N. Gajraj, Pregabalin: Its pharmacology and use in pain management, Acute Pain, vol.10, issue.1, pp.1805-1820, 2007.
DOI : 10.1016/j.acpain.2008.01.030

C. Taylor, Mechanisms of analgesia by gabapentin and pregabalin ??? Calcium channel ??2-?? [Cav??2-??] ligands, Pain, vol.142, issue.1, pp.13-19, 2009.
DOI : 10.1016/j.pain.2008.11.019

F. Besag and D. Berry, Interactions between Antiepileptic and Antipsychotic Drugs, Drug Safety, vol.28, issue.3, pp.95-118, 2006.
DOI : 10.2165/00002018-200629020-00001

A. Buvanendran, J. Kroin, D. Valle, and C. , Perioperative Oral Pregabalin Reduces Chronic Pain After Total Knee Arthroplasty: A Prospective, Randomized, Controlled Trial, Anesthesia & Analgesia, vol.110, issue.1, pp.199-207, 2010.
DOI : 10.1213/ANE.0b013e3181c4273a

R. Seib and J. Paul, ??administration pr??op??ratoire de gabapentine pour ??analg??sie postop??ratoire: une m??ta-analyse, Canadian Journal of Anesthesia/Journal canadien d'anesth??sie, vol.88, issue.5, pp.461-470, 2006.
DOI : 10.1007/BF03022618

K. Ho, T. Gan, and A. Habib, Gabapentin and postoperative pain: a systematic review of randomized controlled trials, Pain, vol.126, pp.1-391, 2006.

R. Hurley, S. Cohen, and K. Williams, The Analgesic Effects of Perioperative Gabapentin on Postoperative Pain, Regional Anesthesia and Pain Medicine, vol.31, issue.3, pp.237-284, 2006.
DOI : 10.1097/00115550-200605000-00011

P. Wiffen, S. Collins, and H. Mcquay, Anticonvulsant drugs for acute and chronic pain, Cochrane Database Syst Rev, issue.3, p.1133, 2005.

R. Moore, S. Straube, and P. Wiffen, Pregabalin for acute and chronic pain in adults, Cochrane Database Syst Rev, vol.17, issue.5, p.7076, 2009.
DOI : 10.1002/14651858.CD007076.pub2

G. Zaccara, P. Gangemi, and P. Perucca, The adverse event profile of pregabalin: A systematic review and meta-analysis of randomized controlled trials, Epilepsia, vol.15, issue.suppl 6, pp.826-862, 2011.
DOI : 10.1111/j.1528-1167.2010.02966.x

D. Khurana, J. Riviello, and S. Helmers, Efficacy of gabapentin therapy in children with refractory partial seizures, The Journal of Pediatrics, vol.128, issue.6, pp.829-862, 1996.
DOI : 10.1016/S0022-3476(96)70336-0

R. Sabatowski, R. Galvez, and D. Cherry, Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial, Pain, vol.109, issue.1, pp.26-35, 2004.
DOI : 10.1016/j.pain.2004.01.001

I. Edwards and J. Aronson, Adverse drug reactions: definitions, diagnosis, and management, The Lancet, vol.356, issue.9237, pp.1255-1264, 2000.
DOI : 10.1016/S0140-6736(00)02799-9

J. Montastruc, A. Sommet, and I. Lacroix, Pharmacovigilance for??evaluating adverse drug reactions: value, organization, and??methods, Joint Bone Spine, vol.73, issue.6, pp.629-661, 2006.
DOI : 10.1016/j.jbspin.2006.09.002

G. Durrieu, P. Olivier, and H. Bagheri, Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database, Fundamental & Clinical Pharmacology, vol.26, issue.5, pp.555-563, 2007.
DOI : 10.1016/S0750-7658(02)00650-0

R. Fuzier, M. Lapeyre-mestre, and K. Samii, Adverse Drug Reactions to Local Anaesthetics, Drug Safety, vol.47, issue.3, pp.345-56, 2009.
DOI : 10.2165/00002018-200932040-00008

N. Tavassoli, M. Lapeyre-mestre, and A. Sommet, Reporting rate of adverse drug reactions to the French pharmacovigilance system with three step 2 analgesic drugs: dextropropoxyphene, tramadol and codeine (in combination with paracetamol), British Journal of Clinical Pharmacology, vol.47, issue.3, pp.422-428, 2009.
DOI : 10.1111/j.1365-2125.2009.03472.x

B. Begaud, J. Evreux, and J. Jouglard, Unexpected or toxic drug reaction assessment (imputation): actualization of the method used in France, Therapie, vol.40, pp.111-119, 1985.

D. Food and H. Administration, International Conference on Harmonisation; guidance on addendum to E2C clinical safety data management: periodic safety update reports for marketed drugs; availability, Notice. Fed Regist, vol.69, issue.24, pp.5551-5553, 2004.

W. The, . Centre-for-drug-statistics-methodology, . Atc, and . Ddd, Available from URL: http://www. whocc, 2010.

V. Bozikas, G. Garyfallos, and N. Nikolaidis, Pregabalin induced neutropenia, Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol.32, issue.3, pp.907-915, 2008.
DOI : 10.1016/j.pnpbp.2007.12.023

D. Bates, S. Kirby, and A. Louw, Thrombocytopenia possibly induced by pregabalin, Can J Hosp Pharm, vol.61, issue.6, pp.446-453, 2008.

