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Journal Articles Clinical and Translational Allergy Year : 2012

Research needs in allergy: an EAACI position paper, in collaboration with EFA.

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Nikolaos Papadopoulos
  • Function : Correspondent author
  • PersonId : 933632

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Ioana Agache
  • Function : Author
  • PersonId : 934973
Sevim Bavbek
  • Function : Author
  • PersonId : 934974
Beatrice Bilo
  • Function : Author
  • PersonId : 934975
Fulvio Braido
  • Function : Author
  • PersonId : 873328
Adnan Custovic
  • Function : Author
  • PersonId : 934976
Jan Demonchy
  • Function : Author
  • PersonId : 934977
Pascal Demoly
Philippe Eigenmann
  • Function : Author
  • PersonId : 934978
Jacques Gayraud
  • Function : Author
  • PersonId : 934979
Clive Grattan
  • Function : Author
  • PersonId : 934980
Enrico Heffler
  • Function : Author
  • PersonId : 934981
Marek Jutel
  • Function : Author
  • PersonId : 934983
Jan Lötvall
  • Function : Author
  • PersonId : 933617
Antonella Muraro
  • Function : Author
  • PersonId : 933620
Lars Poulsen
  • Function : Author
  • PersonId : 934985
Graham Roberts
  • Function : Author
  • PersonId : 903316
Chrysanthi Skevaki
  • Function : Author
  • PersonId : 934987
Massimo Triggiani
  • Function : Author
  • PersonId : 863303
Ronald Vanree
  • Function : Author
  • PersonId : 894404
Thomas Werfel
  • Function : Author
  • PersonId : 934988
Breda Flood
  • Function : Author
  • PersonId : 934989
Susanna Palkonen
  • Function : Author
  • PersonId : 934990
Roberta Savli
  • Function : Author
  • PersonId : 934991
Pia Allegri
  • Function : Author
  • PersonId : 934992
Francesco Annunziato
  • Function : Author
  • PersonId : 934993
Dario Antolin-Amerigo
  • Function : Author
  • PersonId : 934994
Christian Apfelbacher
  • Function : Author
  • PersonId : 934995
Miguel Blanca
  • Function : Author
  • PersonId : 934996
Patrizia Bonadonna
  • Function : Author
  • PersonId : 934998
Matteo Bonini
  • Function : Author
  • PersonId : 934999
Onur Boyman
  • Function : Author
  • PersonId : 935000
Knut Brockow
  • Function : Author
  • PersonId : 935001
Peter Burney
  • Function : Author
  • PersonId : 935002
Jeroen Buters
  • Function : Author
  • PersonId : 935003
Indre Butiene
  • Function : Author
  • PersonId : 935004
Moises Calderon
  • Function : Author
  • PersonId : 933589
Lars Olaf Cardell
  • Function : Author
  • PersonId : 935005
Sevcan Celenk
  • Function : Author
  • PersonId : 935007
Ewa Cichocka-Jarosz
  • Function : Author
  • PersonId : 934997
Mariana Couto
  • Function : Author
  • PersonId : 935009
Nicolette Dejong
  • Function : Author
  • PersonId : 935010
Nikolaos Douladiris
  • Function : Author
  • PersonId : 935012
Filippo Fassio
  • Function : Author
  • PersonId : 935013
Jean-Luc Fauquert
  • Function : Author
  • PersonId : 935014
Javier Fernandez
  • Function : Author
  • PersonId : 935015
Montserrat Fernandez Rivas
  • Function : Author
  • PersonId : 933612
Marta Ferrer
  • Function : Author
  • PersonId : 935016
Carsten Flohr
  • Function : Author
  • PersonId : 935017
James Gardner
  • Function : Author
  • PersonId : 935018
Philippe Gevaert
  • Function : Author
  • PersonId : 935019
Eckard Hamelmann
  • Function : Author
  • PersonId : 935021
Hans Jürgen Hoffmann
  • Function : Author
  • PersonId : 935022
Lilit Hovhannisyan
  • Function : Author
  • PersonId : 935024
Frode Jahnsen
