Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.

Joanna Ivars 1 Laura Butruille 1 Claude Knauf 2 Thomas Bouckenooghe 1 Sylvain Mayeur 1 Didier Vieau 1 Philippe Valet 2 Philippe Deruelle 1 Jean Lesage 1, *
* Auteur correspondant
1 Department of Orthopaedics, Tissue Bank, Geriatrics
2 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
Abstract : Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/APJ system in fetal tissues and placenta. At term, plasma levels of apelin were not modulated but APJ expression was increased in placenta and lung but reduced in heart. Apelin expression was increased only in the heart. We postulate that the apelinergic system may control fetal growth and cardiovascular functions in utero.
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Article dans une revue
Peptides, Elsevier, 2012, 35 (1), pp.136-8. 〈10.1016/j.peptides.2012.03.005〉
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http://www.hal.inserm.fr/inserm-00756533
Contributeur : Marie Francoise Simon <>
Soumis le : vendredi 23 novembre 2012 - 11:16:00
Dernière modification le : jeudi 4 octobre 2018 - 09:50:10

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Joanna Ivars, Laura Butruille, Claude Knauf, Thomas Bouckenooghe, Sylvain Mayeur, et al.. Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.. Peptides, Elsevier, 2012, 35 (1), pp.136-8. 〈10.1016/j.peptides.2012.03.005〉. 〈inserm-00756533〉

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