Skip to Main content Skip to Navigation
Journal articles

AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.

Abstract : Modulation of glutamatergic transmission by neuropeptides is an essential aspect of neuronal network activity. Activation of the hypothalamic somatostatin sst2 receptor subtype by octreotide decreases AMPA glutamate responses, indicating a central link between a neurohormonal and neuromodulatory peptide and the main hypothalamic fast excitatory neurotransmitter. In mediobasal hypothalamic slices, sst2 activation inhibits the AMPA component of glutamatergic synaptic responses but is ineffective when AMPA currents are pharmacologically isolated. In mediobasal hypothalamic cultures, the decrease of AMPA currents induced by octreotide requires a concomitant activation of sst2 receptors with either NMDA and/or metabotropic glutamate receptors. This modulation depends on changes in intracellular calcium concentration induced by calcium flux through NMDA receptors or calcium release from intracellular stores following metabotropic glutamate receptor activation. These results highlight an unusual regulatory mechanism in which the simultaneous activation of at least three different types of receptor is necessary to allow somatostatin-induced modulation of fast synaptic glutamatergic transmission in the hypothalamus.
Document type :
Journal articles
Complete list of metadatas

Cited literature [65 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00765213
Contributor : Stephane Peineau <>
Submitted on : Friday, December 14, 2012 - 12:08:39 PM
Last modification on : Saturday, November 21, 2020 - 3:46:02 PM
Long-term archiving on: : Friday, March 15, 2013 - 3:47:11 AM

File

2003_-_J_Physiol_-_Peineau_et_...
Files produced by the author(s)

Identifiers

  • HAL Id : inserm-00765213, version 1
  • PUBMED : 12509482

Collections

Citation

Stéphane Peineau, Brigitte Potier, Florence Petit, Pascal Dournaud, Jacques Epelbaum, et al.. AMPA-sst2 somatostatin receptor interaction in rat hypothalamus requires activation of NMDA and/or metabotropic glutamate receptors and depends on intracellular calcium.. The Journal of Physiology, Wiley, 2003, 546 (Pt 1), pp.101-17. ⟨inserm-00765213⟩

Share

Metrics

Record views

304

Files downloads

555