D. Smith, D. Malone, K. Lawson, L. Okamoto, C. Battista et al., A National Estimate of the Economic Costs of Asthma, American Journal of Respiratory and Critical Care Medicine, vol.156, issue.3, pp.787-93, 1997.
DOI : 10.1164/ajrccm.156.3.9611072

D. Duffy, N. Martin, D. Battistutta, J. Hopper, and J. Mathews, Genetics of Asthma and Hay Fever in Australian Twins, American Review of Respiratory Disease, vol.142, issue.6_pt_1, pp.1351-1359, 1990.
DOI : 10.1164/ajrccm/142.6_Pt_1.1351

A. Kay, Allergy and allergic diseases. First of two parts, N Engl J Med, vol.344, issue.1, pp.30-37, 2001.

G. Weinmayr, S. Weiland, B. Bjorksten, B. Brunekreef, G. Buchele et al., Atopic Sensitization and the International Variation of Asthma Symptom Prevalence in Children, American Journal of Respiratory and Critical Care Medicine, vol.176, issue.6, pp.565-74, 2007.
DOI : 10.1164/rccm.200607-994OC

URL : https://hal.archives-ouvertes.fr/hal-00596400

W. Trust and C. C. Consortium, Genome-­?wide association study of 14,000 cases of seven common diseases and 3,000 shared controls, Nature, vol.447, issue.7145, pp.661-78, 2007.

M. Moffatt, M. Kabesch, L. Liang, A. Dixon, D. Strachan et al., Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma, Nature, vol.16, issue.7152, pp.470-473, 2007.
DOI : 10.1038/nature06014

E. Bouzigon, E. Corda, H. Aschard, M. Dizier, A. Boland et al., Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness, Nature, vol.418, issue.6896, pp.426-456, 2002.

Y. Zhang, N. Leaves, G. Anderson, C. Ponting, J. Broxholme et al., Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma, Nature Genetics, vol.34, issue.2, pp.181-187, 2003.
DOI : 10.1038/ng0904-931

J. White, M. Chiano, M. Wigglesworth, R. Geske, R. J. White et al., Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation, Human Molecular Genetics, vol.17, issue.13, pp.1890-903, 2008.
DOI : 10.1093/hmg/ddn087

L. Balaci, M. Spada, N. Olla, G. Sole, L. Loddo et al., IRAK-M Is Involved in the Pathogenesis of Early-Onset Persistent Asthma, The American Journal of Human Genetics, vol.80, issue.6, pp.1103-1117, 2007.
DOI : 10.1086/518259

E. Bleecker and D. Postma, Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness, Am J Respir Crit Care Med, vol.180, issue.10, pp.929-964, 2009.

P. Sleiman, F. J. Imielinski, M. Bradfield, J. Annaiah, K. Willis-­?owen et al., Associated with Asthma in Children, New England Journal of Medicine, vol.362, issue.1, pp.36-44
DOI : 10.1056/NEJMoa0901867

M. Jarvelin, C. Jackson, M. Kahonen, J. Kaprio, N. Probst-­?hensch et al., Genome-­?wide association study identifies five loci associated with lung function, Nat Genet, vol.42, issue.1, pp.36-44

W. Cookson, L. Liang, G. Abecasis, M. Moffatt, and M. Lathrop, Mapping complex disease traits with global gene expression, Nature Reviews Genetics, vol.103, issue.3, pp.184-94, 2009.
DOI : 10.1038/nrg2537

D. Verlaan, S. Berlivet, G. Hunninghake, A. Madore, M. Lariviere et al., Allele-Specific Chromatin Remodeling in the ZPBP2/GSDMB/ORMDL3 Locus Associated with the Risk of Asthma and Autoimmune Disease, The American Journal of Human Genetics, vol.85, issue.3, pp.377-93, 2009.
DOI : 10.1016/j.ajhg.2009.08.007

D. Breslow, S. Collins, B. Bodenmiller, R. Aebersold, K. Simons et al., Orm family proteins mediate sphingolipid homeostasis, Nature, vol.23, issue.7284, pp.1048-53
DOI : 10.1038/nature08787

G. Nixon, Sphingolipids in inflammation: pathological implications and potential therapeutic targets, British Journal of Pharmacology, vol.89, issue.4, pp.982-93, 2009.
DOI : 10.1111/j.1476-5381.2009.00281.x

D. Gudbjartsson, U. Bjornsdottir, E. Halapi, A. Helgadottir, P. Sulem et al., Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction, Nature Genetics, vol.447, issue.3, pp.342-349, 2009.
DOI : 10.1038/ng1245

J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy et al., IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines, Immunity, vol.23, issue.5, pp.479-90, 2005.
DOI : 10.1016/j.immuni.2005.09.015

V. Carriere, L. Roussel, N. Ortega, D. Lacorre, L. Americh et al., IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo, Proceedings of the National Academy of Sciences, vol.104, issue.1, pp.282-289, 2007.
DOI : 10.1073/pnas.0606854104

C. Moussion, N. Ortega, and J. Girard, The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ???Alarmin????, PLoS ONE, vol.106, issue.10, p.3331, 2008.
DOI : 10.1371/journal.pone.0003331.g006

T. Fukao, S. Matsuda, and S. Koyasu, Synergistic Effects of IL-4 and IL-18 on IL-12-Dependent IFN-?? Production by Dendritic Cells, The Journal of Immunology, vol.164, issue.1, pp.64-71, 2000.
DOI : 10.4049/jimmunol.164.1.64

