Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells. - Archive ouverte HAL Access content directly
Journal Articles Critical Reviews in Immunology Year : 2012

Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells.

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Abstract

Plasmacytoid dendritic cells (pDCs) belong to the family of dendritic cells and possess specific features that distinguish them from conventional dendritic cells. For instance, pDC are the main interferon-alpha-secreting cells. Plasmacytoid dendritic cells exert both proinflammatory and regulatory functions. This is attested by the involvement of pDC through interferon-alpha secretion in several autoimmune diseases, and by the implication of pDC in tolerance. The same is true for TGF-β that plays a dual role in inflammation. In this review, we discuss recent data on pDC and TGF-β interactions. As with many cell types, pDCs are able to respond to TGF-β using the classic Smad signaling pathway. In addition, pDCs are capable to secrete TGF-β, in particular in response to TGF-β exposure. Exposure of pDCs to TGF-β prevents type I interferon secretion in response to TLR7/9 ligands. In contrast, the consequences of TGF-β on the antigen-presenting cell capacities of pDC are less clear, since TGF-β-exposed pDCs may lead to both regulatory T-cell and interleukin-17-secreting cell polarization. Here, we discuss the factors that may influence this polarization. We also discuss how pDCs exposed to TGF-β may participate in tolerance induction and maintenance, or, on the contrary, in autoimmune diseases.
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Dates and versions

inserm-00804423 , version 1 (25-03-2013)

Identifiers

  • HAL Id : inserm-00804423 , version 1
  • PUBMED : 23428227

Cite

Philippe Saas, Sylvain Perruche. Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells.. Critical Reviews in Immunology, 2012, 32 (6), pp.529-53. ⟨inserm-00804423⟩
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