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Depot-specific regulation of autotaxin with obesity in human adipose tissue.

Abstract : Autotaxin (ATX) is a lysophospholipase D involved in synthesis of a bioactive mediator: lysophosphatidic. ATX is abundantly produced by adipocytes and exerts a negative action on adipose tissue expansion. In both mice and humans, ATX expression increases with obesity in association with insulin resistance. In the present study, fat depot-specific regulation of ATX was explored in human. ATX mRNA expression was quantified in visceral and subcutaneous adipose tissue in obese (BMI > 40 kg/m(2); n = 27) and non-obese patients (BMI < 25 kg/m(2); n = 10). Whatever the weight status of the patients is, ATX expression was always higher (1.3- to 6-fold) in subcutaneous than in visceral fat. Nevertheless, visceral fat ATX was significantly higher (42 %) in obese than in non-obese patients, whereas subcutaneous fat ATX remained unchanged. In obese patients, visceral fat ATX expression was positively correlated with diastolic arterial blood pressure (r = 0.67; P = 0.001). This correlation was not observed with subcutaneous fat ATX. Visceral fat ATX was mainly correlated with leptin (r = 0.60; P = 0.001), inducible nitric oxide synthase (r = 0.58; P = 0,007), and apelin receptor (r = 0.50; P = 0.007). These correlations were not observed with subcutaneous fat ATX. These results reveal that obesity-associated upregulation of human adipose tissue ATX is specific to the visceral fat depot.
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Contributor : Marie Francoise Simon Connect in order to contact the contributor
Submitted on : Friday, November 23, 2012 - 1:38:50 PM
Last modification on : Monday, July 4, 2022 - 9:24:53 AM



Chloé Rancoule, Rodolphe Dusaulcy, Karine Tréguer, Sandra Grès, Charlotte Guigné, et al.. Depot-specific regulation of autotaxin with obesity in human adipose tissue.. Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2012, 68 (4), pp.635-44. ⟨10.1007/s13105-012-0181-z⟩. ⟨inserm-00756630⟩



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