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[Normobaric hyperoxia therapy for patients with traumatic brain injury].

Gilles Francony 1 Pierre Bouzat 1 Julien Picard 2 Marie-Cécile Fevre 2 Samuel Gay 1 Jean-François Payen 1, * 
* Corresponding author
1 ANTE-INSERM U836, équipe 5, Neuroimagerie fonctionnelle et perfusion cérébrale
GIN - Grenoble Institut des Neurosciences, Service d'anesthésie-réanimation
Abstract : Cerebral ischaemia plays a major role in the outcome of brain-injured patients. Because brain oxygenation can be assessed at bedside using intra-parenchymal devices, there has been a growing interest about whether therapeutic hyperoxia could be beneficial for severely head-injured patients. Normobaric hyperoxia increases brain oxygenation and may improve glucose-lactate metabolism in brain regions at risk for ischaemia. However, benefits of normobaric hyperoxia on neurological outcome are not established yet, that hinders the systematic use of therapeutic hyperoxia in head-injured patients. This therapeutic option might be proposed when brain ischemia persists despite the optimization of cerebral blood flow and arterial oxygen blood content.
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Submitted on : Tuesday, November 20, 2012 - 10:45:54 AM
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Gilles Francony, Pierre Bouzat, Julien Picard, Marie-Cécile Fevre, Samuel Gay, et al.. [Normobaric hyperoxia therapy for patients with traumatic brain injury].. Annales Françaises d'Anesthésie et de Réanimation, Elsevier Masson, 2012, 31 (3), pp.224-7. ⟨10.1016/j.annfar.2011.11.009⟩. ⟨inserm-00754948⟩



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