L. Hourigan, G. Macdonald, D. Purdie, V. Whitehall, and C. Shorthouse, Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis, Hepatology, vol.29, issue.4, pp.1215-1219, 1999.
DOI : 10.1002/hep.510290401

L. Adinolfi, M. Gambardella, A. A. Tripodi, M. Utili, R. Ruggiero et al., Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity, Hepatology, vol.33, issue.6, pp.1358-1364, 2001.
DOI : 10.1053/jhep.2001.24432

P. Roingeard and H. Hourioux, Hepatitis C virus core protein, lipid droplets and steatosis, Journal of Viral Hepatitis, vol.87, issue.3, pp.157-164, 2008.
DOI : 10.1111/j.1365-2893.2007.00953.x

URL : https://hal.archives-ouvertes.fr/inserm-00211731

M. Depla, R. Uzbekov, C. Hourioux, E. Blanchard, L. Gouge et al., Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein, Cellular and Molecular Life Sciences, vol.132, issue.18, pp.3151-3161, 2010.
DOI : 10.1007/s00018-010-0373-z

URL : https://hal.archives-ouvertes.fr/hal-00512808

S. Boulant, M. Douglas, L. Moody, A. Budkowska, P. Targett-adams et al., Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule- and Dynein-Dependent Manner, Traffic, vol.278, issue.8, pp.1268-1282, 2008.
DOI : 10.1111/j.1600-0854.2008.00767.x

A. Wang, D. Lee, H. Moon, J. Kim, and K. Cho, Non-structural 5A protein of hepatitis C virus induces a range of liver pathology in transgenic mice, The Journal of Pathology, vol.317, issue.2, pp.253-262, 2009.
DOI : 10.1002/path.2592

K. Kim, K. Kim, E. Ha, J. Park, N. Sakamoto et al., Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma, FEBS Letters, vol.278, issue.17, pp.2720-2726, 2009.
DOI : 10.1016/j.febslet.2009.07.034

W. Benga, S. Krieger, M. Dimitrova, M. Zeisel, and M. Parnot, Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles, Hepatology, vol.47, issue.2 Suppl 1, pp.43-53, 2010.
DOI : 10.1002/hep.23278

URL : https://hal.archives-ouvertes.fr/inserm-00705655

P. Simmonds, J. Bukh, C. Combet, G. Deléage, and N. Enomoto, Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes, Hepatology, vol.17, issue.4, pp.962-973, 2005.
DOI : 10.1002/hep.20819

URL : https://hal.archives-ouvertes.fr/hal-00313678

T. Poynard, V. Ratziu, J. Mchutchison, M. Manns, and Z. Goodman, Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C, Hepatology, vol.26, issue.1, pp.75-85, 2003.
DOI : 10.1053/jhep.2003.50267

L. Rubbia-brandt, R. Quadri, K. Abid, E. Giostra, and P. Malé, Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3, Journal of Hepatology, vol.33, issue.1, pp.106-115, 2000.
DOI : 10.1016/S0168-8278(00)80166-X

H. Hofer, H. Bankl, F. Wrba, P. Steindl-munda, and M. Peck-radosavjevic, Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a, The American Journal of Gastroenterology, vol.28, issue.11, pp.2880-2885, 2002.
DOI : 10.1016/S0140-6736(95)91685-7

C. Hourioux, R. Patient, A. Morin, E. Blanchard, and A. Moreau, The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model, Gut, vol.56, issue.9, pp.1302-1308, 2007.
DOI : 10.1136/gut.2006.108647

URL : https://hal.archives-ouvertes.fr/inserm-00167783

A. Piodi, P. Chouteau, H. Lerat, C. Hézode, and J. Pawlotsky, Morphological changes in intracellular lipid droplets induced by different hepatitis C virus genotype core sequences and relationship with steatosis, Hepatology, vol.15, issue.1, pp.16-27, 2008.
DOI : 10.1002/hep.22288

URL : https://hal.archives-ouvertes.fr/inserm-00304349

R. Jhaveri, J. Mchutchison, K. Patel, G. Qiang, and A. Diehl, Specific Polymorphisms in Hepatitis C Virus Genotype 3 Core Protein Associated with Intracellular Lipid Accumulation, The Journal of Infectious Diseases, vol.197, issue.2, pp.283-291, 2008.
DOI : 10.1086/524846

K. Tamura, D. Peterson, N. Peterson, G. Stecher, M. Nei et al., MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods, Molecular Biology and Evolution, vol.28, issue.10, pp.2731-2739, 2011.
DOI : 10.1093/molbev/msr121

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203626

D. Siagris, M. Christofidou, G. Theocharis, N. Pagoni, and C. Papadimitriou, Serum lipid pattern in chronic hepatitis C: histological and virological correlations, Journal of Viral Hepatitis, vol.78, issue.5, pp.56-61, 2006.
DOI : 10.1016/S0168-8278(00)00036-2

