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Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice.

Abstract : Recent advances in the understanding of the neurobiological basis of alcohol dependence suggest that the endocannabinoid system may play a key role in the reinforcing effects of ethanol. In the present study, disruption of CB1 receptors in mice generated on a CD1 background decreased both ethanol consumption and preference. This decreased ethanol self-administration was associated with increased sensitivity to the acute intoxicating effects of ethanol. Mutant mice were more sensitive to the hypothermic and sedative/hypnotic effects of acute ethanol administration (1.5-4.0 g/kg), although plasma ethanol concentrations did not differ from those of controls. Moreover, wild-type mice exhibited normal locomotor activation caused by 1.0-2.5 g/kg injection of ethanol, whereas mutant mice displayed sedation in response to the injection of the same ethanol doses. The severity of alcohol withdrawal-induced convulsions was also increased in CB1(-/-) mice. Our results suggest that CB1 receptors participate in the regulation of ethanol drinking and demonstrate that their disruption lead to increased ethanol sensitivity and withdrawal severity.
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https://www.hal.inserm.fr/inserm-00746177
Contributor : Mickael Naassila <>
Submitted on : Saturday, October 27, 2012 - 7:45:34 PM
Last modification on : Saturday, August 15, 2020 - 8:26:03 PM

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  • HAL Id : inserm-00746177, version 1
  • PUBMED : 14680762

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Mickaël Naassila, Olivier Pierrefiche, Catherine Ledent, Martine Daoust. Decreased alcohol self-administration and increased alcohol sensitivity and withdrawal in CB1 receptor knockout mice.. Neuropharmacology, Elsevier, 2004, 46 (2), pp.243-53. ⟨inserm-00746177⟩

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