K. Nouri-­?aria and S. Durham, Regulatory T Cells and Allergic Disease, Inflammation & Allergy-Drug Targets, vol.7, issue.4, pp.237-52, 2008.
DOI : 10.2174/187152808786848405

M. Anthoni, G. Wang, M. Leino, A. Lauerma, H. Alenius et al., Smad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse model of asthma, International Journal of Biological Sciences, vol.3, issue.7, pp.477-85, 2007.
DOI : 10.7150/ijbs.3.477

S. Letourneau, C. Krieg, G. Pantaleo, and O. Boyman, IL-2??? and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets, Journal of Allergy and Clinical Immunology, vol.123, issue.4, pp.758-62, 2009.
DOI : 10.1016/j.jaci.2009.02.011

D. Marsh, D. Meyers, and W. Bias, The Epidemiology and Genetics of Atopic Allergy, New England Journal of Medicine, vol.305, issue.26, pp.1551-1560, 1981.
DOI : 10.1056/NEJM198112243052603

D. Marsh, M. Blumenthal, and T. Ishikawa, HLA and specific immune respoinsiveness to allergens, Proceedings of the eleventh international histocompatability workshop and conference, pp.765-772, 1992.

M. Moffatt, C. Schou, J. Faux, G. Abecasis, A. James et al., Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample, European Journal of Human Genetics, vol.9, issue.5, pp.341-347, 2001.
DOI : 10.1038/sj.ejhg.5200636

M. Moffatt and W. Cookson, Tumour necrosis factor haplotypes and asthma, Human Molecular Genetics, vol.6, issue.4, pp.551-555, 1997.
DOI : 10.1093/hmg/6.4.551

J. Barrett, S. Hansoul, D. Nicolae, J. Cho, R. Duerr et al., Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nature Genetics, vol.179, issue.8, pp.955-62, 2008.
DOI : 10.1021/bi060570x

J. Taylor, T. Street, L. Hao, R. Copley, M. Taylor et al., Dynamic and Physical Clustering of Gene Expression during Epidermal Barrier Formation in Differentiating Keratinocytes, PLoS ONE, vol.33, issue.10, p.7651, 2009.
DOI : 10.1371/journal.pone.0007651.s008

A. Walley, S. Chavanas, M. Moffatt, R. Esnouf, B. Ubhi et al., Gene polymorphism in Netherton and common atopic disease, Nature Genetics, vol.29, issue.2, pp.175-183, 2001.
DOI : 10.1038/ng728

D. Vercelli, Advances in asthma and allergy genetics in 2007, Journal of Allergy and Clinical Immunology, vol.122, issue.2, pp.267-71, 2008.
DOI : 10.1016/j.jaci.2008.06.008

F. Dudbridge and A. Gusnanto, Estimation of significance thresholds for genomewide association scans, Genetic Epidemiology, vol.447, issue.3, pp.227-261, 2008.
DOI : 10.1002/gepi.20297

F. Med, M. W. Sci, and M. D. Gerbase, Lee-­?Jane S GABRIEL genome-­?wide association study for asthma 38, Ph.D. 33,58 , Ivan Curjuric, M.D. 30, p.6161616465

M. D. Koppelman and . D. Ph, Aristea Binia, M.Sc. 1,101

. Génotypage, Fondation Jean-­?Dausset-­? Centre d'Etude du Polymorphisme Humain (CEPH)

P. Service, G. Hospital, . Galdakao, . Bizkaia, and . Spain, 38 Servicio de Neumología, GABRIEL genome-­?wide association study for asthma 41

R. &. Glaxosmithkline, . Research-triangle, . Park, . Nc, and N. Usa, 48 Genetics of Asthma International Network (GAIN) Investigator. 49 University of Aberdeen, Royal Aberdeen Children's Hospital, Aberdeen, UK. 50 Department of Paediatrics, Oslo University Hospital and Faculty of Medicine 51 Beatrix Children's Hospital, Greece. 55 Abt. Fuer Kinderheilkunde Foschungsinstitut zur Praevention von Allergien und Atemwegserkrankungen im Kindesalter

. Australia, 75 School of Population Health, University of Western Australia, Western Australia, p.76

C. Chicoutimi, 77 Université due Québec à Chicoutimi, p.78

B. Vancouver and C. , 84 Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health

. Winnipeg and C. Manitoba, 86 Division of Allergy, Department of Pediatrics, University of British Columbia, p.634050

R. Tomsk and . Federation, 88 TOMSK Study Investigator. 89 Department of Faculty Paediatrics, Siberian State Medical University, 634050 Tomsk, Russian Federation. 90 General Doctor Practice Department, p.91

N. Translational, R. Facility-in-respiratory-medicine, and U. Manchester, 103 Division of Human Genetics and Division of Infection, 105 Department of Biology Russian Federation. 106 KSMU Study Investigator. 107 Institute of Environmental Medicine

R. Astrazeneca and . Mölndal, 111 Sachs Children's Hospital

. Sweden, 112 Department of Biosciences and Nutrition, Karolinska Institutet, issue.113

T. Groningen and . Netherlands, 114 PIAMA Study Investigator

R. Hospital and . Netherlands, 118 Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment

F. Helsinki, 131 Department of Epidemiology and Public Health, Imperial College, London, UK. 132 University Children's Hospital, Asthma and Allergy Department