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Journal Articles Immunity & Ageing Year : 2012

CMV and Immunosenescence: from basics to clinics.

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Rafael Solana
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  • PersonId : 914401

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Raquel Tarazona
  • Function : Author
  • PersonId : 937546
Allison Aiello
  • Function : Author
  • PersonId : 937547
Arne Akbar
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  • PersonId : 914373
Victor Appay
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  • PersonId : 871208
Mark Beswick
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  • PersonId : 937548
Carmen Campos
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Sara Cantisán
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  • PersonId : 937550
Evelyna Derhovanessian
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  • PersonId : 937552
Daniela Frasca
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  • PersonId : 937554
Sheila Govind
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  • PersonId : 937556
Mikko Hurme
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  • PersonId : 907681
Florian Kern
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  • PersonId : 914386
Anis Larbi
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  • PersonId : 937558
Andrea Maier
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  • PersonId : 914390
Janet Mcelhaney
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  • PersonId : 937560
Paul Moss
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Elissaveta Naumova
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  • PersonId : 937561
Janko Nikolich-Zugich
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Alejandra Pera
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  • PersonId : 937562
Jerrald Rector
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Natalie Riddell
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  • PersonId : 914397
Beatriz Sanchez-Correa
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  • PersonId : 937564
Delphine Sauce
Rene van Lier
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  • PersonId : 914404
George Wang
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  • PersonId : 914406
Mark Wills
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  • PersonId : 937565
Graham Pawelec
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  • PersonId : 914407

Abstract

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop.
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inserm-00796144 , version 1 (01-03-2013)

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Rafael Solana, Raquel Tarazona, Allison Aiello, Arne Akbar, Victor Appay, et al.. CMV and Immunosenescence: from basics to clinics.. Immunity & Ageing, 2012, 9 (1), pp.23. ⟨10.1186/1742-4933-9-23⟩. ⟨inserm-00796144⟩
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