  • Function : Author
  • PersonId : 935026
Ömer Kalayci
  • Function : Author
  • PersonId : 935027
Marcin Kurowski
  • Function : Author
  • PersonId : 935030
Roger Lauener
  • Function : Author
  • PersonId : 935032
Antti Lauerma
  • Function : Author
  • PersonId : 935033
Kirsty Logan
  • Function : Author
  • PersonId : 935034
Antoine Magnan
  • Function : Author
  • PersonId : 915020
Heidi Makrinioti
  • Function : Author
  • PersonId : 935036
Paraskevi Mangina
  • Function : Author
  • PersonId : 935037
Felicia Manole
  • Function : Author
  • PersonId : 935038
Adriano Mari
  • Function : Author
  • PersonId : 935039
Angel Mazon
  • Function : Author
  • PersonId : 935040
Clare Mills
  • Function : Author
  • PersonId : 935041
Bodo Niggemann
  • Function : Author
  • PersonId : 935043
Serena O'Neil
  • Function : Author
  • PersonId : 935046
Gianni Pala
  • Function : Author
  • PersonId : 935047
Alberto Papi
  • Function : Author
  • PersonId : 935048
Gianni Passalacqua
  • Function : Author
  • PersonId : 933623
Michael Perkin
  • Function : Author
  • PersonId : 935049
Oliver Pfaar
  • Function : Author
  • PersonId : 933624
Constantinos Pitsios
  • Function : Author
  • PersonId : 935050
Ulrike Raap
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  • PersonId : 935052
Claudio Rhyner
  • Function : Author
  • PersonId : 935054
Paula Robson-Ansley
  • Function : Author
  • PersonId : 935055
Zeljka Roje
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  • PersonId : 935057
Carmen Rondon
  • Function : Author
  • PersonId : 935058
Odilija Rudzeviciene
  • Function : Author
  • PersonId : 935059
Franziska Ruëff
  • Function : Author
  • PersonId : 935060
Maia Rukhadze
  • Function : Author
  • PersonId : 935061
Gabriele Rumi
  • Function : Author
  • PersonId : 935062
Cansin Sackesen
  • Function : Author
  • PersonId : 935063
Annalisa Santucci
  • Function : Author
  • PersonId : 935065
Christian Scharf
  • Function : Author
  • PersonId : 935066
Jürgen Schwarze
  • Function : Author
  • PersonId : 935069
Gianenrico Senna
  • Function : Author
  • PersonId : 933626
Svetlana Sergejeva
  • Function : Author
  • PersonId : 935070
Sven Seys
  • Function : Author
  • PersonId : 935071
Andrea Siracusa
  • Function : Author
  • PersonId : 935072
Isabel Skypala
  • Function : Author
  • PersonId : 935073
Milena Sokolowska
  • Function : Author
  • PersonId : 935074
Gunter Sturm
  • Function : Author
  • PersonId : 935078
Ingrid Terreehorst
  • Function : Author
  • PersonId : 935080
Elina Toskala
  • Function : Author
  • PersonId : 935081
Claudia Traidl-Hoffmann
  • Function : Author
  • PersonId : 935082
Carina Venter
  • Function : Author
  • PersonId : 935083
Paul Whitacker
  • Function : Author
  • PersonId : 935085
SpR
Margitta Worm
  • Function : Author
  • PersonId : 935086
Paraskevi Xepapadaki
  • Function : Author
  • PersonId : 935087
Cezmi Akdis
  • Function : Author
  • PersonId : 933599

Abstract

ABSTRACT: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.
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Dates and versions

inserm-00771547 , version 1 (08-01-2013)

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Nikolaos Papadopoulos, Ioana Agache, Sevim Bavbek, Beatrice Bilo, Fulvio Braido, et al.. Research needs in allergy: an EAACI position paper, in collaboration with EFA.. Clinical and Translational Allergy, 2012, 2 (1), pp.21. ⟨10.1186/2045-7022-2-21⟩. ⟨inserm-00771547⟩
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