Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.

Coureuil Mathieu 1, * Guillain Mikaty 2 Florence Miller 3 Hervé Lécuyer 2 Christine Bernard 2 Sandrine Bourdoulous 3 Guillaume Duménil 2 René-Marc Mège 4 Babette Weksler 5 Ignacio Romero 6 Pierre-Olivier Couraud 3 Xavier Nassif 2
* Auteur correspondant
1 INSERM U1002
UMR_S 570 - Pathogénie des infections systémiques
2 UMR_S 570 - Pathogénie des infections systémiques
3 UMR_S567 / UMR 8104 - Institut Cochin
4 Institut du Fer à Moulin
5 Weill Medical College of Cornell University [New York]
6 Department of Biological Sciences
Abstract : Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is required for bacteria to cross the blood-brain barrier. Here, type IV pili-mediated adhesion of N. meningitidis to human brain endothelial cells was found to recruit the Par3/Par6/PKCzeta polarity complex that plays a pivotal role in the establishment of eukaryotic cell polarity and the formation of intercellular junctions. This recruitment leads to the formation of ectopic intercellular junctional domains at the site of bacteria-host cell interaction and a subsequent depletion of junctional proteins at the cell-cell interface with opening of the intercellular junctions of the brain-endothelial interface.
Keywords : Neisseria meningitidis blood brain barrier endothelial cells meningitis
Type de document :
Article dans une revue
Science, American Association for the Advancement of Science, 2009, 325 (5936), pp.83-7. 〈10.1126/science.1173196〉
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Coureuil Mathieu, Guillain Mikaty, Florence Miller, Hervé Lécuyer, Christine Bernard, et al.. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.. Science, American Association for the Advancement of Science, 2009, 325 (5936), pp.83-7. 〈10.1126/science.1173196〉. 〈inserm-00767121〉

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