Flow (shear stress)-mediated remodeling of resistance arteries in diabetes.

Abstract : Shear stress due to blood flow is the most important force stimulating vascular endothelium. Acute stimulation of the endothelium by shear stress induces a vasodilatation mainly due to the release of nitric oxide (NO) among other relaxing agents. After a chronic increase in blood flow (shear stress), the endothelium triggers diameter enlargement, medial hypertrophy and improvement of arterial contractility and endothelium-mediated dilation. Shear stress-mediated outward remodeling requires an initial inflammatory response followed by the production of reactive oxygen species (ROS) and peroxinitrite anions, which activate MMPs and extracellular matrix digestion allowing diameter expansion. This outward remodeling occurs in collateral growth following occlusion of a large artery. In diabetes, an excessive ROS production is associated with the formation of advanced glycation end-products (AGEs) and the glycation of enzymes involved in vascular tone. The balance between inflammation, AGEs and ROS level determines the ability of resistance arteries to develop outward remodeling whereas AGEs and ROS contribute to decrease endothelium-mediated dilation in remodeled vessels. This review explores the interaction between ROS, AGEs and the endothelium in shear stress-mediated outward remodeling of resistance arteries in diabetes. Restoring or maintaining this remodeling is essential for an efficient blood flow in distal organs.
Type de document :
Article dans une revue
Vascular Pharmacology, Elsevier, 2012, 57 (5-6), pp.173-8. 〈10.1016/j.vph.2012.03.006〉
Liste complète des métadonnées

Littérature citée [69 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00768638
Contributeur : Daniel Henrion <>
Soumis le : samedi 22 décembre 2012 - 14:29:23
Dernière modification le : lundi 5 février 2018 - 15:00:08
Document(s) archivé(s) le : samedi 23 mars 2013 - 03:47:04

Fichier

Vessieres_VPH_2012.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Emilie Vessières, Mohamed Freidja, Laurent Loufrani, Céline Fassot, Daniel Henrion. Flow (shear stress)-mediated remodeling of resistance arteries in diabetes.. Vascular Pharmacology, Elsevier, 2012, 57 (5-6), pp.173-8. 〈10.1016/j.vph.2012.03.006〉. 〈inserm-00768638〉

Partager

Métriques

Consultations de la notice

356

Téléchargements de fichiers

284