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CMV and Immunosenescence: from basics to clinics.

Rafael Solana 1, * Raquel Tarazona 2 Allison Aiello 3 Arne Akbar 4 Victor Appay 5 Mark Beswick 6 Jos Bosch 7, 8 Carmen Campos 1 Sara Cantisán 1 Luka Cicin-Sain 9 Evelyna Derhovanessian 10 Sara Ferrando-Martínez 11 Daniela Frasca 12 Tamas Fulöp 13 Sheila Govind 14 Beatrix Grubeck-Loebenstein 15 Ann Hill 16 Mikko Hurme 17 Florian Kern 18 Anis Larbi 19 Miguel López-Botet 20 Andrea Maier 21 Janet Mcelhaney 22 Paul Moss 6 Elissaveta Naumova 23 Janko Nikolich-Zugich 24 Alejandra Pera 1 Jerrald Rector 25 Natalie Riddell 4 Beatriz Sanchez-Correa 2 Paolo Sansoni 26 Delphine Sauce 5 Rene van Lier 27 George Wang 28 Mark Wills 29 Maciej Zieliński 30 Graham Pawelec 10
Abstract : Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
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Rafael Solana, Raquel Tarazona, Allison Aiello, Arne Akbar, Victor Appay, et al.. CMV and Immunosenescence: from basics to clinics.. Immunity & Ageing, 2012, 9 (1), pp.23. ⟨10.1186/1742-4933-9-23⟩. ⟨inserm-00796144⟩

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