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Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.

Abstract : BACKGROUND: In contrast with human T-cell leukemia virus type 1 (HTLV-1) that causes ATL (adult T-cell leukemia), HTLV-2 has not been causally linked to malignant disease. The minus strand of the HTLV genomes encode the regulatory proteins HTLV-1 bZIP factor (HBZ) for HTLV-1 and antisense protein of HTLV-2 (APH-2) for HTLV-2. Unlike the viral proteins Tax1 and Tax2, both HBZ and APH-2 are constitutively expressed in infected cells suggesting that they may play important roles in the pathogenesis of these viruses. To date, very little is known about the function of APH-2 except that it inhibits Tax2-mediated transcription of HTLV-2 genes. In the present study, we investigated the role of APH-2 in basal and Tax2B-mediated activation of the AP-1 pathway. RESULTS: We demonstrate that, unlike HBZ, APH-2 stimulates basal AP-1 transcription by interacting with c-Jun and JunB through its non-conventional bZIP domain. In addition, when Tax2 and APH-2 are co-expressed, they physically interact in vivo and in vitro and APH-2 acts as an inhibitor of Tax2-mediated activation of AP-1 transcription. CONCLUSIONS: This report is the first to document that HTLV-2 can modulate the AP-1 pathway. Altogether our results reveal that, in contrast with HBZ, APH-2 regulates AP-1 activity in a Tax2-dependant manner. As the AP-1 pathway is involved in numerous cellular functions susceptible to affect the life cycle of the virus, these distinct biological properties between HBZ and APH-2 may contribute to the differential pathogenic potential of HTLV-1 and HTLV-2.
keyword : HTLV-2 APH-2 Tax2 AP-1 Jun
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Submitted on : Thursday, December 27, 2012 - 9:07:26 PM
Last modification on : Monday, December 18, 2017 - 1:02:19 AM
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Céline Marban, Áine Mccabe, Terence Bukong, William Hall, Noreen Sheehy. Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.. Retrovirology, BioMed Central, 2012, 9 (1), pp.98. ⟨10.1186/1742-4690-9-98⟩. ⟨inserm-00769054⟩



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