R. Fonseca, P. Bergsagel, J. Drach, J. Shaughnessy, and N. Gutierrez, International Myeloma Working Group molecular classification of multiple myeloma: spotlight review, Leukemia, vol.91, issue.12, pp.2210-2221, 2009.
DOI : 10.1016/j.beha.2007.08.004

B. Walker, P. Leone, L. Chiecchio, N. Dickens, and M. Jenner, A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value, Blood, vol.116, issue.15, pp.56-65, 2010.
DOI : 10.1182/blood-2010-04-279596

J. Shaughnessy, J. Zhan, F. Burington, B. Huang, Y. Colla et al., A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1, Blood, vol.109, issue.6, pp.2276-2284, 2007.
DOI : 10.1182/blood-2006-07-038430

O. Decaux, L. Lode, F. Magrangeas, C. Charbonnel, and W. Gouraud, Prediction of Survival in Multiple Myeloma Based on Gene Expression Profiles Reveals Cell Cycle and Chromosomal Instability Signatures in High-Risk Patients and Hyperdiploid Signatures in Low-Risk Patients: A Study of the Intergroupe Francophone du My??lome, Journal of Clinical Oncology, vol.26, issue.29, pp.4798-4805, 2008.
DOI : 10.1200/JCO.2007.13.8545

D. Hose, T. Reme, T. Hielscher, J. Moreaux, and T. Meissner, Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma, Haematologica, vol.96, issue.1, pp.87-95, 2011.
DOI : 10.3324/haematol.2010.030296

D. Hose, T. Reme, T. Meissner, J. Moreaux, and A. Seckinger, Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma, Blood, vol.113, issue.18, pp.4331-4340, 2009.
DOI : 10.1182/blood-2008-09-178350
URL : https://hal.archives-ouvertes.fr/inserm-00368414

W. Matsui, C. Huff, Q. Wang, M. Malehorn, and J. Barber, Characterization of clonogenic multiple myeloma cells, Blood, vol.103, issue.6, pp.2332-2336, 2004.
DOI : 10.1182/blood-2003-09-3064

D. Chiron, S. Surget, S. Maiga, R. Bataille, and P. Moreau, The peripheral CD138+ population but not the CD138??? population contains myeloma clonogenic cells in plasma cell leukaemia patients, British Journal of Haematology, vol.95, issue.5, pp.679-683, 2012.
DOI : 10.1111/j.1365-2141.2011.08904.x

K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, and T. Ichisaka, Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, issue.5, pp.861-872, 2007.
DOI : 10.1016/j.cell.2007.11.019

E. Lonardo, P. Hermann, M. Mueller, S. Huber, and A. Balic, Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy, Cell Stem Cell, vol.9, issue.5, pp.433-446, 2011.
DOI : 10.1016/j.stem.2011.10.001

M. Schoenhals, A. Kassambara, J. Vos, D. Hose, and J. Moreaux, Embryonic stem cell markers expression in cancers, Biochemical and Biophysical Research Communications, vol.383, issue.2, pp.157-162, 2009.
DOI : 10.1016/j.bbrc.2009.02.156
URL : https://hal.archives-ouvertes.fr/inserm-00367054

M. Jourdan, A. Caraux, D. Vos, J. Fiol, G. Larroque et al., An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization, Blood, vol.114, issue.25, pp.5173-5181, 2009.
DOI : 10.1182/blood-2009-07-235960
URL : https://hal.archives-ouvertes.fr/inserm-00446133

M. Jourdan, A. Caraux, G. Caron, N. Robert, and G. Fiol, Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation, The Journal of Immunology, vol.187, issue.8, pp.3931-3941, 2011.
DOI : 10.4049/jimmunol.1101230
URL : https://hal.archives-ouvertes.fr/hal-00743965

W. Matsui, Q. Wang, J. Barber, S. Brennan, and B. Smith, Clonogenic Multiple Myeloma Progenitors, Stem Cell Properties, and Drug Resistance, Cancer Research, vol.68, issue.1, pp.190-197, 2008.
DOI : 10.1158/0008-5472.CAN-07-3096

J. Jakubikova, S. Adamia, M. Kost-alimova, S. Klippel, and D. Cervi, Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications, Blood, vol.117, issue.17, pp.4409-4419, 2011.
DOI : 10.1182/blood-2010-02-267344

A. Sprynski, D. Hose, L. Caillot, T. Reme, J. Shaughnessy et al., The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor, Blood, vol.113, issue.19, pp.4614-4626, 2009.
DOI : 10.1182/blood-2008-07-170464
URL : https://hal.archives-ouvertes.fr/inserm-00367812

A. Seckinger, T. Meissner, J. Moreaux, H. Goldschmidt, and G. Fuhler, Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis, Oncogene, vol.83, issue.44, pp.3866-3879, 2009.
DOI : 10.1182/blood.V99.5.1745
URL : https://hal.archives-ouvertes.fr/inserm-00437705

T. Holien, T. Vatsveen, H. Hella, C. Rampa, and G. Brede, Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smaddependent repression of MYC, Leukemia, 2011.

