Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2012

Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.

Philippos Mourikis

Résumé

Skeletal muscle regeneration mainly depends on satellite cells, a population of resident muscle stem cells. However, our understanding of the molecular mechanisms underlying satellite cell activation is still largely undefined. Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression toward the myogenic lineage. Conditional inactivation of cripto in adult satellite cells compromises skeletal muscle regeneration, whereas gain of function of Cripto accelerates regeneration, leading to muscle hypertrophy. Moreover, we provide evidence that Cripto modulates myogenic cell determination and promotes proliferation by antagonizing the TGF-β ligand myostatin. Our data provide unique insights into the molecular and cellular basis of Cripto activity in skeletal muscle regeneration and raise previously undescribed implications for stem cell biology and regenerative medicine.
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Dates et versions

inserm-00769969 , version 1 (05-05-2013)

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Ombretta Guardiola, Peggy Lafuste, Silvia Brunelli, Salvatore Iaconis, Thierry Touvier, et al.. Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (47), pp.E3231-40. ⟨10.1073/pnas.1204017109⟩. ⟨inserm-00769969⟩
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