vol.22, issue.1, pp.71-76, 2006.
DOI : 10.1038/nsmb1035

F. Levitin, O. Stern, M. Weiss, C. Gil-henn, R. Ziv et al., The MUC1 SEA Module Is a Self-cleaving Domain, Journal of Biological Chemistry, vol.280, issue.39, pp.33374-33386, 2005.
DOI : 10.1074/jbc.M506047200

S. Senapati, V. S. Gnanapragassam, N. Moniaux, N. Momi, and S. K. Batra, Role of MUC4???NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells, Oncogene, vol.170, issue.28, pp.3346-3356, 2012.
DOI : 10.1038/onc.2011.505

G. Ramadori, Expression of ECM proteins fibulin-1 and -2 in acute and chronic liver disease and in cultured rat liver cells, Cell Tissue Res, vol.33740, pp.449-462, 2009.

W. Xiang, Z. Ke, Y. Zhang, G. H. Cheng, I. D. Irwan et al., Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice, Journal of Cellular and Molecular Medicine, vol.132, issue.2, pp.359-374, 2011.
DOI : 10.1111/j.1582-4934.2009.00961.x

T. Lang, G. C. Hansson, and T. Samuelsson, Gel-forming mucins appeared early in metazoan evolution, Proceedings of the National Academy of Sciences, vol.104, issue.41, pp.16209-16214, 2007.
DOI : 10.1073/pnas.0705984104

J. L. Desseyn, V. Gouyer, and D. Tetaert, Architecture of the gel-forming mucins

I. Seuningen, The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases, Research Signpost, vol.43, pp.1-16, 2008.

J. L. Desseyn, I. Clavereau, and A. Laine, Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4, Eur J Biochem, vol.26944, pp.3150-3159, 2002.

M. I. Hassan, A. Saxena, and F. Ahmad, Structure and function of von Willebrand factor, Blood Coagulation & Fibrinolysis, vol.23, issue.1, pp.11-22, 2012.
DOI : 10.1097/MBC.0b013e32834cb35d

C. L. Hattrup and S. J. Gendler, Structure and Function of the Cell Surface (Tethered) Mucins, Annual Review of Physiology, vol.70, issue.1, pp.431-457, 2008.
DOI : 10.1146/annurev.physiol.70.113006.100659

D. D. Carson, The Cytoplasmic Tail of MUC1: A Very Busy Place, Science Signaling, vol.1, issue.27, pp.35-47, 2008.
DOI : 10.1126/scisignal.127pe35

D. W. Kufe, Functional targeting of the MUC1 oncogene in human cancers, Cancer Biology & Therapy, vol.8, issue.13, pp.1197-1203, 2009.
DOI : 10.4161/cbt.8.13.8844

R. D. Ahmad, R. Kumar, S. Ren, J. Yoshida, K. Kharbanda et al., MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage, Embo J, vol.2549, pp.3774-3783, 2006.

P. Pandey, S. Kharbanda, and D. Kufe, Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein, Cancer Res, vol.5550, pp.4000-4003, 1995.

R. Ahmad, D. Raina, M. D. Joshi, T. Kawano, J. Ren et al., MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor, Cancer Res, vol.52, pp.69-7013, 2009.

J. Ren, A. Bharti, D. Raina, W. Chen, R. Ahmad et al., MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90, Oncogene, vol.112, pp.20-31, 2006.
DOI : 10.1038/sj.onc.1209012

Y. Wen, T. C. Caffrey, M. J. Wheelock, K. R. Johnson, and M. A. Hollingsworth, Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin, J Biol Chem, vol.27854, pp.38029-38039, 2003.

J. Ren, D. Raina, W. Chen, G. Li, L. Huang et al., MUC1 Oncoprotein Functions in Activation of Fibroblast Growth Factor Receptor Signaling, Molecular Cancer Research, vol.4, issue.11, pp.873-883, 2006.
DOI : 10.1158/1541-7786.MCR-06-0204

P. K. Singh, Y. Wen, B. J. Swanson, K. Shanmugam, A. Kazlauskas et al., Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells, Cancer Res, vol.56, pp.67-5201, 2007.

Y. Leng, C. Cao, J. Ren, L. Huang, D. Chen et al., Nuclear Import of the MUC1-C Oncoprotein Is Mediated by Nucleoporin Nup62, Journal of Biological Chemistry, vol.282, issue.27, pp.19321-19330, 2007.
DOI : 10.1074/jbc.M703222200

R. D. Ahmad, R. Rajabi, H. Panchamoorthy, G. Kharbanda, S. Kufe et al., Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells, Int J Oncol, vol.4058, pp.1643-1649, 2012.

X. Wei, H. Xu, and D. Kufe, MUC1 oncoprotein stabilizes and activates estrogen receptor alpha, Mol Cell, vol.2159, pp.295-305, 2006.
DOI : 10.1016/j.molcel.2005.11.030
URL : http://doi.org/10.1016/j.molcel.2005.11.030

H. Sabe, H. Hanafusa, and T. Yi, Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps, Mol Cell Biol, vol.1460, pp.2777-2785, 1994.

