Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity.

Gaël Chételat 1, * Brigitte Landeau 1 Eric Salmon 2 Igor Yakushev 3, 4 Mohamed Ali Bahri 2 Florence Mézenge 1 Audrey Perrotin 1 Christine Bastin 2 Alain Manrique 5 Armin Scheurich 3 Mathias Scheckenberger 6 Béatrice Desgranges 1 Francis Eustache 1 Andreas Fellgiebel 4
* Auteur correspondant
1 Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine
2 Cyclotron Research Centre
3 Department of Psychiatry and Psychotherapy
4 Department of Nuclear Medicine
5 Service de médecine nucléaire [Caen]
6 Department of Nuclear Medicine
Abstract : Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related alteration of white matter (WM) structural integrity and/or functional connectivity. FDG-PET data from 40 young and 57 elderly healthy participants from two research centers (n=49/48 in Center 1/2) were analyzed. WM volume from T1-weighted MRI (Center 1), fractional anisotropy from diffusion-tensor imaging (Center 2), and resting-state fMRI data (Center 1) were also obtained. Group comparisons were performed within each imaging modality. Then, positive correlations were assessed, within the elderly, between metabolism in the most affected region and the other neuroimaging modalities. Metabolism decline in the elderly predominated in the left inferior frontal junction (LIFJ). LIFJ hypometabolism was significantly associated with macrostructural and microstructural WM disturbances in long association fronto-temporo-occipital fibers, while no relationship was found with functional connectivity. The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between age-related metabolism and connectivity changes.
Keywords : frontal cortex. normal aging connectivity diffusion tensor imaging resting-state fMRI FDG-PET metabolism frontal cortex
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Article dans une revue
NeuroImage, Elsevier, 2013, 76, pp.167-77. 〈10.1016/j.neuroimage.2013.03.009〉
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Gaël Chételat, Brigitte Landeau, Eric Salmon, Igor Yakushev, Mohamed Ali Bahri, et al.. Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity.. NeuroImage, Elsevier, 2013, 76, pp.167-77. 〈10.1016/j.neuroimage.2013.03.009〉. 〈inserm-00806846〉

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