The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation, Proceedings of the National Academy of Sciences, vol.100, issue.3, pp.928-933, 2003. ,
DOI : 10.1073/pnas.0335507100
PCSK9 and LDL cholesterol: unravelling the target to design the bullet, Trends in Biochemical Sciences, vol.33, issue.9, pp.426-434, 2008. ,
DOI : 10.1016/j.tibs.2008.06.005
Molecular biology of PCSK9: its role in LDL metabolism, Trends in Biochemical Sciences, vol.32, issue.2, pp.71-77, 2007. ,
DOI : 10.1016/j.tibs.2006.12.008
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia, Mutations in PCSK9 cause autosomal dominant hypercholesterolemia, pp.154-156, 2003. ,
DOI : 10.1038/ng1161
Low LDL, and Protection against Coronary Heart Disease, New England Journal of Medicine, vol.354, issue.12, pp.1264-1272, 2006. ,
DOI : 10.1056/NEJMoa054013
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study, The Lancet, vol.380, issue.9858, pp.3802007-2017 ,
DOI : 10.1016/S0140-6736(12)61770-X
Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial, The Lancet, vol.380, issue.9836, pp.38029-38065 ,
DOI : 10.1016/S0140-6736(12)60771-5
Serum Proprotein Convertase Subtilisin Kexin Type 9 Is Correlated Directly with Serum LDL Cholesterol, Clinical Chemistry, vol.53, issue.10, pp.531814-1819, 2007. ,
DOI : 10.1373/clinchem.2007.091280
Plasma PCSK9 Is Associated with Age, Sex, and Multiple Metabolic Markers in a Population-Based Sample of Children and Adolescents, Clinical Chemistry, vol.55, issue.9, pp.551637-1645, 2009. ,
DOI : 10.1373/clinchem.2009.126987
A new method for measurement of total plasma PCSK9: clinical applications, The Journal of Lipid Research, vol.51, issue.1, pp.140-149, 2010. ,
DOI : 10.1194/jlr.M900273-JLR200
Genetic and Metabolic Determinants of Plasma PCSK9 Levels, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.7, pp.2537-2543, 2009. ,
DOI : 10.1210/jc.2009-0141
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice, The Journal of Lipid Research, vol.44, issue.11, pp.442109-2119, 2003. ,
DOI : 10.1194/jlr.M300203-JLR200
Statins Upregulate PCSK9, the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.24, issue.8, pp.241454-1459, 2004. ,
DOI : 10.1161/01.ATV.0000134621.14315.43
Hepatic PCSK9 Expression Is Regulated by Nutritional Status via Insulin and Sterol Regulatory Element-binding Protein 1c, Journal of Biological Chemistry, vol.281, issue.10, pp.2816211-6218, 2006. ,
DOI : 10.1074/jbc.M508582200
Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression, Cell Metabolism, vol.15, issue.6, pp.15873-884 ,
DOI : 10.1016/j.cmet.2012.05.002
Importance of Proprotein Convertase Subtilisin/Kexin Type 9 in the Hormonal and Dietary Regulation of Rat Liver Low-Density Lipoprotein Receptors, Endocrinology, vol.150, issue.3, pp.1140-1146, 2009. ,
DOI : 10.1210/en.2008-1281
Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans, The Journal of Lipid Research, vol.51, issue.11, pp.513359-3363, 2010. ,
DOI : 10.1194/jlr.P009860
Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.30, issue.12, pp.302666-2672, 2010. ,
DOI : 10.1161/ATVBAHA.110.214130
Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome, British Journal of Nutrition, vol.131, issue.05, pp.1-7, 2011. ,
DOI : 10.1001/jama.287.5.598
Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial, American Journal of Clinical Nutrition, vol.95, issue.5, pp.951003-1012 ,
DOI : 10.3945/ajcn.111.030114
No acute response of leptin to an oral fat load in obese patients and during circadian rhythm in healthy controls, European Journal of Endocrinology, vol.143, issue.5, pp.649-655, 2000. ,
DOI : 10.1530/eje.0.1430649
PCSK9 Dominant Negative Mutant Results in Increased LDL Catabolic Rate and Familial Hypobetalipoproteinemia, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.29, issue.12, pp.9-292191, 2009. ,
DOI : 10.1161/ATVBAHA.109.194191
High protein intake reduces intrahepatocellular lipid deposition in humans, American Journal of Clinical Nutrition, vol.90, issue.4, pp.1002-1010, 2009. ,
DOI : 10.3945/ajcn.2008.27296
Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes, American Journal of Clinical Nutrition, vol.89, issue.6, pp.891760-1765, 2009. ,
DOI : 10.3945/ajcn.2008.27336
Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans, American Journal of Clinical Nutrition, vol.96, issue.5, pp.961008-1016 ,
