P. Burney and R. Hooper, Forced vital capacity, airway obstruction and survival in a general population sample from the USA, Thorax, vol.66, issue.1, pp.49-54, 2011.
DOI : 10.1136/thx.2010.147041

K. Stavem, E. Aaser, L. Sandvik, J. Bjørnholt, and G. Erikssen, Lung function, smoking and mortality in a 26-year follow-up of healthy middle-aged males, European Respiratory Journal, vol.25, issue.4, pp.618-625, 2005.
DOI : 10.1183/09031936.05.00008504

H. Schünemann, J. Dorn, B. Grant, W. Winkelstein, and M. Trevisan, Pulmonary Function Is a Long-term Predictor of Mortality in the General Population, Chest, vol.118, issue.3, pp.656-664, 2000.
DOI : 10.1378/chest.118.3.656

P. Lange, J. Nyboe, M. Appleyard, G. Jensen, and P. Schnohr, Spirometric findings and mortality in never-smokers, Journal of Clinical Epidemiology, vol.43, issue.9, pp.867-873, 1990.
DOI : 10.1016/0895-4356(90)90070-6

M. Eisner, Y. Wang, T. Haight, J. Balmes, and S. Hammond, Secondhand Smoke Exposure, Pulmonary Function, and Cardiovascular Mortality, Annals of Epidemiology, vol.17, issue.5, pp.364-373, 2007.
DOI : 10.1016/j.annepidem.2006.10.008

P. Carta, G. Aru, M. Barbieri, G. Avataneo, and D. Casula, Dust exposure, respiratory symptoms, and longitudinal decline of lung function in young coal miners., Occupational and Environmental Medicine, vol.53, issue.5, pp.312-319, 1996.
DOI : 10.1136/oem.53.5.312

F. Kauffmann, D. Drouet, J. Lellouch, and D. Brille, Occupational exposure and 12-year spirometric changes among Paris area workers., Occupational and Environmental Medicine, vol.39, issue.3, pp.221-232, 1982.
DOI : 10.1136/oem.39.3.221

J. Sunyer, J. Zock, H. Kromhout, R. Garcia-esteban, and K. Radon, Lung Function Decline, Chronic Bronchitis, and Occupational Exposures in Young Adults, American Journal of Respiratory and Critical Care Medicine, vol.172, issue.9, pp.1139-1145, 2005.
DOI : 10.1164/rccm.200504-648OC

S. Downs, C. Schindler, L. Liu, D. Keidel, and L. Bayer-oglesby, and Attenuated Age-Related Decline in Lung Function, New England Journal of Medicine, vol.357, issue.23, pp.2338-2347, 2007.
DOI : 10.1056/NEJMoa073625

I. Rahman and I. Adcock, Oxidative stress and redox regulation of lung inflammation in COPD, European Respiratory Journal, vol.28, issue.1, pp.219-242, 2006.
DOI : 10.1183/09031936.06.00053805

W. Macnee, Pulmonary and Systemic Oxidant/Antioxidant Imbalance in Chronic Obstructive Pulmonary Disease, Proceedings of the American Thoracic Society, vol.2, issue.1, pp.50-60, 2005.
DOI : 10.1513/pats.200411-056SF

I. Hall and D. Lomas, The genetics of obstructive lung disease: big is beautiful, Thorax, vol.65, issue.9, pp.760-761, 2010.
DOI : 10.1136/thx.2010.147173

E. Silverman, A. Spira, and P. Pare, Genetics and Genomics of Chronic Obstructive Pulmonary Disease, Proceedings of the American Thoracic Society, vol.6, issue.6, pp.539-542, 2009.
DOI : 10.1513/pats.200904-021DS

J. Smolonska, C. Wijmenga, D. Postma, and H. Boezen, Meta-analyses on Suspected Chronic Obstructive Pulmonary Disease Genes, American Journal of Respiratory and Critical Care Medicine, vol.180, issue.7, pp.618-631, 2009.
DOI : 10.1164/rccm.200905-0722OC

J. He, J. Connett, N. Anthonisen, P. Pare, and A. Sandford, Glutathione S-Transferase Variants and Their Interaction with Smoking on Lung Function, American Journal of Respiratory and Critical Care Medicine, vol.170, issue.4, pp.388-394, 2004.
DOI : 10.1164/rccm.200312-1763OC

D. Hancock, M. Eijgelsheim, J. Wilk, S. Gharib, and L. Loehr, Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function, Nature Genetics, vol.21, issue.1, pp.45-52, 2010.
DOI : 10.1002/gepi.20303

E. Repapi, I. Sayers, L. Wain, P. Burton, and T. Johnson, Genome-wide association study identifies five loci associated with lung function, Nature Genetics, vol.79, issue.1, pp.36-44, 2010.
DOI : 10.1007/s10875-006-9029-z

S. Pillai, D. Ge, G. Zhu, X. Kong, and K. Shianna, A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci, PLoS Genetics, vol.18, issue.3, p.1000421, 2009.
DOI : 10.1371/journal.pgen.1000421.s007

M. Cho, N. Boutaoui, B. Klanderman, J. Sylvia, and J. Ziniti, Variants in FAM13A are associated with chronic obstructive pulmonary disease, Nature Genetics, vol.452, issue.3, pp.200-202, 2010.
DOI : 10.1038/ng.535

J. Wilk, T. Chen, D. Gottlieb, R. Walter, and M. Nagle, A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study, PLoS Genetics, vol.16, issue.3, p.1000429, 2009.
DOI : 10.1371/journal.pgen.1000429.s001

M. Artigas, D. Loth, L. Wain, S. Gharib, and M. Obeidat, Genomewide association and large-scale follow up identifies 16 new loci influencing lung function, Nature Genetics, 2011.
DOI : 10.1038/ng.941

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267376

. Obeidat-me, L. Wain, N. Shrine, N. Kalsheker, and M. Artigas, A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample, PLoS ONE, vol.17, issue.5, p.19382, 2011.
DOI : 10.1371/journal.pone.0019382.s005

S. Pillai, X. Kong, L. Edwards, M. Cho, and W. Anderson, Loci Identified by Genome-wide Association Studies Influence Different Disease-related Phenotypes in Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine, vol.182, issue.12, pp.1498-1505, 2010.
DOI : 10.1164/rccm.201002-0151OC

M. Ege, D. Strachan, W. Cookson, M. Moffatt, and I. Gut, Gene-environment interaction for childhood asthma and exposure to farming in Central Europe, Journal of Allergy and Clinical Immunology, vol.127, issue.1, pp.138-144, 2011.
DOI : 10.1016/j.jaci.2010.09.041

D. Thomas, Methods for Investigating Gene-Environment Interactions in Candidate Pathway and Genome-Wide Association Studies, Annual Review of Public Health, vol.31, issue.1, pp.21-36, 2010.
DOI : 10.1146/annurev.publhealth.012809.103619

L. Marchand, L. Wilkens, and L. , Design Considerations for Genomic Association Studies: Importance of Gene-Environment Interactions, Cancer Epidemiology Biomarkers & Prevention, vol.17, issue.2, pp.263-267, 2008.
DOI : 10.1158/1055-9965.EPI-07-0402

I. Yang, K. Fong, P. Zimmerman, S. Holgate, and J. Holloway, Genetic susceptibility to the respiratory effects of air pollution, Postgraduate Medical Journal, vol.85, issue.1006, pp.555-563, 2008.
DOI : 10.1136/thx.2007.079426

I. Curjuric, M. Imboden, C. Schindler, S. Downs, and M. Hersberger, HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction, European Respiratory Journal, vol.35, issue.3, pp.505-514, 2010.
DOI : 10.1183/09031936.000443-2009

M. Siedlinski, D. Postma, C. Van-diemen, A. Blokstra, and H. Smit, Lung Function Loss, Smoking, Vitamin C Intake, and Polymorphisms of the Glutamate-Cysteine Ligase Genes, American Journal of Respiratory and Critical Care Medicine, vol.178, issue.1, pp.13-19, 2008.
DOI : 10.1164/rccm.200711-1749OC

E. Bouzigon, E. Corda, H. Aschard, M. Dizier, and A. Boland, Effect of 17q21 Variants and Smoking Exposure in Early-Onset Asthma, New England Journal of Medicine, vol.359, issue.19, pp.1985-1994, 2008.
DOI : 10.1056/NEJMoa0806604

URL : https://hal.archives-ouvertes.fr/inserm-00335307

Y. Van-durme, M. Eijgelsheim, G. Joos, A. Hofman, and A. Uitterlinden, Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study, European Respiratory Journal, vol.36, issue.1, pp.89-95, 2010.
DOI : 10.1183/09031936.00129509

B. Fridley and J. Biernacka, Gene set analysis of SNP data: benefits, challenges, and future directions, European Journal of Human Genetics, vol.11, issue.8, pp.837-843, 2011.
DOI : 10.1093/nar/gkq324

U. Ackermann-liebrich, B. Kuna-dibbert, N. Probst-hensch, C. Schindler, F. Dietrich et al., Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991???2003: methods and characterization of participants, Sozial- und Pr??ventivmedizin SPM, vol.50, issue.4, pp.245-263, 2005.
DOI : 10.1007/s00038-005-4075-5

B. Martin, U. Ackermann-liebrich, P. Leuenberger, N. Kunzli, and E. Stutz, SAPALDIA: Methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults, Sozial- und Pr???ventivmedizin SPM, vol.7, issue.suppl 5, pp.67-84, 1997.
DOI : 10.1007/BF01318136

N. Kunzli, U. Ackermann-liebrich, R. Keller, A. Perruchoud, and C. Schindler, Variability of FVC and FEV<SUB>1</SUB> due to technician, team, device and subject in an eight centre study: three quality control studies in SAPALDIA, European Respiratory Journal, vol.8, issue.3, pp.371-376, 1995.
DOI : 10.1183/09031936.95.08030371

N. Kunzli, B. Kuna-dibbert, D. Keidel, R. Keller, and O. Brandli, Longitudinal validity of spirometers?a challenge in longitudinal studies, Swiss Medical Weekly, vol.135, pp.503-508, 2005.

L. Liu, I. Curjuric, D. Keidel, J. Heldstab, and N. Kunzli, Characterization of Source-Specific Air Pollution Exposure for a Large Population-Based Swiss Cohort (SAPALDIA), Environmental Health Perspectives, vol.115, issue.11, pp.1638-1645, 2007.
DOI : 10.1289/ehp.10177

M. Moffatt, I. Gut, F. Demenais, D. Strachan, and E. Bouzigon, A Large-Scale, Consortium-Based Genomewide Association Study of Asthma, New England Journal of Medicine, vol.363, issue.13, pp.1211-1221, 2010.
DOI : 10.1056/NEJMoa0906312

URL : https://hal.archives-ouvertes.fr/inserm-00748663

Y. Li, C. Willer, J. Ding, P. Scheet, and G. Abecasis, MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes, Genetic Epidemiology, vol.80, issue.8, pp.816-834, 2010.
DOI : 10.1002/gepi.20533

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175618

M. Ashburner, C. Ball, J. Blake, D. Botstein, and H. Butler, Gene Ontology: tool for the unification of biology, Nature Genetics, vol.9, issue.1, pp.25-29, 2000.
DOI : 10.1038/75556

N. Elliott and M. Volkert, Stress Induction and Mitochondrial Localization of Oxr1 Proteins in Yeast and Humans, Molecular and Cellular Biology, vol.24, issue.8, pp.3180-3187, 2004.
DOI : 10.1128/MCB.24.8.3180-3187.2004

M. Kaimul-ahsan, H. Nakamura, M. Tanito, K. Yamada, and H. Utsumi, Thioredoxin-1 suppresses lung injury and apoptosis induced by diesel exhaust particles (DEP) by scavenging reactive oxygen species and by inhibiting DEP-induced downregulation of Akt, Free Radical Biology and Medicine, vol.39, issue.12, pp.1549-1559, 2005.
DOI : 10.1016/j.freeradbiomed.2005.07.016

C. Nickel, M. Trujillo, S. Rahlfs, M. Deponte, and R. Radi, Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite, Biological Chemistry, vol.386, issue.11, pp.1129-1136, 2005.
DOI : 10.1515/BC.2005.129

M. Tomita, T. Okuyama, H. Katsuyama, K. Hidaka, and T. Otsuki, Gene expression in rat lungs during early response to paraquat-induced oxidative stress, International Journal of Molecular Medicine, vol.17, pp.37-44, 2006.
DOI : 10.3892/ijmm.17.1.37

