AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.

Stéphane Peineau 1 Brigitte Potier 1 Florence Petit 1 Pascal Dournaud 1 Jacques Epelbaum 1 Robert Gardette 1, *
* Auteur correspondant
1 Neurobiologie de la Croissance et de la Senescence
Abstract : Modulation of glutamatergic transmission by neuropeptides is an essential aspect of neuronal network activity. Activation of the hypothalamic somatostatin sst2 receptor subtype by octreotide decreases AMPA glutamate responses, indicating a central link between a neurohormonal and neuromodulatory peptide and the main hypothalamic fast excitatory neurotransmitter. In mediobasal hypothalamic slices, sst2 activation inhibits the AMPA component of glutamatergic synaptic responses but is ineffective when AMPA currents are pharmacologically isolated. In mediobasal hypothalamic cultures, the decrease of AMPA currents induced by octreotide requires a concomitant activation of sst2 receptors with either NMDA and/or metabotropic glutamate receptors. This modulation depends on changes in intracellular calcium concentration induced by calcium flux through NMDA receptors or calcium release from intracellular stores following metabotropic glutamate receptor activation. These results highlight an unusual regulatory mechanism in which the simultaneous activation of at least three different types of receptor is necessary to allow somatostatin-induced modulation of fast synaptic glutamatergic transmission in the hypothalamus.
Type de document :
Article dans une revue
Journal of Physiology, Wiley, 2003, 546 (Pt 1), pp.101-17
Liste complète des métadonnées

Littérature citée [65 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00765213
Contributeur : Stephane Peineau <>
Soumis le : vendredi 14 décembre 2012 - 12:08:39
Dernière modification le : jeudi 11 janvier 2018 - 06:20:15
Document(s) archivé(s) le : vendredi 15 mars 2013 - 03:47:11

Fichier

2003_-_J_Physiol_-_Peineau_et_...
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : inserm-00765213, version 1
  • PUBMED : 12509482

Collections

UNIV-PARIS5 | USPC

Citation

Stéphane Peineau, Brigitte Potier, Florence Petit, Pascal Dournaud, Jacques Epelbaum, et al.. AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.. Journal of Physiology, Wiley, 2003, 546 (Pt 1), pp.101-17. 〈inserm-00765213〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

157

Téléchargements de fichiers

201

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD