Changes in urine composition after trauma facilitate bacterial growth. - Archive ouverte HAL Access content directly
Journal Articles BMC Infectious Diseases Year : 2012

Changes in urine composition after trauma facilitate bacterial growth.

(1) , (2) , (2) , (3) , (4) , (2) , (1) , (5) , (1) , (2)
1
2
3
4
5
Olivier Huet
  • Function : Author
  • PersonId : 936024
Sylvie Ricome
  • Function : Author
  • PersonId : 914569
Didier Borderie
  • Function : Author
  • PersonId : 870568
Pierre-Etienne Leblanc
  • Function : Author
  • PersonId : 936026
Odile Bouvet
  • Function : Author
  • PersonId : 931801
Eric Vicaut
  • Function : Author
  • PersonId : 912409
Erick Denamur
  • Function : Author
  • PersonId : 860804
Jacques Duranteau
  • Function : Author
  • PersonId : 926440

Abstract

UNLABELLED: ABSTRACT: BACKGROUND: Critically ill patients including trauma patients are at high risk of urinary tract infection (UTI). The composition of urine in trauma patients may be modified due to inflammation, systemic stress, rhabdomyolysis, life support treatment and/or urinary catheter insertion. METHODS: Prospective, single-centre, observational study conducted in patients with severe trauma and without a history of UTIs or recent antibiotic treatment. The 24-hour urine samples were collected on the first and the fifth days and the growth of Escherichia coli in urine from patients and healthy volunteers was compared. Biochemical and hormonal modifications in urine that could potentially influence bacterial growth were explored. RESULTS: Growth of E. coli in urine from trauma patients was significantly higher on days 1 and 5 than in urine of healthy volunteers. Several significant modifications of urine composition could explain these findings. On days 1 and 5, trauma patients had an increase in glycosuria, in urine iron concentration, and in the concentrations of several amino acids compared to healthy volunteers. On day 1, the urinary osmotic pressure was significantly lower than for healthy volunteers. CONCLUSION: We showed that urine of trauma patients facilitated growth of E. coli when compared to urine from healthy volunteers. This effect was present in the first 24 hours and until at least the fifth day after trauma. This phenomenon may be involved in the pathophysiology of UTIs in trauma patients. Further studies are required to define the exact causes of such modifications.
Fichier principal
Vignette du fichier
1471-2334-12-330.pdf (391.22 Ko) Télécharger le fichier
Vignette du fichier
1471-2334-12-330.xml (100.86 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00781365 , version 1 (26-01-2013)

Identifiers

Cite

Cecile Aubron, Olivier Huet, Sylvie Ricome, Didier Borderie, Eric Pussard, et al.. Changes in urine composition after trauma facilitate bacterial growth.. BMC Infectious Diseases, 2012, 12 (1), pp.330. ⟨10.1186/1471-2334-12-330⟩. ⟨inserm-00781365⟩
127 View
225 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More