G. Lowe, Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease, Journal of Thrombosis and Haemostasis, vol.97, issue.8, pp.1618-1627, 2005.
DOI : 10.1191/1358863x04vm559oa

F. Castellino and V. Ploplis, The protein C pathway and pathologic processes, Journal of Thrombosis and Haemostasis, vol.29, pp.140-145, 2009.
DOI : 10.1111/j.1538-7836.2009.03410.x

M. Menschikowski, A. Hagelgans, and G. Eisenhofer, Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways, Experimental Cell Research, vol.315, issue.15, pp.2673-2682, 2009.
DOI : 10.1016/j.yexcr.2009.05.015

Z. Laszik, A. Mitro, F. Taylor, and . Jr, Human Protein C Receptor Is Present Primarily on Endothelium of Large Blood Vessels : Implications for the Control of the Protein C Pathway, Circulation, vol.96, issue.10, pp.3633-3640, 1997.
DOI : 10.1161/01.CIR.96.10.3633

X. Ye, K. Fukudome, and N. Tsuneyoshi, The Endothelial Cell Protein C Receptor (EPCR) Functions as a Primary Receptor for Protein C Activation on Endothelial Cells in Arteries, Veins, and Capillaries, Biochemical and Biophysical Research Communications, vol.259, issue.3, pp.671-677, 1999.
DOI : 10.1006/bbrc.1999.0846

C. Esmon, Structure and functions of the endothelial cell protein C receptor, Critical Care Medicine, vol.32, issue.Supplement, pp.298-301, 2004.
DOI : 10.1097/01.CCM.0000126128.64614.81

C. Esmon, The endothelial cell protein C receptor, Thromb Haemost, vol.83, pp.639-643, 2000.

T. Cheng, D. Liu, and J. Griffin, Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective, Nature Medicine, vol.9, issue.3, pp.338-342, 2003.
DOI : 10.1038/nm826

J. Xu, D. Qu, and N. Esmon, Metalloproteolytic Release of Endothelial Cell Protein C Receptor, Journal of Biological Chemistry, vol.275, issue.8, pp.6038-6044, 2000.
DOI : 10.1074/jbc.275.8.6038

D. Qu, Y. Wang, and N. Esmon, Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-?? converting enzyme/ADAM17, Journal of Thrombosis and Haemostasis, vol.274, issue.2, pp.395-402, 2007.
DOI : 10.1111/j.1538-7836.2007.02347.x

P. Liaw, P. Neuenschwander, and M. Smirnov, Mechanisms by Which Soluble Endothelial Cell Protein C Receptor Modulates Protein C and Activated Protein C Function, Journal of Biological Chemistry, vol.275, issue.8, pp.5447-5452, 2000.
DOI : 10.1074/jbc.275.8.5447

S. Kurosawa, C. Esmon, and D. Stearns-kurosawa, The Soluble Endothelial Protein C Receptor Binds to Activated Neutrophils: Involvement of Proteinase-3 and CD11b/CD18, The Journal of Immunology, vol.165, issue.8, pp.4697-4703, 2000.
DOI : 10.4049/jimmunol.165.8.4697

D. Stearns-kurosawa, K. Swindle, D. Angelo, and A. , Plasma levels of endothelial protein C receptor respond to anticoagulant treatment, Blood, vol.99, issue.2, pp.526-530, 2002.
DOI : 10.1182/blood.V99.2.526

J. Lopez-sagaseta, R. Montes, and C. Puy, Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity, Journal of Thrombosis and Haemostasis, vol.267, issue.9, pp.1817-1824, 2007.
DOI : 10.1111/j.1538-7836.2007.02648.x

S. Kurosawa, D. Stearns-kurosawa, and C. Carson, Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes, Blood, vol.91, pp.725-727, 1998.

U. De-willige, S. Van-marion, V. Rosendaal, and F. , Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosis, Journal of Thrombosis and Haemostasis, vol.95, issue.8, pp.1305-1310, 2004.
DOI : 10.1016/S0140-6736(94)90286-0

P. Medina, S. Navarro, and J. Corral, Endothelial protein C receptor polymorphisms and risk of myocardial infarction, Haematologica, vol.93, issue.9, pp.1358-1363, 2008.
DOI : 10.3324/haematol.13066

H. Ireland, J. Cooper, and F. Drenos, FVII, FVIIa, and Downstream Markers of Extrinsic Pathway Activation Differ by EPCR Ser219Gly Variant in Healthy Men, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.29, issue.11, pp.1968-1974, 2009.
DOI : 10.1161/ATVBAHA.109.191551

