Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The AtheroGene Study.

Choumous Kallel 1 William Cohen 1 Noémie Saut 1 Stefan Blankenberg 2 Renate Schnabel 2 Hans Rupprecht 3 Christoph Bickel 4 Thomas Munzel 3 David-Alexandre Tregouet 5 Pierre-Emmanuel Morange 1, *
* Auteur correspondant
1 NORT - Nutrition, obésité et risque thrombotique
2 Department of General and Interventional Cardiology
3 Department of Medicine II
4 Federal Armed Forces Central Hospital Koblenz
5 Génomique cardiovasculaire
Abstract : ABSTRACT: BACKGROUND: Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE). METHODS: We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant. RESULTS: At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68) . The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10 -200) but did not associate with CVE risk. CONCLUSION: Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
Keywords : Haemostasis Protein C Endothelial protein C receptor Coronary artery disease
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BMC Medical Genetics, BioMed Central, 2012, 13 (1), pp.103. 〈10.1186/1471-2350-13-103〉
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Choumous Kallel, William Cohen, Noémie Saut, Stefan Blankenberg, Renate Schnabel, et al.. Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: The AtheroGene Study.. BMC Medical Genetics, BioMed Central, 2012, 13 (1), pp.103. 〈10.1186/1471-2350-13-103〉. 〈inserm-00765626〉

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