S. Huson, D. Compston, P. Clark, and P. Harper, A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity., Journal of Medical Genetics, vol.26, issue.11, pp.26704-711, 1989.
DOI : 10.1136/jmg.26.11.704

S. Rasmussen, Q. Yang, and J. Friedman, Mortality in Neurofibromatosis 1: An Analysis Using U.S. Death Certificates, The American Journal of Human Genetics, vol.68, issue.5, pp.1110-1118, 2001.
DOI : 10.1086/320121

T. Duong, E. Sbidian, L. Valeyrie-allanore, C. Vialette, S. Ferkal et al., Mortality Associated with Neurofibromatosis 1: A Cohort Study of 1895 Patients in 1980-2006 in France, Orphanet Journal of Rare Diseases, vol.6, issue.1, p.18, 1980.
DOI : 10.1093/neuonc/noq146
URL : https://hal.archives-ouvertes.fr/inserm-00593483

V. Riccardi, Neurofibromatosis, Plastic and Reconstructive Surgery, vol.91, issue.3, 1992.
DOI : 10.1097/00006534-199303000-00029
URL : https://hal.archives-ouvertes.fr/inserm-00748122

T. Tucker, V. Riccardi, C. Brown, J. Fee, M. Sutcliffe et al., S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas, Journal of Neuroscience Research, vol.296, issue.9, pp.1451-1460, 2011.
DOI : 10.1002/jnr.22654

T. Tucker, V. Riccardi, M. Sutcliffe, J. Vielkind, J. Wechsler et al., Different Patterns of Mast Cells Distinguish Diffuse from Encapsulated Neurofibromas in Patients with Neurofibromatosis 1, Journal of Histochemistry & Cytochemistry, vol.296, issue.6, pp.59584-590, 2011.
DOI : 10.1369/0022155411407340

T. Tucker, P. Wolkenstein, J. Revuz, J. Zeller, and J. Friedman, Association between benign and malignant peripheral nerve sheath tumors in NF1, Neurology, vol.65, issue.2, pp.205-211, 2005.
DOI : 10.1212/01.wnl.0000168830.79997.13

D. Evans, M. Baser, J. Mcgaughran, S. Sharif, E. Howard et al., Malignant peripheral nerve sheath tumours in neurofibromatosis 1, Journal of Medical Genetics, vol.39, issue.5, pp.311-314, 2002.
DOI : 10.1136/jmg.39.5.311

L. Valeyrie-allanore, N. Ismaili, S. Bastuji-garin, J. Zeller, J. Wechsler et al., Symptoms associated with malignancy of peripheral nerve sheath tumours: a retrospective study of 69 patients with neurofibromatosis 1, British Journal of Dermatology, vol.12, issue.1
DOI : 10.1038/ng0293-122

S. Pinson, A. Creange, S. Barbarot, J. Stalder, Y. Chaix et al., Neurofibromatosis 1: recommendations for management, Ann Dermatol Venereol, vol.128, issue.4, pp.567-575, 2001.

D. Gutmann, A. Aylsworth, J. Carey, B. Korf, J. Marks et al., The Diagnostic Evaluation and Multidisciplinary Management of Neurofibromatosis 1 and Neurofibromatosis 2, JAMA: The Journal of the American Medical Association, vol.278, issue.1, pp.51-57, 1997.
DOI : 10.1001/jama.1997.03550010065042

C. Hagel, U. Zils, M. Peiper, L. Kluwe, S. Gotthard et al., Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors, Journal of Neuro-Oncology, vol.93, issue.2, pp.187-192, 2007.
DOI : 10.1007/s11060-006-9266-2

R. Friedrich, M. Hartmann, and V. Mautner, Malignant peripheral nerve sheath tumors (MPNST) in NF1-affected children, Anticancer Res, vol.27, issue.4A, pp.1957-1960, 2007.

J. Mccaughan, S. Holloway, R. Davidson, and W. Lam, Further evidence of the increased risk for malignant peripheral nerve sheath tumour from a Scottish cohort of patients with neurofibromatosis type 1, Journal of Medical Genetics, vol.44, issue.7, pp.44463-466, 2007.
DOI : 10.1136/jmg.2006.048140

E. Dombi, J. Solomon, A. Gillespie, E. Fox, F. Balis et al., NF1 plexiform neurofibroma growth rate by volumetric MRI: Relationship to age and body weight, Neurology, vol.68, issue.9, pp.643-647, 2007.
DOI : 10.1212/01.wnl.0000250332.89420.e6

E. Sbidian, P. Wolkenstein, L. Valeyrie-allanore, D. Rodriguez, S. Hadj-rabia et al., NF-1Score: A Prediction Score for Internal Neurofibromas in Neurofibromatosis-1, Journal of Investigative Dermatology, vol.130, issue.9, pp.2173-2178, 2010.
DOI : 10.1038/jid.2010.100

