P. Boor, T. Ostendorf, and J. Floege, Renal fibrosis: novel insights into mechanisms and therapeutic targets, Nature Reviews Nephrology, vol.22, issue.11, pp.643-656, 2010.
DOI : 10.1038/nrneph.2010.120

B. Bielesz, Y. Sirin, and H. Si, Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans, Journal of Clinical Investigation, vol.120, issue.11, pp.4040-4054, 2010.
DOI : 10.1172/JCI43025DS1

R. Kopan, H. Cheng, and K. Surendran, Molecular Insights into Segmentation along the Proximal Distal Axis of the Nephron, Journal of the American Society of Nephrology, vol.18, issue.7, pp.2014-2020, 2007.
DOI : 10.1681/ASN.2007040453

C. Lin, F. Wang, and Y. Hsu, Modulation of Notch-1 Signaling Alleviates Vascular Endothelial Growth Factor???Mediated Diabetic Nephropathy, Diabetes, vol.59, issue.8, pp.1915-1925, 2010.
DOI : 10.2337/db09-0663

M. Murea, J. Park, and S. Sharma, Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function, Kidney International, vol.78, issue.5, pp.514-522, 2010.
DOI : 10.1038/ki.2010.172

T. Niranjan, B. Bielesz, and A. Gruenwald, The Notch pathway in podocytes plays a role in the development of glomerular disease, Nature Medicine, vol.139, issue.3, pp.290-298, 2008.
DOI : 10.1038/nm1731

P. Mertens, U. Raffetseder, and T. Rauen, Notch receptors: a new target in glomerular diseases, Nephrology Dialysis Transplantation, vol.23, issue.9, pp.2743-2745, 2008.
DOI : 10.1093/ndt/gfn279

R. Sanalkumar, S. Dhanesh, and J. J. , Non-canonical activation of Notch signaling/target genes in vertebrates, Cellular and Molecular Life Sciences, vol.3, issue.17, pp.2957-2968
DOI : 10.1007/s00018-010-0391-x

R. Kopan and M. Ilagan, The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism, Cell, vol.137, issue.2, pp.216-233, 2009.
DOI : 10.1016/j.cell.2009.03.045

T. Rauen, U. Raffetseder, and B. Frye, YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation, Journal of Biological Chemistry, vol.284, issue.39, pp.26928-26940, 2009.
DOI : 10.1074/jbc.M109.046599

U. Raffetseder, T. Rauen, and P. Boor, Extracellular YB-1 Blockade in Experimental Nephritis Upregulates Notch-3 Receptor Expression and Signaling, Nephron Experimental Nephrology, vol.118, issue.4, pp.100-108
DOI : 10.1159/000324209

D. Teachey, A. Seif, and V. Brown, Targeting Notch signaling in autoimmune and lymphoproliferative disease, Blood, vol.111, issue.2, pp.705-714, 2008.
DOI : 10.1182/blood-2007-05-087353

T. Niranjan, M. Murea, and K. Susztak, The Pathogenic Role of Notch Activation in Podocytes, Nephron Experimental Nephrology, vol.111, issue.4, pp.73-79, 2009.
DOI : 10.1159/000209207

U. Raffetseder, T. Rauen, and S. Djudjaj, Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein- 1 Complement C5 mediates experimental tubulointerstitial fibrosis, Kidney Int J Am Soc Nephrol, vol.75, issue.18, pp.185-196, 2007.

H. Weng, Y. Liu, and J. Chen, The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis The peroxisome proliferator-activated receptor-alpha agonist, BAY PP1, attenuates renal fibrosis in rats, Hepatology Kidney Int, vol.50, issue.80, pp.230-243, 2009.

