B. Battistini, N. Berthiaume, N. Kelland, D. Webb, and D. Kohan, Profile of past and current clinical trials involving endothelin receptor antagonists: the novel " -sentan " class of drug, Exp Biol Med, vol.231, pp.653-695, 2006.

M. Barton and M. Yanagisawa, Endothelin, American Journal of Hypertension, vol.11, issue.4, pp.485-498, 2008.
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M. Barton and D. Kohan, Endothelin Antagonists in Clinical Trials: Lessons Learned, Contrib Nephrol, vol.172, pp.255-260, 2011.
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J. Mann, D. Green, K. Jamerson, L. Ruilope, S. Kuranoff et al., Avosentan for Overt Diabetic Nephropathy, Journal of the American Society of Nephrology, vol.21, issue.3, pp.527-535, 2010.
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J. Nelson, W. Love, J. Chin, F. Saad, C. Schulman et al., Phase 3, randomized, controlled trial of atrasentan in patients with nonmetastatic, hormone-refractory prostate cancer, Cancer, vol.97, issue.9, pp.2478-2487, 2008.
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D. Kohan, N. Rossi, E. Inscho, and D. Pollock, Regulation of Blood Pressure and Salt Homeostasis by Endothelin, Physiological Reviews, vol.91, issue.1, pp.1-77, 2011.
DOI : 10.1152/physrev.00060.2009

Y. Ge, P. Stricklett, A. Hughes, M. Yanagisawa, and D. Kohan, Collecting ductspecific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure, Am J Physiol, vol.289, issue.4, pp.692-698, 2005.

M. Traykova-brauch, K. Schönig, O. Greiner, T. Miloud, A. Jauch et al., An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice, Nature Medicine, vol.35, issue.9, pp.979-984, 2008.
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M. Chapman, L. Hu, C. Plato, and D. Kohan, Bioimpedance spectroscopy for the estimation of body fluid volumes in mice, AJP: Renal Physiology, vol.299, issue.1, pp.280-283, 2010.
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V. Bugaj, O. Pochynyuk, E. Mironova, A. Vandewalle, J. Medina et al., Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct, AJP: Renal Physiology, vol.295, issue.4, pp.1063-1070, 2008.
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V. Bugaj, E. Mironova, D. Kohan, and J. Stockand, Collecting duct-specific endothelin B receptor knockout increases ENaC activity, AJP: Cell Physiology, vol.302, issue.1, pp.188-194, 2012.
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Y. Ge, A. Bagnall, P. Stricklett, K. Strait, D. Webb et al., Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention, AJP: Renal Physiology, vol.291, issue.6, pp.1274-1280, 2006.
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Y. Ge, A. Bagnall, P. Stricklett, D. Webb, Y. Kotelevtsev et al., Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention, AJP: Renal Physiology, vol.295, issue.6, pp.1635-1640, 2008.
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D. Nakano and D. Pollock, Contribution of Endothelin A Receptors in Endothelin 1-Dependent Natriuresis in Female Rats, Hypertension, vol.53, issue.2, pp.324-330, 2009.
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N. Evans and J. Walker, signaling and delayed internalization associated with endothelin receptor heterodimers linked through a PDZ fingerThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin., Canadian Journal of Physiology and Pharmacology, vol.86, issue.8, pp.526-535, 2008.
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B. Gregan, J. Jurgensen, G. Papsdorf, J. Furkert, M. Schaefer et al., Ligand-dependent Differences in the Internalization of Endothelin A and Endothelin B Receptor Heterodimers, Journal of Biological Chemistry, vol.279, issue.26, pp.27679-27687, 2004.
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D. Kohan, Y. Pritchett, M. Molitch, S. Wen, T. Garimella et al., Addition of Atrasentan to Renin-Angiotensin System Blockade Reduces Albuminuria in Diabetic Nephropathy, Journal of the American Society of Nephrology, vol.22, issue.4, pp.763-772, 2011.
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G. Bakris, L. Lindholm, H. Black, H. Krum, S. Linas et al., Divergent Results Using Clinic and Ambulatory Blood Pressures: Report of a Darusentan-Resistant Hypertension Trial, Hypertension, vol.56, issue.5, pp.824-830, 2010.
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. Stuart, Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion, BMC Nephrology, vol.56, issue.4, p.166, 2012.
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