Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors.

Xiao Tong 1 Anikitos Garofalakis 1 Albertine Dubois 1 Raphaël Boisgard 1 Frédéric Ducongé 1 Régine Trébossen 1 Bertrand Tavitian 1, *
* Auteur correspondant
1 IMIV - U1023 - ERL9218 - Imagerie Moléculaire In Vivo
Abstract : ABSTRACT: BACKGROUND: Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of the present study is to co-register fDOT and PET molecular images of tumors in mice automatically. METHODS: The coordinates of bimodal fiducial markers (FM) in regions of detection were automatically detected in planar optical images (x, y positions) in laser pattern optical surface images (z position) and in 3-D PET images. A transformation matrix was calculated from the coordinates of the FM in fDOT and in PET and applied in order to co-register images of mice bearing neuroendocrine tumors. RESULTS: The method yielded accurate non-supervised co-registration of fDOT and PET images. The mean fiducial registration error was smaller than the respective voxel sizes for both modalities, allowing comparison of the distribution of contrast agents from both modalities in mice. Combined imaging depicting tumor metabolism with PET-[18 F]2-deoxy-2-fluoro-D-glucose and blood pool with fDOT demonstrated partial overlap of the two signals. CONCLUSIONS: This automatic method for co-registration of fDOT with PET and other modalities is efficient, simple and rapid, opening up multiplexing capacities for experimental in vivo molecular imaging.
Keywords : Co-registration fDOT PET Fiducial marker detection Optical surface image Neuroendocrine tumors MEN2A
Type de document :
Article dans une revue
EJNMMI Research, BioMed Central, 2012, 2 (1), pp.19. 〈10.1186/2191-219X-2-19〉
Liste complète des métadonnées

Littérature citée [33 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00757432
Contributeur : Ed. Bmc <>
Soumis le : lundi 26 novembre 2012 - 21:07:21
Dernière modification le : mercredi 26 septembre 2018 - 01:00:33
Document(s) archivé(s) le : mercredi 27 février 2013 - 03:48:15

Fichiers

2191-219X-2-19.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

CEA | JOLIOT | CEA-DRF | SHFJ

Citation

Xiao Tong, Anikitos Garofalakis, Albertine Dubois, Raphaël Boisgard, Frédéric Ducongé, et al.. Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors.. EJNMMI Research, BioMed Central, 2012, 2 (1), pp.19. 〈10.1186/2191-219X-2-19〉. 〈inserm-00757432〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

291

Téléchargements de fichiers

302

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD