D. Hankins, C. Drage, N. Zamel, and R. Kronenberg, Pulmonary function in identical twins 644 raised apart, Am Rev Respir Dis, vol.125, issue.2, pp.119-140, 1982.

S. Guerra and H. Boezen, Asthma and chronic obstructive pulmonary disease, Current Opinion in Allergy and Clinical Immunology, vol.9, issue.5, pp.409-1696, 2004.
DOI : 10.1097/ACI.0b013e3283300baf

M. Moffatt, M. Kabesch, L. Liang, A. Dixon, D. Strachan et al., Genetic variants 654 regulating ORMDL3 expression contribute to the risk of childhood asthma, Nature, vol.655, issue.6, pp.470-473, 2007.

M. Moffatt, I. Gut, F. Demenais, D. Strachan, E. Bouzigon et al., A large- 660 scale, consortium-based genomewide association study of asthma, N Engl J Med, vol.661, issue.8, pp.1211-1232, 2010.

P. Sleiman, F. J. Imielinski, M. Bradfield, J. Annaiah, K. Willis-owen et al., Associated with Asthma in Children, New England Journal of Medicine, vol.362, issue.1, pp.36-664, 2010.
DOI : 10.1056/NEJMoa0901867

A. Dewan, E. Triche, X. Xu, L. Hsu, C. Zhao et al., PDE11A associations 666 with asthma: results of a genome-wide association scan, J Allergy Clin Immunol, vol.667, issue.668, pp.871-874, 2010.

D. Hancock, I. Romieu, M. Shi, J. Sienra-monge, H. Wu et al., Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children, PLoS Genetics, vol.31, issue.8, pp.1000623-671, 2009.
DOI : 10.1371/journal.pgen.1000623.s003

S. Pillai, D. Ge, G. Zhu, X. Kong, K. Shianna et al., A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci, PLoS Genetics, vol.18, issue.3, pp.1000421-674, 2009.
DOI : 10.1371/journal.pgen.1000421.s007

S. Pillai, X. Kong, L. Edwards, M. Cho, W. Anderson et al., Loci 675 Identified by Genome-wide Association Studies Influence Different Disease-related 676 Phenotypes in COPD, Am J Respir Crit Care Med, vol.677, p.13, 2010.

M. Cho, N. Boutaoui, B. Klanderman, J. Sylvia, J. Ziniti et al., Variants in 678 FAM13A are associated with chronic obstructive pulmonary disease, Nat Genet, vol.679, issue.680, pp.200-202, 2010.

J. Wilk, T. Chen, D. Gottlieb, R. Walter, M. Nagle et al., A genome- 684 wide association study of pulmonary function measures in the Framingham Heart Study, p.685

D. Hancock, M. Eijgelsheim, J. Wilk, S. Gharib, L. Loehr et al., Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function, Nature Genetics, vol.21, issue.1, pp.45-52, 2010.
DOI : 10.1002/gepi.20303

E. Repapi, I. Sayers, L. Wain, P. Burton, T. Johnson et al., Genome-wide 690 association study identifies five loci associated with lung function, Nat Genet, vol.691, issue.692, pp.36-44, 2010.

M. Artigas, D. Loth, L. Wain, S. Gharib, M. Obeidat et al., Genome-wide 693 association and large-scale follow up identifies 16 new loci influencing lung function, p.694
DOI : 10.1038/ng.941

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376

S. Weiss, Lung function and airway diseases, Nature Genetics, vol.1, issue.1, pp.14-20, 2010.
DOI : 10.1038/nature06846

S. Weiss, What genes tell us about the pathogenesis of asthma and chronic obstructive 697 pulmonary disease, Am J Respir Crit Care Med, vol.181, p.699, 2010.

