Skip to Main content Skip to Navigation
Journal articles

Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study.

Abstract : ABSTRACT: BACKGROUND: As discontinuation in in vitro fertilization (IVF) programs has been associated with a poor prognosis, one hypothesis is that some couple-specific predictive factors in IVF may be shared with opposite effect by both successful (i.e. live birth) and treatment discontinuation processes. Our objective was to perform a joint analysis of these two processes to examine the hypothesis of a link between the two processes. METHODS: Analyses were conducted on a retrospective cohort of 3,002 women who began IVF between 1998 and 2002 in two French IVF centers: a Parisian center and a center in a medium-sized city in central France. A shared random effects model based on a joint modelization of IVF treatment success and discontinuation was used to study the link between the two processes. RESULTS: Success and discontinuation processes were significantly linked in the medium-sized city center, whereas they were not linked in the Parisian center. The center influenced risk of treatment discontinuation but not chance of success. The well-known inverse-J relation between the woman's age and chance of success was observed, as expected. Risk of discontinuation globally increased as the woman's age increased. CONCLUSIONS: The link between success and discontinuation processes could depend on the fertility center. In particular, the woman's decision to pursue or to discontinue IVF in a particular center could depend on the presence of other IVF centers in the surrounding area.
Document type :
Journal articles
Complete list of metadata

Cited literature [32 references]  Display  Hide  Download
Contributor : Ed. Bmc Connect in order to contact the contributor
Submitted on : Tuesday, December 4, 2012 - 1:07:10 AM
Last modification on : Wednesday, October 20, 2021 - 12:24:15 AM
Long-term archiving on: : Tuesday, March 5, 2013 - 3:50:05 AM




Pénélope Troude, Sophie Ancelet, Juliette Guibert, Jean-Luc Pouly, Jean Bouyer, et al.. Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study.. BMC Pregnancy and Childbirth, BioMed Central, 2012, 12 (1), pp.77. ⟨10.1186/1471-2393-12-77⟩. ⟨inserm-00760462⟩



Record views


Files downloads