J. Legg, J. Herbert, P. Clissold, and R. Bicknell, Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration, Angiogenesis, vol.30, issue.1, pp.13-21, 2008.
DOI : 10.1007/s10456-008-9100-x

K. Brose, K. Bland, K. Wang, D. Arnott, and W. Henzel, Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance, Cell, vol.96, issue.6, pp.795-806, 1999.
DOI : 10.1016/S0092-8674(00)80590-5

B. Wang, Y. Xiao, B. Ding, N. Zhang, and X. Yuan, Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity, Cancer Cell, vol.4, issue.1, pp.19-29, 2003.
DOI : 10.1016/S1535-6108(03)00164-8

B. Schmid, G. Rezniczek, G. Fabjani, T. Yoneda, and S. Leodolter, The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells, Breast Cancer Research and Treatment, vol.63, issue.5, pp.333-342, 2007.
DOI : 10.1007/s10549-007-9504-0

K. Mahtouk, . Cf, T. Rème, J. M. Baudard, M. Moreaux et al., Heparan sulphate proteoglycans are essential for the myeloma cell growth activity of EGF-family ligands in multiple myeloma, Oncogene, vol.83, issue.54, pp.7180-7191, 2006.
DOI : 10.1038/sj.onc.1209699
URL : https://hal.archives-ouvertes.fr/inserm-00128880

I. Wessler, C. Kirkpatrick, and K. Racke, THE CHOLINERGIC 'PITFALL': ACETYLCHOLINE, A UNIVERSAL CELL MOLECULE IN BIOLOGICAL SYSTEMS, INCLUDING HUMANS, Clinical and Experimental Pharmacology and Physiology, vol.58, issue.3, pp.198-205, 1999.
DOI : 10.1016/0006-2952(76)90473-1

I. Wessler, H. Kilbinger, F. Bittinger, and C. Kirkpatrick, The Biological Role of Non-neuronal Acetylcholine in Plants and Humans., The Japanese Journal of Pharmacology, vol.85, issue.1, pp.2-10, 2001.
DOI : 10.1254/jjp.85.2

L. Sperling, G. Steinert, J. Boutter, D. Landgraf, and J. Hescheler, Characterisation of cholinesterase expression during murine embryonic stem cell differentiation, Chemico-Biological Interactions, vol.175, issue.1-3, pp.156-160, 2008.
DOI : 10.1016/j.cbi.2008.05.034

L. Paraoanu, G. Steinert, A. Koehler, I. Wessler, and P. Layer, Expression and possible functions of the cholinergic system in a murine embryonic stem cell line, Life Sciences, vol.80, issue.24-25, pp.2375-2379, 2007.
DOI : 10.1016/j.lfs.2007.03.008

P. Szymanski, A. Janik, E. Zurek, and E. Mikiciuk-olasik, ChemInform Abstract: Design, Synthesis and Biological Evaluation of New 2-Benzoxazolinone Derivatives as Potential Cholinesterase Inhibitors for Therapy of Alzheimer???s Disease., ChemInform, vol.66, issue.34, pp.399-403, 2011.
DOI : 10.1002/chin.201134123

G. Bjerke, C. Hyman-walsh, and D. Wotton, Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1, Molecular and Cellular Biology, vol.31, issue.18, pp.3723-3733, 2011.
DOI : 10.1128/MCB.01456-10

K. Barber, C. Harrison, Z. Broadfield, A. Stewart, and S. Wright, Molecular cytogenetic characterization ofTCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia, Genes, Chromosomes and Cancer, vol.79, issue.5, pp.478-486, 2007.
DOI : 10.1002/gcc.20431

K. Chan, J. Zhang, N. Chia, Y. Chan, and H. Sim, Expression in Human Embryonic Stem Cells, Stem Cells, vol.3, issue.9, pp.2114-2125, 2009.
DOI : 10.1002/stem.143

J. Jaruzelska, M. Kotecki, K. Kusz, A. Spik, and M. Firpo, Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells, Dev Genes Evol, vol.213, pp.120-126, 2003.

