Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.

Laure Bobyk; Magali Edouard; Pierre Deman; Julia Rousseau; Jean-François Adam; Jean-Luc Ravanat; François Estève; Jacques Balosso; Rolf Barth; Hélène Elleaume

doi:10.1186/1756-9966-31-78

Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.

Laure Bobyk ^{1, 2, 3} Magali Edouard ^{2, 3} Pierre Deman ^{2, 3} Julia Rousseau ^{2, 3} Jean-François Adam ^{2, 3} Jean-Luc Ravanat ¹ François Estève ^{2, 3} Jacques Balosso ^{2, 3} Rolf Barth ⁴ Hélène Elleaume ^{2, 3, *}

* Auteur correspondant

1 LAN - Laboratoire Lésions des Acides Nucléiques

SCIB - UMR E3 - Service de Chimie Inorganique et Biologique : DSM/INAC/SCIB

2 ID17 - Bio-medical Beamline

3 GIN - Grenoble Institut des Neurosciences

4 Department of Pathology

Abstract : ABSTRACT: BACKGROUND: The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats. METHODS: Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays. RESULTS: Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons. CONCLUSIONS: These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.

Keywords : F98 rat glioma Carboplatin Osmotic pumps Intracerebral delivery Radiotherapy with 6 MV photons or synchrotron X-rays

Type de document :

Article dans une revue

Journal of Experimental and Clinical Cancer Research, BioMed Central, 2012, 31 (1), pp.78. 〈10.1186/1756-9966-31-78〉

Domaine :

Sciences du Vivant [q-bio] / Cancer

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Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.

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Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.

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