 |
Journal articles
Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma.
Abstract : ABSTRACT: BACKGROUND: The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats. METHODS: Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using AlzetTM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays. RESULTS: Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons. CONCLUSIONS: These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.
Cited literature [39 references]
https://www.hal.inserm.fr/inserm-00759750
Contributor : Ed. Bmc <>
Submitted on : Sunday, December 2, 2012 - 5:07:11 PM
Last modification on : Friday, July 10, 2020 - 7:58:44 AM
Long-term archiving on: : Sunday, March 3, 2013 - 3:43:01 AM
Contributor : Ed. Bmc <>
Submitted on : Sunday, December 2, 2012 - 5:07:11 PM
Last modification on : Friday, July 10, 2020 - 7:58:44 AM
Long-term archiving on: : Sunday, March 3, 2013 - 3:43:01 AM