E. Silverman, L. Palmer, J. Mosley, M. Barth, J. Senter et al., Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early-Onset Chronic Obstructive Pulmonary Disease, The American Journal of Human Genetics, vol.70, issue.5, pp.1229-1268, 2002.
DOI : 10.1086/340316

J. Wilk, A. Destefano, D. Arnett, S. Rich, L. Djousse et al., A Genome-Wide Scan of Pulmonary Function Measures in the National Heart, Lung, and Blood Institute Family Heart Study, American Journal of Respiratory and Critical Care Medicine, vol.167, issue.11, pp.1528-1561, 2003.
DOI : 10.1164/rccm.200207-755OC

C. Holberg, W. Morgan, A. Wright, and F. Martinez, between Asthmatic and Nonasthmatic Families, American Journal of Respiratory and Critical Care Medicine, vol.158, issue.1, pp.162-171, 1998.
DOI : 10.1164/ajrccm.158.1.9706117

F. Kauffmann, M. Dizier, I. Pin, E. Paty, F. Gormand et al., Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy, American Journal of Respiratory and Critical Care Medicine, vol.156, issue.4, pp.123-92338, 1997.
DOI : 10.1164/ajrccm.156.4.12tac9

URL : https://hal.archives-ouvertes.fr/hal-00596474

A. Marossy, D. Strachan, A. Rudnicka, and H. Anderson, Childhood chest illness and the 725 rate of decline of adult lung function between ages 35 and 45 years, Am J Respir Crit, p.726

X. Li, T. Howard, W. Moore, E. Ampleford, H. Li et al., Importance of hedgehog interacting protein and other lung function genes in asthma, Journal of Allergy and Clinical Immunology, vol.127, issue.6, pp.1457-65, 2011.
DOI : 10.1016/j.jaci.2011.01.056

A. Malhotra, A. Peiffer, D. Ryujin, T. Elsner, R. Kanner et al., Further Evidence for the Role of Genes on Chromosome 2 and Chromosome 5 in the Inheritance of Pulmonary Function, American Journal of Respiratory and Critical Care Medicine, vol.168, issue.5, pp.556-61, 2003.
DOI : 10.1164/rccm.200303-410OC

C. Ober, M. Abney, and M. Mcpeek, The Genetic Dissection of Complex Traits in a Founder Population, The American Journal of Human Genetics, vol.69, issue.5, pp.1068-79, 2001.
DOI : 10.1086/324025

E. Bouzigon, M. Dizier, C. Krahenbuhl, A. Lemainque, I. Annesi-maesano et al., Clustering patterns of LOD scores for asthma-related phenotypes revealed by a genome-wide screen in 295 French EGEA families, Human Molecular Genetics, vol.13, issue.24, pp.3103-3116, 2004.
DOI : 10.1093/hmg/ddh340

URL : https://hal.archives-ouvertes.fr/hal-00595818

S. Barton, G. Koppelman, J. Vonk, C. Browning, I. Nolte et al., PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline, Journal of Allergy and Clinical Immunology, vol.123, issue.6, pp.1391-400, 2009.
DOI : 10.1016/j.jaci.2009.03.014

X. Xu, Z. Fang, B. Wang, C. Chen, W. Guang et al., A Genomewide Search for Quantitative-Trait Loci Underlying Asthma, The American Journal of Human Genetics, vol.69, issue.6, pp.1271-1278, 2001.
DOI : 10.1086/324650

F. Gilliland, W. Gauderman, H. Vora, E. Rappaport, and L. Dubeau, Effects of Glutathione-S-Transferase M1, T1, and P1 on Childhood Lung Function Growth, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.5, pp.710-716, 2002.
DOI : 10.1164/rccm.2112065

M. Glutathione-s-transferase, P1 and T1 polymorphisms and severity of lung 752 disease in children with cystic fibrosis, Pharmacogenetics, vol.14, issue.753, pp.295-301, 2004.

E. Del-rio-navarro and B. , Genetic polymorphism of GSTM1 and antioxidant 755 supplementation influence lung function in relation to ozone exposure in asthmatic 756 children in Mexico City, Thorax, vol.59, issue.757, pp.8-10, 2004.

M. Imboden, S. Downs, O. Senn, G. Matyas, O. Brandli et al., Glutathione S- 758 transferase genotypes modify lung function decline in the general population: 759 SAPALDIA cohort study, Respir Res, vol.8, issue.760, p.43, 2007.

