Skip to Main content Skip to Navigation
Journal articles

Severe neonatal hypercalcemia caused by subcutaneous fat necrosis without any apparent cutaneous lesion.

Abstract : Subcutaneous fat necrosis is a classic, albeit uncommon, cause of neonatal hypercalcemia. It occurs in newborn infants within the first month of life following a complicated delivery. The diagnosis is usually easy because of the presence of red-purple plaques in fatty areas along with firm subcutaneous nodules. A 1-month-old neonate, born strangled by her umbilical cord, presented with diarrhea and hypercalcemia (3.46 mM) with an initial physical examination considered normal. Her biological evaluations were as follows: P = 1.37 mM (1.6-2.2); PTH = 3 ng/L (12-65); 25-OH vitamin D = 87 nM (23-113); (1,25)-OH(2) vitamin D = 192 ng/L (20-46). The third day, a careful exam of the whole cutaneous surface revealed small firm subcutaneous nodules in the ischial region. Despite the absence of any visible skin modification, the association of perinatal stress and high (1,25)-OH(2) vitamin D level with subcutaneous nodules led to the diagnosis of subcutaneous fat necrosis. She was treated with oral prednisone for 45 days. Serum calcium levels normalized within a week, and the nodules disappeared without complications. Conclusion: Subcutaneous fat necrosis may induce severe hypercalcemia without any visible cutaneous lesion.
Document type :
Journal articles
Complete list of metadatas

Cited literature [14 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00800392
Contributor : Laurent Bonnemains <>
Submitted on : Wednesday, March 13, 2013 - 4:09:16 PM
Last modification on : Wednesday, December 19, 2018 - 3:02:07 PM
Long-term archiving on: : Sunday, April 2, 2017 - 12:38:03 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Laurent Bonnemains, Stephanie Rouleau, Gaelle Sing, Claude Bouderlique, Regis Coutant. Severe neonatal hypercalcemia caused by subcutaneous fat necrosis without any apparent cutaneous lesion.. European Journal of Pediatrics, Springer Verlag, 2008, 167 (12), pp.1459-61. ⟨10.1007/s00431-008-0682-5⟩. ⟨inserm-00800392⟩

Share

Metrics

Record views

868