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Journal articles
Intramyocardial delivery of mesenchymal stem cell-seeded hydrogel preserves cardiac function and attenuates ventricular remodeling after myocardial infarction.
Abstract : BACKGROUND: To improve the efficacy of bone marrow-derived mesenchymal stem cell (MSC) therapy targeted to infarcted myocardium, we investigated whether a self-setting silanized hydroxypropyl methylcellulose (Si-HPMC) hydrogel seeded with MSC (MSC+hydrogel) could preserve cardiac function and attenuate left ventricular (LV) remodeling during an 8-week follow-up study in a rat model of myocardial infarction (MI). METHODOLOGY/PRINCIPAL FINDING: Si-HPMC hydrogel alone, MSC alone or MSC+hydrogel were injected into the myocardium immediately after coronary artery ligation in female Lewis rats. Animals in the MSC+hydrogel group showed an increase in cardiac function up to 28 days after MI and a mid-term prevention of cardiac function alteration at day 56. Histological analyses indicated that the injection of MSC+hydrogel induced a decrease in MI size and an increase in scar thickness and ultimately limited the transmural extent of MI. These findings show that intramyocardial injection of MSC+hydrogel induced short-term recovery of ventricular function and mid-term attenuation of remodeling after MI. CONCLUSION/SIGNIFICANCE: These beneficial effects may be related to the specific scaffolding properties of the Si-HPMC hydrogel that may provide the ability to support MSC injection and engraftment within myocardium.
Cited literature [58 references]
https://www.hal.inserm.fr/inserm-00770250
Contributor : Patricia Lemarchand <>
Submitted on : Friday, January 4, 2013 - 6:18:22 PM
Last modification on : Friday, June 11, 2021 - 4:20:07 PM
Long-term archiving on: : Friday, April 5, 2013 - 5:59:08 AM
Contributor : Patricia Lemarchand <>
Submitted on : Friday, January 4, 2013 - 6:18:22 PM
Last modification on : Friday, June 11, 2021 - 4:20:07 PM
Long-term archiving on: : Friday, April 5, 2013 - 5:59:08 AM
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Mathieu_et_al_2012_PlosOne.pdf
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