H. Jongepier, H. Boezen, A. Dijkstra, T. Howard, J. Vonk et al., 761 Polymorphisms of the ADAM33 gene are associated with accelerated lung function 762 decline in asthma 764 Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired 765 early-life lung function, Clin Exp Allergy Am J Respir Crit Care Med, vol.34, issue.172, pp.757-6055, 2004.

C. Van-diemen, D. Postma, J. Vonk, M. Bruinenberg, J. Schouten et al., Adam33 polymorphisms are associated with COPD and lung function in long-term 768 tobacco smokers A 770 disintegrin and metalloprotease 33 polymorphisms and lung function decline in the 771 general population, Respir Res Am J Respir Crit Care Med, vol.10, issue.772, pp.21-769, 2005.

A. Dijkstra, J. Vonk, H. Jongepier, G. Koppelman, J. Schouten et al., Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex, Thorax, vol.61, issue.2, pp.105-115, 2006.
DOI : 10.1136/thx.2004.039271

N. Caporaso, F. Gu, N. Chatterjee, J. Sheng-chih, K. Yu et al., Genome-wide 780 and candidate gene association study of cigarette smoking behaviors, PLoS One, vol.781, issue.782, pp.4653-50, 2009.

U. Sovio, A. Bennett, I. Millwood, J. Molitor, O. Reilly et al., Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966, PLoS Genetics, vol.44, issue.3, pp.1000409-788, 2009.
DOI : 10.1371/journal.pgen.1000409.s003

S. Kang, C. Chiang, C. Palmer, B. Tayo, G. Lettre et al., Genome-wide 789 association of anthropometric traits in African-and African-derived populations, p.790

A. Palamarchuk, A. Efanov, N. Nazaryan, U. Santanam, H. Alder et al., 13q14 deletions in CLL involve cooperating tumor suppressors, Blood, vol.115, issue.19, pp.3916-3938
DOI : 10.1182/blood-2009-10-249367

M. Hammarsund, M. Corcoran, W. Wilson, C. Zhu, S. Einhorn et al., - located in the 13q14 tumor suppressor locus, FEBS Letters, vol.82, issue.1-3, pp.75-80, 2004.
DOI : 10.1016/S0014-5793(03)01371-1

Y. Pekarsky, N. Zanesi, and C. Croce, Molecular basis of CLL, Seminars in Cancer Biology, vol.20, issue.6, p.57, 2010.
DOI : 10.1016/j.semcancer.2010.09.003

S. Cooke, J. Pole, S. Chin, I. Ellis, C. Caldas et al., High-resolution array CGH clarifies events occurring on 8p in carcinogenesis, BMC Cancer, vol.21, issue.1, pp.288-58, 2008.
DOI : 10.1093/bioinformatics/bti500

X. Wang, D. Dockery, D. Wypij, M. Fay, B. Ferris et al., Pulmonary function between 6 and 18 years of age, Pediatric Pulmonology, vol.123, issue.2, pp.75-88, 1993.
DOI : 10.1002/ppul.1950150204

N. Kunzli, U. Ackermann-liebrich, R. Keller, A. Perruchoud, and C. Schindler, Variability of FVC and FEV<SUB>1</SUB> due to technician, team, device and subject in an eight centre study: three quality control studies in SAPALDIA, European Respiratory Journal, vol.8, issue.3, pp.371-377, 1995.
DOI : 10.1183/09031936.95.08030371

D. Vercelli and F. Martinez, The Faustian bargain of genetic association studies: Bigger might not be better, or at least it might not be good enough, Journal of Allergy and Clinical Immunology, vol.117, issue.6, pp.1303-1308, 2006.
DOI : 10.1016/j.jaci.2006.03.030

P. Quanjer, G. Tammeling, J. Cotes, O. Pedersen, R. Peslin et al., Lung 812 volumes and forced ventilatory flows, Report Working Party Standardization of Lung, vol.813
DOI : 10.1183/09041950.005s1693