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Research needs in allergy: an EAACI position paper, in collaboration with EFA.

Nikolaos Papadopoulos 1, * Ioana Agache 2 Sevim Bavbek 3 Beatrice Bilo 4 Fulvio Braido 5 Victoria Cardona 6 Adnan Custovic 7 Jan Demonchy 8 Pascal Demoly 9 Philippe Eigenmann 10 Jacques Gayraud 11 Clive Grattan 12 Enrico Heffler 13 Peter Hellings 14 Marek Jutel 15 Edward Knol 16 Jan Lötvall 17 Antonella Muraro 18 Lars Poulsen 19 Graham Roberts 20 Peter Schmid-Grendelmeier 21 Chrysanthi Skevaki 1 Massimo Triggiani 22 Ronald Vanree 23 Thomas Werfel 24 Breda Flood 25 Susanna Palkonen 25 Roberta Savli 25 Pia Allegri 26 Isabella Annesi-Maesano 27 Francesco Annunziato 28 Dario Antolin-Amerigo 29 Christian Apfelbacher 30 Miguel Blanca 31 Ewa Bogacka 32 Patrizia Bonadonna 33 Matteo Bonini 34 Onur Boyman 21 Knut Brockow 35 Peter Burney 36 Jeroen Buters 37 Indre Butiene 38 Moises Calderon 39 Lars Cardell 40 Jean-Christoph Caubet 41 Sevcan Celenk 42 Ewa Cichocka-Jarosz 43 Cemal Cingi 44 Mariana Couto 45 Nicolette Dejong 46 Stefano del Giacco 47 Nikolaos Douladiris 1 Filippo Fassio 48 Jean-Luc Fauquert 49 Javier Fernandez 50 Montserrat Rivas 51 Marta Ferrer 52 Carsten Flohr 53 James Gardner 54 Jon Genuneit 55 Philippe Gevaert 56 Anna Groblewska 57 Eckard Hamelmann 58 Hans Hoffmann 59 Karin Hoffmann-Sommergruber 60 Lilit Hovhannisyan 61 Valérie Hox 14 Frode Jahnsen 62 Ömer Kalayci 63 Ayse Kalpaklioglu 64 Jörg Kleine-Tebbe 64 George Konstantinou 65 Marcin Kurowski 66 Susanne Lau 67 Roger Lauener 68 Antti Lauerma 69 Kirsty Logan 70 Antoine Magnan 71 Joanna Makowska 72 Heidi Makrinioti 36 Paraskevi Mangina 1 Felicia Manole 73 Adriano Mari 74 Angel Mazon 75 Clare Mills 76 Ervinç Mingomataj 77 Bodo Niggemann 78 Gunnar Nilsson 79 Markus Ollert 80 Liam O'Mahony 81 Serena O'Neil 17 Gianni Pala 82 Alberto Papi 83 Gianni Passalacqua 84 Michael Perkin 71 Oliver Pfaar 85 Constantinos Pitsios 86 Santiago Quirce 87 Ulrike Raap 24 Monika Raulf-Heimsoth 88 Claudio Rhyner 83 Paula Robson-Ansley 89 Rodrigo Alves 90 Zeljka Roje 91 Carmen Rondon 92 Odilija Rudzeviciene 93 Franziska Ruëff 94 Maia Rukhadze 95 Gabriele Rumi 96 Cansin Sackesen 97 Alexandra Santos 98, 99 Annalisa Santucci 100 Christian Scharf 101 Carsten Schmidt-Weber 102 Benno Schnyder 103 Jürgen Schwarze 104 Gianenrico Senna 105 Svetlana Sergejeva 106 Sven Seys 107 Andrea Siracusa 108 Isabel Skypala 39 Milena Sokolowska 109 Francois Spertini 110 Radoslaw Spiewak 111 Aline Sprikkelman 112 Gunter Sturm 113 Ines Swoboda 60 Ingrid Terreehorst 114 Elina Toskala 115 Claudia Traidl-Hoffmann 35 Carina Venter 116 Berber Vlieg-Boerstra 46, 83 Paul Whitacker 117 Margitta Worm 118 Paraskevi Xepapadaki 1 Cezmi Akdis 83
* Corresponding author
117 SpR
Abstract : ABSTRACT: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.
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Nikolaos Papadopoulos, Ioana Agache, Sevim Bavbek, Beatrice Bilo, Fulvio Braido, et al.. Research needs in allergy: an EAACI position paper, in collaboration with EFA.. Clinical and Translational Allergy, BioMed Central, 2012, 2 (1), pp.21. ⟨10.1186/2045-7022-2-21⟩. ⟨inserm-00771547⟩

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