Global circumferential left ventricular strain impairment in hypertrophic cardiomyopathy: comparison to left ventricular hypertrophy and late gadolinium enhancement

1532-429X-15-S1-E122 1532-429X Poster presentation Global circumferential left ventricular strain impairment in hypertrophic cardiomyopathy: comparison to left ventricular hypertrophy and late gadolinium enhancement MacronLaurent RedheuilAlban AshrafpoorGolmehr KachenouraNadjia BollacheEmilie HagègeA Albert DesnosMichel CroisillePierre ClaryssePatrick MousseauxElie

Radiology, Cardiovascular Imaging Unit, HEGP,APHP, Paris, France

Cardiology, HEGP,APHP, Paris, France

LIF, INSERM U678, UPMC, Paris, France

CREATIS, UMR CNRS 5220 - INSERM U1044, Lyon, France

Journal of Cardiovascular Magnetic Resonance Abstracts of the 16th Annual SCMR Scientific SessionsPublication of this supplement is fully supported by the Society for Cardiovascular Magnetic Resonance.Meeting abstracts16th Annual SCMR Scientific SessionsSan Francisco, CA, USA

31 January - 3 February 2013

http://www.scmr.org/1532-429X 2013 15 Suppl 1 E122 http://www.jcmr-online.com/content/15/S1/E122 10.1186/1532-429X-15-S1-E122 3012013 2013Macron et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

to evaluate the relationship between Left Ventricular (LV) myocardial strain, mass, wall thickness and the extent of fibrosis in hypertrophic cardiomyopathy (HCM)

Methods

Forty HCM patients and 20 matched controls underwent a comprehensive CMR including cine imaging, late gadolinium enhancement (LGE) and short axis tagging. Global peak circumferential LV strain (Ecc) was generated from tagging sequences using InTag®. LGE volume was quantified semi automatically using a 6SD threshold.

Results

HCM patients (50±18 years, 65% men) had normal LVEDV (149±46mL, p=0.24), LVESV (52±24mL, p=0.78) and LVEF (65±11%, p=0.38). LV mass (198±69g, p<0.001) and LV mass index (108±37g/m2 p=0.002) were significantly increased, resulting in decreased LV mass/LV volume ratio (1.40±0.54, p=0.005) in HCM compared to controls. Median maximal wall thickness was 19.6 (14.4 to 32.3mm). In HCM, LGE was present in 32/40 (80%) and mean LGE mass was 4.31±4.94g.

Ecc was significantly impaired in HCM patients (-8.82±0.32 vs. -15.54±2.54%, p<0.0001)

Ecc impairment was significantly associated with increased LV mass index (r=0.51, p=0.0009), LV mass/ LV volume ratio (r=0.67,p<0.0001) and LV maximal wall thickness (r=0.51, p=0.008). Moreover, Ecc impairment was associated with increased LGE mass (r=0.39, p=0.01).

Conclusions

Global LV circumferential myocardial deformation was strongly decreased in HCM and significantly associated with LV hypertrophy and the extent of LGE.

Funding

none