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Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: potential implications.

Abstract : UNLABELLED: ABSTRACT: BACKGROUND: Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB. METHODS: We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB. RESULTS: Our main finding was that CPB-induced coagulopathy was differently appreciated depending on the presence or absence of platelets: the decrease in thrombin generation was much less pronounced in their presence (mean endogenous thrombin potential change values before and after CPB were -3.9% in the presence of platelets and -39.6% in their absence). CONCLUSION: Our results show that experimental conditions have a profound effect in the study of in vitro thrombin generation in the context of CPB.
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Submitted on : Friday, December 14, 2012 - 9:05:20 PM
Last modification on : Friday, February 9, 2018 - 4:42:06 PM
Long-term archiving on: : Friday, March 15, 2013 - 3:53:23 AM

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Rose Said, Véronique Regnault, Marie Hacquard, Jean-Pierre Carteaux, Thomas Lecompte. Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: potential implications.. Thrombosis Journal, BioMed Central, 2012, 10 (1), pp.15. ⟨10.1186/1477-9560-10-15⟩. ⟨inserm-00765579⟩

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