D. M. Maher, B. K. Gupta, S. Nagata, M. Jaggi, and S. C. Chauhan, Mucin 13: Structure, Function, and Potential Roles in Cancer Pathogenesis, Molecular Cancer Research, vol.9, issue.5, pp.531-53761, 2011.
DOI : 10.1158/1541-7786.MCR-10-0443
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017946

I. K. Gipson, Functions of MUC16 in corneal epithelial cells, Invest Ophthalmol Vis Sci, vol.4862, pp.4509-4518, 2007.

I. Lakshmanan, M. P. Ponnusamy, S. Das, S. Chakraborty, D. Haridas et al., MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells, Oncogene, vol.426, issue.7, pp.805-817, 2012.
DOI : 10.1038/onc.2011.297

E. K. Malmberg, T. Pelaseyed, A. C. Petersson, U. E. Seidler, H. De-jonge et al., The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine, Biochemical Journal, vol.410, issue.2, pp.410-283, 2008.
DOI : 10.1042/BJ20071068
URL : https://hal.archives-ouvertes.fr/hal-00478867

T. Higuchi, T. Orita, K. Katsuya, Y. Yamasaki, K. Akiyama et al., MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor-potentiating function, Mol Cell Biol Int J Cancer, vol.246566, issue.71, pp.7456-7468, 1997.

S. Licht, S. Shina, A. Gat, B. Lifschitz, M. Simha et al., A novel protein derived from the MUC1 gene by alternative splicing and frameshifting Antitumor effects of Mucin 1/sec involves the modulation of urokinase-type plasminogen activator and signal transducer and activator of transcription 1 expression in tumor cells, J Biol Chem Cancer Res Blood, vol.2806769, issue.113, pp.10655-10663, 2005.

N. Moniaux, F. Escande, S. K. Batra, N. Porchet, A. Laine et al., Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins, European Journal of Biochemistry, vol.335, issue.14, pp.4536-4544, 2000.
DOI : 10.1046/j.1432-1327.2000.01504.x

F. Escande, L. Lemaitre, N. Moniaux, S. K. Batra, J. P. Aubert et al., Genomic organization of MUC4 mucin gene. Towards the characterization of splice variants, Eur J Biochem, vol.26971, pp.3637-3644, 2002.

S. C. Crawley, J. R. Gum, . Jr, J. W. Hicks, W. S. Pratt et al., Genomic Organization and Structure of the 3??? Region of Human MUC3: Alternative Splicing Predicts Membrane-Bound and Soluble Forms of the Mucin, Biochemical and Biophysical Research Communications, vol.263, issue.3, pp.728-736, 1999.
DOI : 10.1006/bbrc.1999.1466

S. J. Williams, D. J. Munster, R. J. Quin, D. C. Gotley, and M. A. Mcguckin, The MUC3 Gene Encodes a Transmembrane Mucin and Is Alternatively Spliced, Biochemical and Biophysical Research Communications, vol.261, issue.1, pp.83-89, 1999.
DOI : 10.1006/bbrc.1999.1001

N. Moniaux, W. M. Junker, A. P. Singh, A. M. Jones, and S. K. Batra, Characterization of Human Mucin MUC17: COMPLETE CODING SEQUENCE AND ORGANIZATION, Journal of Biological Chemistry, vol.281, issue.33, pp.23676-23685, 2006.
DOI : 10.1074/jbc.M600302200

D. W. Kufe, MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches, Oncogene, vol.8, issue.9
DOI : 10.1038/onc.2012.158

B. G. Bitler, I. Menzl, C. L. Huerta, B. Sands, W. Knowlton et al., Intracellular MUC1 Peptides Inhibit Cancer Progression, Clinical Cancer Research, vol.15, issue.1, pp.100-109, 2009.
DOI : 10.1158/1078-0432.CCR-08-1745
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676873

C. M. Klinge, B. N. Radde, Y. Imbert-fernandez, Y. Teng, M. M. Ivanova et al., Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells, Molecular Cancer Therapeutics, vol.10, issue.11, pp.2062-2071, 2011.
DOI : 10.1158/1535-7163.MCT-11-0381

D. Kufe, C. K. Tang, M. Katsara, V. Apostolopoulos, C. K. Tang et al., Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells Strategies used for MUC1 immunotherapy: human clinical studies Strategies used for MUC1 immunotherapy: preclinical studies, Cancer Res Expert Rev Vaccines Expert Rev Vaccines, vol.6980, issue.7, pp.5133-5141, 2008.

C. S. Madsen, P. A. Cohen, S. J. Gendler, and G. J. Boons, Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine, Proc Natl Acad Sci U S A, vol.10981, pp.261-266, 2011.

T. Mukohara, Mechanisms of resistance to anti-human epidermal growth factor receptor 2 agents in breast cancer, Cancer Science, vol.70, issue.Suppl 1, pp.1-8, 2011.
DOI : 10.1111/j.1349-7006.2010.01711.x

P. Nagy, E. Friedlander, M. Tanner, A. I. Kapanen, K. L. Carraway et al., Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4- expressing breast cancer cell line, Cancer Res, vol.83, pp.65-473, 2005.

N. Skrypek, B. Duchêne, M. Hebbar, E. Leteurtre, I. Van-seuningen et al., The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family, Oncogene, vol.377, issue.13, p.179, 2012.
DOI : 10.1038/onc.2012.179
URL : https://hal.archives-ouvertes.fr/inserm-00807837

L. Holm and M. Phillipson, Importance and regulation of the colonic mucus barrier in a mouse model of colitis, Am J Physiol Gastrointest Liver Physiol, vol.300, pp.327-333, 2011.