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Perfluorocarbon-loaded lipid nanocapsules as oxygen sensors for tumor tissue pO(2) assessment.: Fluorinated lipid nanocapsules as oxygen sensor

Laurent Lemaire 1, 2, * Guillaume Bastiat 3 Florence Franconi 2, 1 Nolwenn Lautram 1, 2 Than Duong Thi Dan 1, 2 Emmanuel Garcion 1, 2 Patrick Saulnier 1, 2 Jean-Pierre Benoit 1, 2
* Corresponding author
3 INSERM U1066
MINT - Micro et Nanomédecines Biomimétiques, CIFAB-PRIMEX
Abstract : The assessment of tumor oxygenation is a crucial factor in cancer therapy and may be carried out using fluorine MRI once fluorine probes have been distributed within the tumor. However, the deposit of those highly fluorinated compounds often jeopardizes anatomical image quality and requires emulsification of the probes. Due to the high density and the high lipophilicity of perfluorocarbons, nanoemulsion of these molecules usually requires high-energy processes. In the present work, we discuss the synthesis and the physico-chemical characterization of perfluorocarbon nanocapsules using a low-energy phase-inversion process. The nanocapsules were tested on a mouse tumor brain model to assess oxygenation.
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Submitted on : Tuesday, February 5, 2013 - 5:30:39 PM
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Laurent Lemaire, Guillaume Bastiat, Florence Franconi, Nolwenn Lautram, Than Duong Thi Dan, et al.. Perfluorocarbon-loaded lipid nanocapsules as oxygen sensors for tumor tissue pO(2) assessment.: Fluorinated lipid nanocapsules as oxygen sensor. European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2013, epub ahead of print. ⟨10.1016/j.ejpb.2013.01.003⟩. ⟨inserm-00785263⟩

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