Z. Wang and H. Lin, Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation, Science, vol.303, issue.5666, pp.2016-2019, 2004.
DOI : 10.1126/science.1093983

S. Rickelt, S. Winter-simanowski, E. Noffz, C. Kuhn, and W. Franke, Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells, International Journal of Cancer, vol.165, issue.9, pp.2036-2048, 2009.
DOI : 10.1002/ijc.24552

R. Groen, M. De-rooij, K. Kocemba, R. Reijmers, and A. De-haan-kramer, N-cadherin-mediated adhesion of multiple myeloma cells inhibits osteoblast differentiation, Haematologica, 2011.

J. Moreaux, F. Cremer, T. Reme, M. Raab, and K. Mahtouk, The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature, Blood, vol.106, issue.3, pp.1021-1030, 2005.
DOI : 10.1182/blood-2004-11-4512
URL : https://hal.archives-ouvertes.fr/inserm-00129406

J. Moreaux, D. Hose, A. Kassambara, T. Reme, and P. Moine, Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration, Blood, vol.117, issue.4, pp.1280-1290, 2011.
DOI : 10.1182/blood-2010-04-279760
URL : https://hal.archives-ouvertes.fr/inserm-00906774

J. Corre, K. Mahtouk, M. Attal, M. Gadelorge, and A. Huynh, Bone marrow mesenchymal stem cells are abnormal in multiple myeloma, Leukemia, vol.63, pp.1079-1088, 2007.
DOI : 10.1038/sj.leu.2404621
URL : https://hal.archives-ouvertes.fr/inserm-00270565

X. Zhang, J. Gaillard, N. Robillard, Z. Lu, and Z. Gu, Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma, Blood, vol.83, pp.3654-3663, 1994.

C. Rebouissou, J. Wijdenes, P. Autissier, K. Tarte, and V. Costes, A gp130 Interleukin-6 Transducer-Dependent SCID Model of Human Multiple Myeloma, Blood, vol.91, pp.4727-4737, 1998.

Z. Gu, J. Vos, C. Rebouissou, J. M. Zhang, and X. , Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors, Leukemia, vol.14, issue.1, pp.188-197, 2000.
DOI : 10.1038/sj.leu.2401632

J. Moreaux, B. Klein, R. Bataille, G. Descamps, and S. Maiga, A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines, Haematologica, vol.96, issue.4, pp.574-582, 2011.
DOI : 10.3324/haematol.2010.033456
URL : https://hal.archives-ouvertes.fr/inserm-00550232

B. Barlogie, G. Tricot, E. Rasmussen, E. Anaissie, and F. Van-rhee, Total therapy 2 without thalidomide in comparison with total therapy 1: role of intensified induction and posttransplantation consolidation therapies, Blood, vol.107, issue.7, pp.2633-2638, 2006.
DOI : 10.1182/blood-2005-10-4084

F. Cremer, J. Bila, I. Buck, M. Kartal, and D. Hose, Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics, Genes, Chromosomes and Cancer, vol.40, issue.2, pp.194-203, 2005.
DOI : 10.1002/gcc.20231

W. Xiong, X. Wu, S. Starnes, S. Johnson, and J. Haessler, An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma, Blood, vol.112, issue.10, pp.4235-4246, 2008.
DOI : 10.1182/blood-2007-10-119123

T. Reme, D. Hose, D. Vos, J. Vassal, A. Poulain et al., A new method for class prediction based on signed-rank algorithms applied to Affymetrix?? microarray experiments, BMC Bioinformatics, vol.9, issue.1, p.16, 2008.
DOI : 10.1186/1471-2105-9-16
URL : https://hal.archives-ouvertes.fr/inserm-00268075

T. Le-carrour, S. , S. Tondeur, L. Lhermitte, N. Lamb et al., Amazonia!: An Online Resource to Google and Visualize Public Human whole Genome Expression Data, The Open Bioinformatics Journal, vol.4, issue.1, pp.5-10, 2010.
DOI : 10.2174/1875036201004010005

R. Team, R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing, 2008.

R. Gentleman, V. Carey, D. Bates, B. Bolstad, and M. Dettling, Bioconductor: open software development for computational biology and bioinformatics, Genome Biology, vol.5, issue.10, p.80, 2004.
DOI : 10.1186/gb-2004-5-10-r80