G. Fritz, I. Just, and B. Kaina, Rho GTPases are over-expressed in human tumors, International Journal of Cancer, vol.271, issue.5, pp.682-687, 1999.
DOI : 10.1002/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B

A. Bellizzi, A. Mangia, A. Chiriatti, S. Petroni, M. Quaranta et al., RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease, International Journal of Molecular Medicine, vol.22, issue.1, pp.25-31, 2008.
DOI : 10.3892/ijmm.22.1.25

X. Li, J. F. Ouyang, J. Wu, W. Qian, L. Yang et al., Overexpression of RhoA is associated with poor prognosis in hepatocellular carcinoma, European Journal of Surgical Oncology (EJSO), vol.32, issue.10, pp.1130-1134, 2006.
DOI : 10.1016/j.ejso.2006.05.012

G. Del-pulgar, T. Benitah, S. Valeron, P. Espina, C. Lacal et al., Rho GTPase expression in tumourigenesis: Evidence for a significant link, BioEssays, vol.62, issue.6, pp.602-613, 2005.
DOI : 10.1002/bies.20238

C. Nobes and A. Hall, Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, vol.81, issue.1, pp.53-62, 1995.
DOI : 10.1016/0092-8674(95)90370-4

K. Rottner, A. Hall, and J. Small, Interplay between Rac and Rho in the control of substrate contact dynamics, Current Biology, vol.9, issue.12, pp.640-648, 1999.
DOI : 10.1016/S0960-9822(99)80286-3

E. Sander, J. Klooster, S. Van-delft, R. Van-der-kammen, and J. Collard, Rac Downregulates Rho Activity, The Journal of Cell Biology, vol.11, issue.5, pp.1009-1022, 1999.
DOI : 10.1091/mbc.8.11.2329

L. Haataja, J. Groffen, and N. Heisterkamp, Characterization of RAC3, a Novel Member of the Rho Family, Journal of Biological Chemistry, vol.272, issue.33, pp.20384-20388, 1997.
DOI : 10.1074/jbc.272.33.20384

M. Chou and J. Blenis, The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1, Cell, vol.85, issue.4, pp.573-583, 1996.
DOI : 10.1016/S0092-8674(00)81257-X

P. Baugher, L. Krishnamoorthy, J. Price, and S. Dharmawardhane, Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells, Breast Cancer Research, vol.7, issue.6, pp.965-974, 2005.
DOI : 10.1186/bcr1329

A. Karnoub, D. Worthylake, K. Rossman, W. Pruitt, S. Campbell et al., Molecular basis for Rac1 recognition by guanine nucleotide exchange factors, Nature Structural Biology, vol.8, issue.12, pp.1037-1041, 2001.
DOI : 10.1038/nsb719

Y. Cho, B. Zhang, V. Kaartinen, L. Haataja, I. De-curtis et al., Generation of rac3 Null Mutant Mice: Role of Rac3 in Bcr/Abl-Caused Lymphoblastic Leukemia, Molecular and Cellular Biology, vol.25, issue.13, pp.255777-5785, 2005.
DOI : 10.1128/MCB.25.13.5777-5785.2005

K. Leung, A. Nagy, I. Gonzalez-gomez, J. Groffen, N. Heisterkamp et al., Targeted Expression of Activated Rac3 in Mammary Epithelium Leads to Defective Postlactational Involution and Benign Mammary Gland Lesions, Cells Tissues Organs, vol.175, issue.2, pp.72-83, 2003.
DOI : 10.1159/000073751

S. Hwang, J. Chang, T. Cheng, W. Sy, A. Lieu et al., Expression of Rac3 in human brain tumors, Journal of Clinical Neuroscience, vol.12, issue.5, pp.571-574, 2005.
DOI : 10.1016/j.jocn.2004.08.013

T. Tuschl, Expanding small RNA interference, Nature Biotechnology, vol.20, issue.5, pp.446-448, 2002.
DOI : 10.1038/nbt0502-446

URL : http://hdl.handle.net/11858/00-001M-0000-0012-F3CE-4

Y. Pan, F. Bi, N. Liu, Y. Xue, X. Yao et al., Expression of seven main Rho family members in gastric carcinoma, Biochemical and Biophysical Research Communications, vol.315, issue.3, pp.315686-691, 2004.
DOI : 10.1016/j.bbrc.2004.01.108

M. Cominetti, A. Martin, J. Ribeiro, I. Djaafri, F. Fauvel-lafeve et al., Selistre-de-Araujo HS: Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions, Biochimie, issue.8, pp.911045-1052, 2009.

