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Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside.

Abstract : Gamma delta (γδ) Τ cells are non-conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that these T cells, which are implicated in the first line of defence against pathogens, have anti-tumour activity against many cancers and suggest that γδ Τ cell-mediated immunotherapy is feasible and might induce objective tumour responses. Due to the importance of γδ Τ lymphocytes in the induction and control of immunity, a complete understanding of their biology is crucial for the development of a potent cancer immunotherapy. This review discusses recent advances in γδ Τ basic research and data from clinical trials on the use of γδ Τ cells in the treatment of different cancers. It analyses how this knowledge might be applied to develop new strategies for the clinical manipulation and the potentiation of γδ Τ lymphocyte activity in cancer immunotherapy.
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https://www.hal.inserm.fr/inserm-00802672
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Submitted on : Wednesday, March 20, 2013 - 11:39:41 AM
Last modification on : Friday, May 15, 2020 - 12:22:03 PM
Long-term archiving on: : Sunday, April 2, 2017 - 3:38:15 PM

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Mounia Braza, Bernard Klein. Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside.. British Journal of Haematology, Wiley, 2013, 160 (2), pp.123-32. ⟨10.1111/bjh.12090⟩. ⟨inserm-00802672⟩

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