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Journal articles
Residual malignant and normal plasma cells shortly after high dose melphalan and stem cell transplantation. Highlight of a putative therapeutic window in Multiple Myeloma?
Abstract : Multiple Myeloma (MM) is an incurable malignant plasma cell disorder. We have evaluated the counts of Multiple Myeloma Cells (MMCs) and normal plasma cells (N-PCs), seven days after high-dose melphalan (HDM) and autologous stem transplantation (ASCT). Two third of patients had detectable minimal residual disease (MRD+) (71.7 MMCs/µL) after induction treatment with dexamethasone and proteasome inhibitor. MMC counts were reduced by 92% (P ≤ .05) but not eradicated 7 days after HDM+ASCT. Post-HDM+ASCT MMCs were viable and bathed in a burst of MMC growth factors, linked with post-HDM aplasia. In one third of patients (MRD- patients), MMCs were not detectable after induction treatment and remained undetectable after HDM+ASCT. Major difference between MRD- and MRD+ patients is that N-PC counts were increased 3 fold (P〈.05) by HDM+ASCT in MRD- patients, but were unaffected in MRD+ patients. Possible explanation could be that clearance of MMCs in MRD- patients makes more niches available for N-PCs. Thus, MMCs are not fully eradicated shortly after HDM, are bathed in high concentrations of MMC growth factors in an almost desert BM, are viable in short-term culture, which suggests providing additional therapies shortly after HDM to kill resistant MMCs before full repair of lesions.
Cited literature [12 references]
https://www.hal.inserm.fr/inserm-00802665
Contributor : Monique Frei <>
Submitted on : Wednesday, March 20, 2013 - 11:30:38 AM
Last modification on : Friday, May 15, 2020 - 12:22:05 PM
Long-term archiving on: : Friday, June 21, 2013 - 4:13:42 AM
Contributor : Monique Frei <>
Submitted on : Wednesday, March 20, 2013 - 11:30:38 AM
Last modification on : Friday, May 15, 2020 - 12:22:05 PM
Long-term archiving on: : Friday, June 21, 2013 - 4:13:42 AM
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