E. Monnet, P. Sizaret, and B. Arbeille, Fauvel-Lafeve F: Different role of platelet glycoprotein GP Ia/IIa in platelet contact and activation induced by type I and type III collagens, Thromb Res, issue.5, pp.98423-433, 2000.

M. Mekrache, P. Legendre, N. Kieffer, and D. Baruch, Activation of integrin alphaIIbbeta3 expressed in Chinese hamster ovary cells is required for interaction with solid-phase von Willebrand factor, British Journal of Haematology, vol.269, issue.4, pp.1024-1032, 2002.
DOI : 10.1074/jbc.274.51.36241

N. Garamszegi, S. Garamszegi, L. Shehadeh, and S. Scully, Extracellular Matrix-Induced Gene Expression in Human Breast Cancer Cells, Molecular Cancer Research, vol.7, issue.3, pp.319-329, 2009.
DOI : 10.1158/1541-7786.MCR-08-0227

V. Zohrabian, H. Nandu, N. Gulati, G. Khitrov, C. Zhao et al., Gene expression profiling of metastatic brain cancer, Oncology Reports, vol.18, issue.2, pp.321-328, 2007.
DOI : 10.3892/or.18.2.321

S. Zhang, D. Zhang, and B. Sun, Vasculogenic mimicry: Current status and future prospects, Cancer Letters, vol.254, issue.2, pp.157-164, 2007.
DOI : 10.1016/j.canlet.2006.12.036

J. Pille, C. Denoyelle, J. Varet, J. Bertrand, J. Soria et al., Anti-RhoA and Anti-RhoC siRNAs Inhibit the Proliferation and Invasiveness of MDA-MB-231 Breast Cancer Cells in Vitro and in Vivo, Molecular Therapy, vol.11, issue.2, pp.267-274, 2005.
DOI : 10.1016/j.ymthe.2004.08.029

J. Mira, V. Benard, J. Groffen, L. Sanders, and U. Knaus, Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway, Proceedings of the National Academy of Sciences, vol.97, issue.1, pp.185-189, 2000.
DOI : 10.1073/pnas.97.1.185

A. Chan, S. Coniglio, Y. Chuang, D. Michaelson, U. Knaus et al., Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion, Oncogene, vol.276, issue.53, pp.7821-7829, 2005.
DOI : 10.1016/S0968-0004(01)01973-9

A. Hajdo-milasinovic, S. Ellenbroek, S. Van-es, B. Van-der-vaart, and J. Collard, Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells, Journal of Cell Science, vol.120, issue.4, pp.555-566, 2007.
DOI : 10.1242/jcs.03364

P. Joyce and A. Cox, Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling, Cancer Res, vol.63, issue.22, pp.7959-7967, 2003.

R. Rathinam and S. Alahari, Important role of integrins in the cancer biology, Cancer and Metastasis Reviews, vol.68, issue.Suppl 2, pp.223-237
DOI : 10.1007/s10555-010-9211-x

I. Pecheur, O. Peyruchaud, C. Serre, J. Guglielmi, C. Voland et al., Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone, FASEB J, issue.10, pp.161266-1268, 2002.