C. Cohen, M. Lindenmeyer, and F. Eichinger, Improved Elucidation of Biological Processes Linked to Diabetic Nephropathy by Single Probe-Based Microarray Data Analysis, PLoS ONE, vol.65, issue.8, pp.522-528, 2002.
DOI : 10.1371/journal.pone.0002937.s005

C. Cohen, A. Klingenhoff, and A. Boucherot, Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins, Proceedings of the National Academy of Sciences, vol.103, issue.15, pp.5682-5687, 2006.
DOI : 10.1073/pnas.0511257103

U. Raffetseder, T. Rauen, and P. Boor, Extracellular YB-1 Blockade in Experimental Nephritis Upregulates Notch-3 Receptor Expression and Signaling, Nephron Experimental Nephrology, vol.118, issue.4, pp.100-108, 2011.
DOI : 10.1159/000324209

L. Krebs, Y. Xue, and C. Norton, Characterization ofNotch3-deficient mice: Normal embryonic development and absence of genetic interactions with aNotch1 mutation, genesis, vol.10, issue.3, pp.139-143, 2003.
DOI : 10.1002/gene.10241

N. Docherty, I. Calvo, and M. Quinlan, Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction, Kidney International, vol.75, issue.2, pp.205-213, 2009.
DOI : 10.1038/ki.2008.482

H. Cheng, M. Kim, and M. Valerius, Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron, Development, vol.134, issue.4, pp.801-811, 2007.
DOI : 10.1242/dev.02773

H. Cheng and R. Kopan, The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney, Kidney International, vol.68, issue.5, pp.1951-1952, 2005.
DOI : 10.1111/j.1523-1755.2005.00627.x

H. Cheng, J. Miner, and M. Lin, ??-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney, Development, vol.130, issue.20, pp.5031-5042, 2003.
DOI : 10.1242/dev.00697

S. Sharma, Y. Sirin, and K. Susztak, The story of Notch and chronic kidney disease, Current Opinion in Nephrology and Hypertension, vol.20, issue.1, pp.56-61, 2011.
DOI : 10.1097/MNH.0b013e3283414c88

P. Wang, F. Pereira, and D. Beasley, Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis, Development, vol.130, issue.20, pp.5019-5029, 2003.
DOI : 10.1242/dev.00682

A. Joutel, C. Corpechot, and A. Ducros, Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia, Nature, vol.383, issue.6602, pp.707-710, 1996.
DOI : 10.1038/383707a0

A. Joutel, M. Monet, and V. Domenga, Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway, The American Journal of Human Genetics, vol.74, issue.2, pp.338-347, 2004.
DOI : 10.1086/381506

N. Boulos, F. Helle, and J. Dussaule, Notch3 Is Essential for Regulation of the Renal Vascular Tone, Hypertension, vol.57, issue.6, pp.1176-1182, 2011.
DOI : 10.1161/HYPERTENSIONAHA.111.170746

A. Chung, X. Huang, and L. Zhou, Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice, Nephrology Dialysis Transplantation, vol.24, issue.5, pp.1443-1454, 2009.
DOI : 10.1093/ndt/gfn699

K. Inazaki, Y. Kanamaru, and Y. Kojima, Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction, Kidney International, vol.66, issue.2, pp.597-604, 2004.
DOI : 10.1111/j.1523-1755.2004.00779.x
URL : http://doi.org/10.1111/j.1523-1755.2004.00779.x

B. Perez-cabezas, M. Naranjo-gomez, and P. Bastos-amador, Ligation of Notch Receptors in Human Conventional and Plasmacytoid Dendritic Cells Differentially Regulates Cytokine and Chemokine Secretion and Modulates Th Cell Polarization, The Journal of Immunology, vol.186, issue.12, pp.7006-7015, 2011.
DOI : 10.4049/jimmunol.1100203

J. Shi, M. Fallahi, and J. Luo, Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis, Blood, vol.118, issue.9, pp.2511-2519, 2011.
DOI : 10.1182/blood-2011-04-346726

H. Reich, D. Tritchler, and D. Cattran, A Molecular Signature of Proteinuria in Glomerulonephritis, PLoS ONE, vol.58, issue.10, p.13451, 2010.
DOI : 10.1371/journal.pone.0013451.s001