R. Aster and D. Bougie, Drug-Induced Immune Thrombocytopenia, New England Journal of Medicine, vol.357, issue.6, pp.580-587, 2007.
DOI : 10.1056/NEJMra066469

C. Richardson, D. Williams, and J. Kingham, Drug points: Gabapentin induced cholestasis, BMJ, vol.325, issue.7365, p.635, 2002.
DOI : 10.1136/bmj.325.7365.635
URL : http://www.bmj.com/cgi/content/short/325/7365/635

C. Bureau, H. Poirson, and J. Peron, Gabapentine-induced acute hepatitis, Gastroenterol Clin Biol, vol.27, issue.12, pp.1169-70, 2003.

E. Perucca, Clinically relevant drug interactions with antiepileptic drugs, British Journal of Clinical Pharmacology, vol.204, issue.3, pp.246-55, 2006.
DOI : 10.2165/00002512-200320020-00005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885026

F. Thiessard, E. Roux, and G. Miremont-salame, Trends in Spontaneous Adverse Drug Reaction Reports to the French Pharmacovigilance System (1986???2001), Drug Safety, vol.46, issue.8, pp.731-771, 1986.
DOI : 10.2165/00002018-200528080-00007
URL : https://hal.archives-ouvertes.fr/hal-00396045

F. Rosa, Holoprosencephaly and antiepileptic exposures, Teratology, vol.51, issue.4, p.230, 1995.
DOI : 10.1002/tera.1420510405

G. Montouris, Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry, Epilepsy & Behavior, vol.4, issue.3, pp.310-317, 2003.
DOI : 10.1016/S1525-5050(03)00110-0

D. Molgaard-nielsen and A. Hviid, Newer-generation antiepileptic drugs and the risk of major birth defects, JAMA, vol.305, pp.1996-2002, 2011.

J. Morrow, A. Russell, and E. Guthrie, Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register, Journal of Neurology, Neurosurgery & Psychiatry, vol.77, issue.2, pp.193-201, 2006.
DOI : 10.1136/jnnp.2005.074203

J. Jentink, M. Loane, and H. Dolk, Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations, New England Journal of Medicine, vol.362, issue.23, pp.2185-93, 2010.
DOI : 10.1056/NEJMoa0907328

J. Jentink, H. Dolk, and M. Loane, Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study, BMJ, vol.341, issue.dec02 1, p.6581, 2010.
DOI : 10.1136/bmj.c6581

C. Harden, K. Meador, and P. Pennell, Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes, Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurology and the, pp.1237-1283, 2009.
DOI : 10.1111/j.1528-1167.2009.02129.x

J. Weber, Epidemiology of adverse reactions to non-steroidal antiinflammatory drugs Advances in inflammatory research, pp.1-7, 1984.

N. Hartnell and J. Wilson, Replication of the Weber Effect Using Postmarketing Adverse Event Reports Voluntarily Submitted to the United States Food and Drug Administration, Pharmacotherapy, vol.10, issue.6, pp.743-752, 2004.
DOI : 10.1038/clpt.1989.206

P. Wiffen, H. Mcquay, and J. Edwards, Gabapentin for acute and chronic pain, Cochrane Database Syst Rev, vol.311, issue.3, p.5452, 2005.
DOI : 10.1002/14651858.CD005452.pub2

J. Fischer, A. Barr, and S. Rogers, Lack of serious toxicity following gabapentin overdose, Neurology, vol.44, issue.5, pp.982-985, 1994.
DOI : 10.1212/WNL.44.5.982

H. Spiller, R. Bratcher, and J. Griffith, Pregabalin overdose with benign outcome, Clinical Toxicology, vol.46, issue.9, p.917, 2008.
DOI : 10.1097/01.ftd.0000158874.54100.1a

F. Schifano, D. Offizi, S. Piccione, and M. , Is There a Recreational Misuse Potential for Pregabalin Analysis of Anecdotal Online Reports in Comparison with Related Gabapentin and Clonazepam Data, Psychotherapy and Psychosomatics, vol.80, issue.2, pp.118-140, 2011.
DOI : 10.1159/000321079

O. Caster, I. Edwards, and G. Noren, Earlier discovery of pregabalin???s dependence potential might have been possible, European Journal of Clinical Pharmacology, vol.19, issue.S1, pp.319-339, 2011.
DOI : 10.1007/s00228-010-0920-4

M. Grosshans, J. Mutschler, and D. Hermann, Pregabalin Abuse, Dependence, and Withdrawal: A Case Report, American Journal of Psychiatry, vol.167, issue.7, p.869, 2010.
DOI : 10.1176/appi.ajp.2010.09091269

S. Schwan, A. Sundstrom, and E. Stjernberg, A signal for an abuse liability for pregabalin???results from the Swedish spontaneous adverse drug reaction reporting system, European Journal of Clinical Pharmacology, vol.18, issue.1, pp.947-53, 2010.
DOI : 10.1007/s00228-010-0853-y
URL : https://hal.archives-ouvertes.fr/hal-00601560

N. Rouve, H. Bagheri, and N. Telmon, Prescribed drugs and violence: a case/noncase study in the French PharmacoVigilance Database, European Journal of Clinical Pharmacology, vol.5, issue.suppl 1, pp.1189-98, 2011.
DOI : 10.1007/s00228-011-1067-7