L. Clainche, C. Carlier, and M. , Regulation of Actin Assembly Associated With Protrusion and Adhesion in Cell Migration, Physiological Reviews, vol.88, issue.2, pp.489-513, 2008.
DOI : 10.1152/physrev.00021.2007

M. Sheetz, D. Felsenfeld, and C. Galbraith, Cell migration: regulation of force on extracellular-matrix-integrin complexes, Trends in Cell Biology, vol.8, issue.2, pp.51-54, 1998.
DOI : 10.1016/S0962-8924(98)80005-6

R. Folberg and A. Maniotis, Vasculogenic mimicry, APMIS, vol.52, issue.suppl, pp.508-525, 2004.
DOI : 10.1111/j.1600-0463.2004.apm11207-0810.x

B. Sun, S. Qie, S. Zhang, T. Sun, X. Zhao et al., Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumors, Human Pathology, vol.39, issue.3, pp.444-451, 2008.
DOI : 10.1016/j.humpath.2007.07.018

F. Lee, J. Hagler, Z. Chen, and T. Maniatis, Activation of the I??B?? Kinase Complex by MEKK1, a Kinase of the JNK Pathway, Cell, vol.88, issue.2, pp.213-222, 1997.
DOI : 10.1016/S0092-8674(00)81842-5

M. Karin and Y. Ben-neriah, Phosphorylation Meets Ubiquitination: The Control of NF-??B Activity, Annual Review of Immunology, vol.18, issue.1, pp.621-663, 2000.
DOI : 10.1146/annurev.immunol.18.1.621

H. Ling, H. Yang, S. Tan, W. Chui, and E. Chew, 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factorkappaB activation, Br J Pharmacol, issue.8, pp.1611763-1777, 2010.

P. Vayalil and S. Katiyar, Treatment of epigallocatechin-3-gallate inhibits matrix metalloproteinases-2 and -9 via inhibition of activation of mitogen-activated protein kinases, c-jun and NF-?B in human prostate carcinoma DU-145 cells, The Prostate, vol.284, issue.1, pp.33-42, 2004.
DOI : 10.1002/pros.10352

S. Gupta, H. Su, R. Bi, S. Agrawal, and S. Gollapudi, Life and death of lymphocytes: a role in immunesenescence. Immunity & ageing: I & A, p.12, 2005.

T. Kishimoto, The biology of interleukin-6, Blood, vol.74, issue.1, pp.1-10, 1989.

H. Yssel, D. Waal, M. Roncarolo, M. Abrams, J. Lahesmaa et al., IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells, J Immunol, issue.7, pp.1492378-2384, 1992.

L. Kozlowski, I. Zakrzewska, P. Tokajuk, and M. Wojtukiewicz, Concentration of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-10 (IL-10) in blood serum of breast cancer patients, Rocz Akad Med Bialymst, vol.48, pp.82-84, 2003.

S. Youngs, S. Ali, D. Taub, and R. Rees, Chemokines induce migrational responses in human breast carcinoma cell lines, International Journal of Cancer, vol.360, issue.2, pp.257-266, 1997.
DOI : 10.1002/(SICI)1097-0215(19970410)71:2<257::AID-IJC22>3.0.CO;2-D

P. Barnes and K. M. , Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases, N Engl J Med, vol.336, issue.15, pp.1066-1071, 1997.

K. Amiri and R. A. , Fine Tuning the Transcriptional Regulation of the CXCL1 Chemokine, Prog Nucleic Acid Res Mol Biol, vol.74, pp.1-36, 2003.
DOI : 10.1016/S0079-6603(03)01009-2

R. Fernando, M. Castillo, M. Litzinger, D. Hamilton, and C. Palena, IL-8 Signaling Plays a Critical Role in the Epithelial-Mesenchymal Transition of Human Carcinoma Cells, Cancer Research, vol.71, issue.15, pp.715296-5306, 2011.
DOI : 10.1158/0008-5472.CAN-11-0156

S. Patel, S. Vetale, P. Teli, R. Mistry, and S. Chiplunkar, IL-10 production in nonsmall cell lung carcinoma patients is regulated by ERK, P38 and COX-2, J Cell Mol Med, 2011.

T. Takenawa and H. Miki, WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement, J Cell Sci, vol.114, pp.1801-1809, 2001.

. Gest, Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines, BMC Cancer, vol.114, issue.Pt 10, p.63, 2013.
DOI : 10.1158/0008-5472.CAN-11-0156

URL : https://hal.archives-ouvertes.fr/inserm-00790736