Skip to Main content Skip to Navigation
Journal articles

Exosomes as intercellular signalosomes and pharmacological effectors.

Abstract : Cell secretion is a general process involved in various biological responses. Exosomes are part of this process and have gained considerable scientific interest in the past five years. Several steps through investigations across the last 20 years can explain this interest. First characterized during reticulocyte maturation, they were next evidenced as a key player in the immune response and cancer immunotherapy. More recently they were reported as vectors of mRNAs, miRNAs and also lipid mediators able to act on target cells. They are the only type of vesicles released from an intracellular compartment from cells in viable conditions. They appear as a vectorized signaling system operating from inside a donor cell towards either the periphery, the cytosol, or possibly to the nucleus of target cells. Exosomes from normal cells trigger positive effects, whereas those from pathological ones, such as tumor cells or infected ones may trigger non-positive health effects. Therefore regulating the biogenesis and secretion of exosomes appear as a pharmacological challenge to intervene in various pathophysiologies. Exosome biogenesis and molecular content, interaction with target cells, utilisation as biomarkers, and functional effects in various pathophysiologies are considered in this review.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00743451
Contributor : Marc Poirot <>
Submitted on : Friday, October 19, 2012 - 8:59:29 AM
Last modification on : Tuesday, June 30, 2020 - 3:10:55 AM

Links full text

Identifiers

Collections

Citation

Michel Record, Caroline Subra, Sandrine Silvente-Poirot, Marc Poirot. Exosomes as intercellular signalosomes and pharmacological effectors.. Biochemical Pharmacology, Elsevier, 2011, 81 (10), pp.1171-82. ⟨10.1016/j.bcp.2011.02.011⟩. ⟨inserm-00743451⟩

Share

Metrics

Record views

296