P. Medina, S. Navarro, and A. Estelles, Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor, circulating activated protein C levels and thrombotic risk, Thrombosis and Haemostasis, vol.91, pp.905-911, 2004.
DOI : 10.1160/TH03-10-0657

B. Saposnik, J. Reny, and P. Gaussem, A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis, Blood, vol.103, issue.4, pp.1311-1318, 2004.
DOI : 10.1182/blood-2003-07-2520

K. Yamagishi, M. Cushman, and S. Heckbert, 6936A/G polymorphism with the risk of venous thromboembolism in a prospective study, British Journal of Haematology, vol.24, issue.2, pp.221-226, 2009.
DOI : 10.1111/j.1365-2141.2009.07612.x

H. Ireland, C. Konstantoulas, and J. Cooper, EPCR Ser219Gly: Elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro, Atherosclerosis, vol.183, issue.2, pp.283-292, 2005.
DOI : 10.1016/j.atherosclerosis.2005.02.028

D. Qu, Y. Wang, Y. Song, N. Esmon, and C. Esmon, The Ser219->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype, Journal of Thrombosis and Haemostasis, vol.263, issue.1, pp.229-235, 2006.
DOI : 10.1182/blood-2004-03-1203

B. Saposnik, E. Lesteven, A. Lokajczyk, C. Esmon, M. Aiach et al., Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma, Blood, vol.111, issue.7, pp.3442-5126, 2008.
DOI : 10.1182/blood-2007-08-104968

H. Rupprecht, S. Blankenberg, and C. Bickel, Impact of Viral and Bacterial Infectious Burden on Long-Term Prognosis in Patients With Coronary Artery Disease, Circulation, vol.104, issue.1, pp.25-31, 2001.
DOI : 10.1161/hc2601.091703

D. Tregouet, R. Schnabel, and M. Alessi, study, Journal of Thrombosis and Haemostasis, vol.111, issue.1, pp.49-57, 2009.
DOI : 10.1111/j.1538-7836.2008.03221.x
URL : https://hal.archives-ouvertes.fr/hal-01116056

P. Wild, T. Zeller, and A. Schillert, A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease, Circulation: Cardiovascular Genetics, vol.4, issue.4, pp.403-412, 2011.
DOI : 10.1161/CIRCGENETICS.110.958728

P. Sasieni, From Genotypes to Genes: Doubling the Sample Size, Biometrics, vol.53, issue.4, pp.1253-1261, 1997.
DOI : 10.2307/2533494

D. Trégouët and V. Garelle, A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies, Bioinformatics, vol.23, issue.8, pp.1038-1039, 2007.
DOI : 10.1093/bioinformatics/btm058

C. Guitton, N. Gerard, and T. Quillard, Circulating Endothelial Cell Protein C Receptor: Endothelial Regulation and Cumulative Impact of Gender and A3 Haplotype, Journal of Vascular Research, vol.48, issue.4, pp.336-346, 2011.
DOI : 10.1159/000322582

J. Dennis, C. Johnson, A. Adediran, M. De-andrade, J. Heit et al., The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies, Blood, vol.119, issue.10, pp.2392-2400, 2012.
DOI : 10.1182/blood-2011-10-383448

P. Morange, S. Blankenberg, and M. Alessi, Prognostic value of plasma tissue factor and tissue factor pathway inhibitor for cardiovascular death in patients with coronary artery disease: the AtheroGene study, Journal of Thrombosis and Haemostasis, vol.27, issue.3, pp.475-482, 2007.
DOI : 10.1111/j.1538-7836.2007.02372.x

V. Bogdanov, V. Balasubramanian, and J. Hathcock, Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein, Nature Medicine, vol.9, issue.4, pp.458-462, 2003.
DOI : 10.1038/nm841

P. Sen, R. Gopalakrishnan, and H. Kothari, Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection, Blood, vol.117, issue.11, pp.3199-3208, 2011.
DOI : 10.1182/blood-2010-09-310706

J. Gu, Y. Katsuura, G. Ferrell, P. Grammas, and C. Esmon, Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo, Blood, vol.95, pp.1687-1693, 2000.

K. Keven, S. Elmaci, and S. Sengul, Soluble endothelial cell protein C receptor and thrombomodulin levels after renal transplantation, International Urology and Nephrology, vol.3, issue.4, pp.1093-1098, 2010.
DOI : 10.1007/s11255-009-9654-6

L. Bash, T. Erlinger, and J. Coresh, Inflammation, Hemostasis, and the Risk of Kidney Function Decline in the Atherosclerosis Risk in Communities (ARIC) Study, American Journal of Kidney Diseases, vol.53, issue.4, pp.596-605, 2009.
DOI : 10.1053/j.ajkd.2008.10.044