M. Eslam, T. Kawaguchi, D. Campo, A. Sata, and M. Abo-, Use of HOMA-IR in hepatitis C, Journal of Viral Hepatitis, vol.21, issue.6, pp.675-684, 2011.
DOI : 10.1111/j.1365-2893.2011.01474.x

T. Masaki, R. Suzuki, K. Murakami, H. Aizaki, and K. Ishii, Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles, Journal of Virology, vol.82, issue.16, pp.7964-7976, 2008.
DOI : 10.1128/JVI.00826-08

T. Fujimoto, Y. Ohsaki, J. Cheng, M. Suzuki, and Y. Shinohara, Lipid droplets: a classic organelle with new outfits, Histochemistry and Cell Biology, vol.1469, issue.2, pp.263-279, 2008.
DOI : 10.1007/s00418-008-0449-0

D. Kumar, G. Farrell, C. Fung, and J. George, Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response, Hepatology, vol.94, issue.5, pp.1266-1272, 2002.
DOI : 10.1053/jhep.2002.36370

A. Grassi, G. Ballardini, M. Susca, F. Bianchini, and S. Bonoli, HCV liver infection and liver steatosis: evidence for indirect mechanisms in genotype 3?, Alimentary Pharmacology and Therapeutics, vol.95, issue.s2, pp.79-82, 2005.
DOI : 10.1016/0270-9139(95)90525-1

E. Piver, P. Roingeard, and J. Pagès, The cell biology of hepatitis C virus (HCV) lipid addiction: Molecular mechanisms and its potential importance in the clinic, The International Journal of Biochemistry & Cell Biology, vol.42, issue.6, pp.869-879, 2010.
DOI : 10.1016/j.biocel.2010.01.005

K. Abid, V. Pazienza, A. De-gottardi, L. Rubbia-brandt, and B. Conne, An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation, Journal of Hepatology, vol.42, issue.5, pp.744-751, 2005.
DOI : 10.1016/j.jhep.2004.12.034

C. Jackel-cram, L. Babiuk, and Q. Liu, Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: Genotype-3a core has a stronger effect than genotype-1b core, Journal of Hepatology, vol.46, issue.6, pp.999-1008, 2007.
DOI : 10.1016/j.jhep.2006.10.019

G. Waris, D. Felmlee, F. Negro, and A. Siddiqui, Hepatitis C Virus Induces Proteolytic Cleavage of Sterol Regulatory Element Binding Proteins and Stimulates Their Phosphorylation via Oxidative Stress, Journal of Virology, vol.81, issue.15, pp.8122-8130, 2007.
DOI : 10.1128/JVI.00125-07

S. Clément, M. Peyrou, A. Sanchez-pareja, L. Bourgouin, and P. Ramadori, Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets, Hepatology, vol.100, issue.1, pp.38-49, 2011.
DOI : 10.1002/hep.24340

R. Jhaveri, G. Qiang, and A. Diehl, Domain 3 of Hepatitis C Virus Core Protein Is Sufficient for Intracellular Lipid Accumulation, The Journal of Infectious Diseases, vol.200, issue.11, pp.1781-1788, 2009.
DOI : 10.1086/648094

M. Ryan, P. Desmond, J. Slavin, and M. Congiu, Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver, Journal of Viral Hepatitis, vol.281, issue.1, pp.53-60, 2011.
DOI : 10.1111/j.1365-2893.2010.01283.x

T. Cai, J. Dufour, B. Muellhaupt, T. Gerlach, and M. Heim, Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis, Journal of Hepatology, vol.55, issue.3, pp.529-535, 2011.
DOI : 10.1016/j.jhep.2010.12.020

S. Sookoian, G. Castañ-o, A. Burgueñ-o, T. Gianotti, M. Rosselli et al., A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity, The Journal of Lipid Research, vol.50, issue.10, pp.2111-2116, 2009.
DOI : 10.1194/jlr.P900013-JLR200

S. Sookoian and C. Pirola, Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease, Hepatology, vol.25, issue.6, pp.1883-1894, 2011.
DOI : 10.1002/hep.24283

S. Mirandola, C. Osterreicher, M. Marcolongo, C. Datz, and E. Aigner, Microsomal triglyceride transfer protein polymorphism (???493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C, Liver International, vol.38, issue.4, pp.557-565, 2009.
DOI : 10.1111/j.1478-3231.2008.01892.x

R. Zampino, D. Ingrosso, E. Durante-mangoni, R. Capasso, and M. Tripodi, ) -493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients, Journal of Viral Hepatitis, vol.81, issue.5, pp.740-746, 2008.
DOI : 10.1111/j.1365-2893.2008.00994.x

J. Pawlotsky, L. Tsakiris, F. Roudot-thoraval, C. Pellet, and L. Stuyver, Relationship between Hepatitis C Virus Genotypes and Sources of Infection in Patients with Chronic Hepatitis C, Journal of Infectious Diseases, vol.171, issue.6, pp.1607-1610, 1995.
DOI : 10.1093/infdis/171.6.1607