DOI : 10.3945/ajcn.112.035139
Isotopomer spectral analysis of intermediates of cholesterol synthesis in human subjects and hepatic cells, American Journal of Physiology - Endocrinology And Metabolism, vol.282, issue.6, pp.1222-1230, 2002. ,
DOI : 10.1152/ajpendo.00324.2001
Glucose clamp technique: a method for quantifying insulin secretion and resistance, Am J Physiol, vol.237, issue.3, pp.214-223, 1979. ,
Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia, Arterioscler Thromb Vasc Biol, issue.5, pp.29684-690, 2009. ,
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study, pp.1001-1009, 1997. ,
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes, New England Journal of Medicine, vol.350, issue.7, pp.664-671, 2004. ,
DOI : 10.1056/NEJMoa031314
Slow Glucose Removal Rate and Hyperinsulinemia Precede the Development of Type II Diabetes in the Offspring of Diabetic Parents, Annals of Internal Medicine, vol.113, issue.12, pp.909-915, 1990. ,
DOI : 10.7326/0003-4819-113-12-909
Selection of the appropriate method for the assessment of insulin resistance, BMC Medical Research Methodology, vol.63, issue.2, p.158, 2011. ,
DOI : 10.1006/mgme.1997.2658
Apolipoprotein B100 metabolism in autosomaldominant hypercholesterolemia related to mutations in PCSK9, Arterioscler Thromb Vasc Biol, issue.8, pp.241448-1453, 2004. ,
Fasting induces hyperlipidemia in mice overexpressing PCSK9: lack of modulation of VLDL hepatic output by the LDLr, Endocrinology, issue.10, pp.1474985-4995, 2006. ,
The role of the LDL receptor in apolipoprotein B secretion, Journal of Clinical Investigation, vol.105, issue.4, pp.521-532, 2000. ,
DOI : 10.1172/JCI8623
Metabolic Effects of Fructose and the Worldwide Increase in Obesity, Physiological Reviews, vol.90, issue.1, pp.23-46, 2010. ,
DOI : 10.1152/physrev.00019.2009
Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice, The Journal of Lipid Research, vol.50, issue.8, pp.501581-1588, 2009. ,
DOI : 10.1194/jlr.M800542-JLR200
Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2, The Journal of Lipid Research, vol.49, issue.2, pp.49399-409, 2007. ,
DOI : 10.1194/jlr.M700443-JLR200
SREBP transcription factors: master regulators of lipid homeostasis, Biochimie, vol.86, issue.11, pp.839-848, 2004. ,
DOI : 10.1016/j.biochi.2004.09.018
Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans, J Lipid Res, vol.29, issue.9, pp.1149-1155, 1988. ,
Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men, British Journal of Nutrition, vol.18, issue.02, pp.370-378, 2008. ,
DOI : 10.1194/jlr.M400167-JLR200
Dual Mechanisms for the Fibrate-mediated Repression of Proprotein Convertase Subtilisin/Kexin Type 9, Journal of Biological Chemistry, vol.283, issue.15, pp.2839666-9673, 2008. ,
DOI : 10.1074/jbc.M705831200
Delineation of molecular pathways that regulate hepatic PCSK9 and LDL receptor expression during fasting in normolipidemic hamsters, Atherosclerosis, vol.224, issue.2, pp.401-410 ,
DOI : 10.1016/j.atherosclerosis.2012.08.012
Delayed chylomicron remnant clearance in subjects with heterozygous familial hypercholesterolaemia, Journal of Internal Medicine, vol.38, issue.4, pp.299-307, 1998. ,
DOI : 10.1016/0021-9150(94)05430-Q
Lack of evidence for reduced plasma apo B48 catabolism in patients with heterozygous familial hypercholesterolemia carrying the same null LDL receptor gene mutation, Atherosclerosis, vol.172, issue.2, pp.367-373, 2004. ,
DOI : 10.1016/j.atherosclerosis.2003.11.011
Diabetes alters LDL receptor and PCSK9 expression in rat liver, Archives of Biochemistry and Biophysics, vol.470, issue.2, pp.111-115, 2008. ,
DOI : 10.1016/j.abb.2007.11.009
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities, FEBS Letters, vol.37, issue.4, pp.701-706, 2009. ,
DOI : 10.1016/j.febslet.2009.12.018
PCSK9 is expressed in pancreatic ??-cells and does not alter insulin secretion, Biochemical and Biophysical Research Communications, vol.390, issue.4, pp.1288-1293, 2009. ,
DOI : 10.1016/j.bbrc.2009.10.138
Fructose and metabolic diseases: New findings, new questions, Nutrition, vol.26, issue.11-12, pp.11-121044 ,
DOI : 10.1016/j.nut.2010.02.014
Association between plasma PCSK9 and gamma-glutamyl transferase levels in diabetic patients, Atherosclerosis, vol.211, issue.2, pp.700-702, 2010. ,
DOI : 10.1016/j.atherosclerosis.2010.04.015