C. Tseng, H. Huang, Y. Yang, and S. Mao, Purification of human haptoglobin 1-1, 2-1, and 2-2 using monoclonal antibody affinity chromatography, Protein Expression and Purification, vol.33, issue.2, pp.265-273, 2004.
DOI : 10.1016/j.pep.2003.09.006

D. Karolchik, A. Hinrichs, T. Furey, K. Roskin, and C. Sugnet, The UCSC Table Browser data retrieval tool, Nucleic Acids Research, vol.32, issue.90001, pp.493-496, 2004.
DOI : 10.1093/nar/gkh103

Y. Aulchenko, M. Struchalin, and C. Van-duijn, ProbABEL package for genome-wide association analysis of imputed data, BMC Bioinformatics, vol.11, issue.1, pp.134-134, 2010.
DOI : 10.1186/1471-2105-11-134

K. Yu, Q. Li, A. Bergen, R. Pfeiffer, and P. Rosenberg, -values, Genetic Epidemiology, vol.61, issue.8, pp.700-709, 2009.
DOI : 10.1002/gepi.20422

URL : https://hal.archives-ouvertes.fr/hal-01258459

W. Gauderman and J. Morrison, QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies Available: http://hydra, 2006.

J. Araujo and A. Nel, Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress, Particle and Fibre Toxicology, vol.6, issue.1, p.24, 2009.
DOI : 10.1186/1743-8977-6-24

N. Li, M. Hao, R. Phalen, W. Hinds, and A. Nel, Particulate air pollutants and asthma, Clinical Immunology, vol.109, issue.3, pp.250-265, 2003.
DOI : 10.1016/j.clim.2003.08.006

N. Li, S. Kim, M. Wang, J. Froines, and C. Sioutas, USE OF A STRATIFIED OXIDATIVE STRESS MODEL TO STUDY THE BIOLOGICAL EFFECTS OF AMBIENT CONCENTRATED AND DIESEL EXHAUST PARTICULATE MATTER, Inhalation Toxicology, vol.14, issue.5, pp.459-486, 2002.
DOI : 10.1080/089583701753678571

A. Comandini, V. Marzano, G. Curradi, G. Federici, and A. Urbani, Markers of anti-oxidant response in tobacco smoke exposed subjects: A data-mining review, Pulmonary Pharmacology & Therapeutics, vol.23, issue.6, pp.482-92, 2010.
DOI : 10.1016/j.pupt.2010.05.006

S. Faux, T. Tai, D. Thorne, Y. Xu, and D. Breheny, The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke, Biomarkers, vol.673, issue.1, pp.90-96, 2009.
DOI : 10.1016/0891-5849(94)00236-D

K. Aoshiba, J. Tamaoki, and A. Nagai, Acute cigarette smoke exposure induces apoptosis of alveolar macrophages, American Journal of Physiology -Lung Cellular and Molecular Physiology, vol.281, pp.1392-1401, 2001.

H. Kim, X. Wang, Z. Chen, S. Lee, and M. Huang, Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1, Autophagy, vol.4, issue.7, pp.887-895, 2008.
DOI : 10.4161/auto.6767

D. Slebos, S. Ryter, M. Van-der-toorn, F. Liu, and F. Guo, Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke???Induced Cell Death, American Journal of Respiratory Cell and Molecular Biology, vol.36, issue.4, pp.409-417, 2007.
DOI : 10.1165/rcmb.2006-0214OC

H. Van-der-vaart, D. Postma, W. Timens, and N. Ten-hacken, Acute effects of cigarette smoke on inflammation and oxidative stress: a review, Thorax, vol.59, issue.8, pp.713-721, 2004.
DOI : 10.1136/thx.2003.012468

P. Kraft, Curses???Winner??s and Otherwise???in Genetic Epidemiology, Epidemiology, vol.19, issue.5, pp.649-651, 2008.
DOI : 10.1097/EDE.0b013e318181b865

J. Sacks, L. Stanek, T. Luben, D. Johns, and B. Buckley, Particulate Matter???Induced Health Effects: Who Is Susceptible?, Environmental Health Perspectives, vol.119, issue.4, pp.446-454, 2011.
DOI : 10.1289/ehp.1002255