T. Duong, S. Bastuji-garin, L. Valeyrie-allanore, E. Sbidian, S. Ferkal et al., Evolving Pattern with Age of Cutaneous Signs in Neurofibromatosis Type 1: A Cross-Sectional Study of 728 Patients, Dermatology, vol.222, issue.3, pp.269-273, 2011.
DOI : 10.1159/000327379

P. Wolkenstein, B. Freche, J. Zeller, and J. Revuz, Usefulness of screening investigations in neurofibromatosis type 1. A study of 152 patients, Archives of Dermatology, vol.132, issue.11, pp.1333-1336, 1996.
DOI : 10.1001/archderm.132.11.1333

A. Sabbagh, E. Pasmant, I. Laurendeau, B. Parfait, S. Barbarot et al., Unravelling the genetic basis of variable clinical expression in neurofibromatosis 1, Human Molecular Genetics, vol.18, issue.15, pp.2768-2778, 2009.
DOI : 10.1093/hmg/ddp212

K. Khosrotehrani, S. Bastuji-garin, V. Riccardi, P. Birch, J. Friedman et al., Subcutaneous neurofibromas are associated with mortality in neurofibromatosis 1: A cohort study of 703 patients, American Journal of Medical Genetics Part A, vol.79, issue.1, pp.49-53, 2005.
DOI : 10.1002/ajmg.a.30394

J. Sterne, I. White, J. Carlin, M. Spratt, P. Royston et al., Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls, BMJ, vol.338, issue.jun29 1, p.2393, 2009.
DOI : 10.1136/bmj.b2393

R. Schumacker and G. Marcoulides, Interaction and Nonlinear Effects in Structural Equation Modeling, 1998.

A. Kim, A. Gillespie, E. Dombi, A. Goodwin, W. Goodspeed et al., Characteristics of children enrolled in treatment trials for NF1-related plexiform neurofibromas, Neurology, vol.73, issue.16, pp.731273-1279, 2009.
DOI : 10.1212/WNL.0b013e3181bd1326

K. Debella, J. Szudek, and J. Friedman, Use of the National Institutes of Health Criteria for Diagnosis of Neurofibromatosis 1 in Children, PEDIATRICS, vol.105, issue.3, pp.608-614, 2000.
DOI : 10.1542/peds.105.3.608

M. Cnossen, A. De-goede-bolder, K. Van-den-broek, C. Waasdorp, A. Oranje et al., A prospective 10??year follow up study of patients with neurofibromatosis type 1, Archives of Disease in Childhood, vol.78, issue.5, pp.78408-412, 1998.
DOI : 10.1136/adc.78.5.408

F. Harrell, . Jr, K. Lee, and D. Mark, MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS, Statistics in Medicine, vol.15, issue.4, pp.361-387, 1996.
DOI : 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4

P. Khong, W. Goh, V. Wong, C. Fung, and G. Ooi, MR Imaging of Spinal Tumors in Children with Neurofibromatosis 1, American Journal of Roentgenology, vol.180, issue.2, pp.413-417, 2003.
DOI : 10.2214/ajr.180.2.1800413

T. Tucker, J. Friedman, R. Friedrich, R. Wenzel, C. Funsterer et al., Longitudinal study of neurofibromatosis 1 associated plexiform neurofibromas, Journal of Medical Genetics, vol.46, issue.2, pp.81-85, 2009.
DOI : 10.1136/jmg.2008.061051

A. Overdiek, U. Winner, E. Mayatepek, and T. Rosenbaum, Schwann Cells From Human Neurofibromas Show Increased Proliferation Rates Under the Influence of Progesterone, Pediatric Research, vol.5, issue.1, pp.40-43, 2008.
DOI : 10.1203/PDR.0b013e31817445b8

H. Li, X. Zhang, L. Fishbein, F. Kweh, M. Campbell-thompson et al., Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells, Cancer Biology & Therapy, vol.52, issue.8, pp.10758-764, 2010.
DOI : 10.1158/1078-0432.CCR-09-1107

E. Sbidian, S. Bastuji-garin, L. Valeyrie-allanore, S. Ferkal, J. Lefaucheur et al., At-Risk Phenotype of Neurofibromatose-1 Patients: A Multicentre Case-Control Study, Orphanet Journal of Rare Diseases, vol.6, issue.1, p.51, 2011.
DOI : 10.1002/(SICI)1096-8628(19970516)70:2<138::AID-AJMG7>3.0.CO;2-U
URL : https://hal.archives-ouvertes.fr/inserm-00613196

K. Khosrotehrani, S. Bastuji-garin, J. Zeller, J. Revuz, and P. Wolkenstein, Clinical Risk Factors for Mortality in Patients With Neurofibromatosis 1, Archives of Dermatology, vol.139, issue.2, pp.187-191, 2003.
DOI : 10.1001/archderm.139.2.187

A. Zvulunov, Y. Barak, and A. Metzker, Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia. World statistical analysis, Archives of Dermatology, vol.131, issue.8, pp.131904-908, 1995.
DOI : 10.1001/archderm.131.8.904