Skip to Main content Skip to Navigation
Journal articles

Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.

Abstract : The purpose of this review is to outline our latest hypothesis on the mechanisms responsible for the genesis of paradoxical (REM) sleep (PS). On the basis of recent data, we propose that the onset and maintenance of PS are due to the activation by intrinsic and extrinsic factors of MCH/GABAergic neurons located in the lateral hypothalamic area. These neurons would inhibit during PS, GABAergic PS-off neurons located in the ventrolateral periaqueductal gray region. A number of results strongly suggest that these PS-off neurons gate the activation of the PS-on glutamatergic neurons located in the sublaterodorsal tegmental nucleus (SLD) and responsible for cortical activation and muscle atonia via descending projections to GABA/glycinergic neurons localized in the ventral medullary reticular nuclei.
Document type :
Journal articles
Complete list of metadata

Cited literature [57 references]  Display  Hide  Download
Contributor : Pierre-Hervé Luppi Connect in order to contact the contributor
Submitted on : Friday, March 22, 2013 - 10:27:56 AM
Last modification on : Saturday, September 24, 2022 - 3:04:06 PM
Long-term archiving on: : Sunday, April 2, 2017 - 6:24:02 PM


Files produced by the author(s)



Luppi Pierre-Hervé, Olivier Clément, Patrice Fort. Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.. Current Opinion in Neurobiology, Elsevier, 2013, epub ahead of print. ⟨10.1016/j.conb.2013.02.006⟩. ⟨inserm-00803493⟩



Record views


Files downloads