Neisseria meningitidis colonization of the brain endothelium and cerebrospinal fluid invasion.: N. meningitidis infection of the brain endothelium

Florence Miller 1 Hervé Lécuyer 1, 2 Olivier Join-Lambert 1, 2 Sandrine Bourdoulous 3 Stefano Marullo 3 Xavier Nassif 1, 2 Mathieu Coureuil 1, *
* Auteur correspondant
1 UMR_S 570 - Pathogénie des infections systémiques
2 Service de Microbiologie
3 UM3 (UMR 8104 / U1016) - Institut Cochin
Abstract : The brain and meningeal spaces are protected from bacterial invasion by the blood brain barrier, formed by specialized endothelial cells and tight intercellular junctional complexes. However, once in the bloodstream, N. meningitidis crosses this barrier in about 60% of the cases. This highlights the particular efficacy with which N. meningitidis targets the brain vascular cell wall. The first step of central nervous system invasion is the direct interaction between bacteria and endothelial cells. This step is mediated by the type IV pili, which induce a remodeling of the endothelial monolayer, leading to the opening of the intercellular space. In this review, strategies used by the bacteria to survive in the bloodstream, to colonize the brain vasculature and to cross the blood brain barrier will be discussed.
Type de document :
Article dans une revue
Cellular Microbiology, Wiley, 2012, epub ahead of print. 〈10.1111/cmi.12082〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00767249
Contributeur : Mathieu Coureuil <>
Soumis le : mercredi 30 octobre 2013 - 14:26:18
Dernière modification le : jeudi 30 août 2018 - 01:10:48
Document(s) archivé(s) le : vendredi 31 janvier 2014 - 04:30:27

Fichier

cmi12082.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

UNIV-PARIS5 | USPC

Citation

Florence Miller, Hervé Lécuyer, Olivier Join-Lambert, Sandrine Bourdoulous, Stefano Marullo, et al.. Neisseria meningitidis colonization of the brain endothelium and cerebrospinal fluid invasion.: N. meningitidis infection of the brain endothelium. Cellular Microbiology, Wiley, 2012, epub ahead of print. 〈10.1111/cmi.12082〉. 〈inserm-00767249〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

524

Téléchargements de fichiers

471

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD